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http://nopr.niscpr.res.in/handle/123456789/8761| Title: | ZrCl4 catalyzed efficient one-pot synthesis of novel methylene-bis-β-amino/methylene-bis-β-acetamido ketones |
| Authors: | Reddy, Ch Sanjeeva Nagaraj, A Srinivas, A Reddy, G Purnachandra |
| Keywords: | Mannich-type reaction;one-pot synthesis;zirconium(IV)chloride |
| Issue Date: | May-2010 |
| Publisher: | CSIR |
| Abstract: | Zirconium(IV)chloride (ZrCl4) catalyzed efficient one-pot synthesis of methylene-bis-β-amino/methylene-bis-β-acetamido ketones at room temperature has been described. In the presence of ZrCl4, the three-component Mannich-type reaction via a variety of in situ generated aldimines with various ketones, methylene-bis-methoxybenzaldehyde and aromatic amines in ethanol, led to the formation of methylene-bis-β-amino ketones and the four-component Mannich-type reaction of methylene-bis-methoxybenzaldehyde with ketones, acetonitrile and acetyl chloride resulted in the corresponding methylene-bis-β-acetamido ketones in high to excellent yields. All the newly synthesized compounds have been characterized by their spectral and elemental analyses |
| Page(s): | 617-622 |
| Appears in Collections: | IJC-B Vol.49B(05) [May 2010] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 49B(5) 617-622.pdf | 172.62 kB | Adobe PDF | View/Open |
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