http://nopr.niscpr.res.in/handle/123456789/12483 2026-10-10T21:41:55Z 2026-10-10T21:41:55Z Bayat, Parvin Dokht Ghanbari, Ali Babaei, Saeid Khazaei, Mozafar Ghorbani, Rostam Ayubian, Mahmood http://nopr.niscpr.res.in/handle/123456789/12529 2011-08-03T16:30:55Z 2011-08-01T00:00:00Z

Title: Effect of exposure to extremely low electro-magnetic field during prenatal period on mice spleen Authors: Bayat, Parvin Dokht; Ghanbari, Ali; Babaei, Saeid; Khazaei, Mozafar; Ghorbani, Rostam; Ayubian, Mahmood Abstract: Total body weight of newborns, the volume of spleen, and the number of megakaryocytes decreased following the exposure to ELF-MF (6x10^-3 T and 50 Hz) at 1-5, 6-10, 11-15, and 16-20 days of pregnancy of mice. The complete period of gestation was sensitive to ELF-MF exposure; the initial days were more prone to exposure. The results suggest that the use of ELF-MF producing instruments should be limited during gestation. Page(s): 634-638

2011-08-01T00:00:00Z Pujari, Rohini R Vyawahare, Neeraj S Kagathara, Virendra G http://nopr.niscpr.res.in/handle/123456789/12528 2011-08-05T16:30:49Z 2011-08-01T00:00:00Z

Title: Evaluation of antioxidant and neuroprotective effect of date palm (<i style="">Phoenix dactylifera </i>L.) against bilateral common carotid artery occlusion in rats Authors: Pujari, Rohini R; Vyawahare, Neeraj S; Kagathara, Virendra G Abstract: The cerebral ischemia in rats was induced by occluding bilateral common carotid arteries (BCCAO) for 30 min., followed by 45 min reperfusion. BCCAO caused significant depletion in superoxide dismutase, catalase, glutathione, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and significant increase in lipid peroxidation along with severe neuronal damage in the brain. All the alterations except depletion in glutathione peroxidase and glutathione-S-transferase levels induced by cerebral ischemia were significantly attenuated by 15 days pretreatment with methanolic extract of <i style="">P. dactylifera</i> fruits (100, 300 mg/kg), whereas 30 mg/kg dose was insignificant in this regard. These results suggest the possible use <i style="">P. dactylifera</i> against bilateral common carotid artery occlusion induced oxidative stress and neuronal damage Page(s): 627-633

2011-08-01T00:00:00Z Gupta, Deepali Devadoss, Thangaraj Bhatt, Shvetank Gautam, Baldev Jindal, Ankur Pandey, Dilip Mahesh, Radhakrishnan http://nopr.niscpr.res.in/handle/123456789/12527 2011-08-02T16:31:10Z 2011-08-01T00:00:00Z

Title: Anti-depressant-like activity of a novel serotonin type-3 (5-HT₃) receptor antagonist in rodent models of depression Authors: Gupta, Deepali; Devadoss, Thangaraj; Bhatt, Shvetank; Gautam, Baldev; Jindal, Ankur; Pandey, Dilip; Mahesh, Radhakrishnan Abstract: <i style="">N</i>-Cyclohexyl-3-methoxyquinoxalin-2-carboxamide (QCM-13), a novel 5-HT₃antagonist identified from a series of compounds with higher pA₂ (7.6) and good log P (2.91) value was screened in rodent models of depression such as forced swim test (FST), tail suspension test (TST), interaction studies with standard anti-depressants and confirmatory studies such as reversal of parthenolide induced depression and reserpine induced hypothermia. In FST (2 and 4 mg/kg) and TST (2 and 4 mg/kg), QCM-13 significantly reduced the duration of immobility in mice without affecting the base line locomotion. QCM-13 (2 and 4 mg/kg) was also found to have significant interaction with standard anti-depressants (fluoxetine and bupropion in FST and TST respectively). Further, reversal of parthenolide induced depression in mice and reserpine induced hypothermia in rat models indicate the serotonergic influence of QCM-13 for anti-depressant potential. Page(s): 619-626

2011-08-01T00:00:00Z Gaur, Vaibhav Aggarwal, Aditi Kumar, Anil http://nopr.niscpr.res.in/handle/123456789/12526 2011-08-02T16:31:09Z 2011-08-01T00:00:00Z

Title: Possible nitric oxide mechanism in the protective effect of hesperidin against ischemic reperfusion cerebral injury in rats Authors: Gaur, Vaibhav; Aggarwal, Aditi; Kumar, Anil Abstract: Stroke is the third leading cause of death and disability around the globe. The aim of the present investigation was to evaluate the protective effect of hesperidin and its nitric oxide mechanism against cerebral ischemia reperfusion injury. Bilateral common carotid artery occlusion for 30 min followed by 24 h reperfusion was given to induce ischemia in rats. Animals were pretreated with hesperidin (50 and 100 mg/kg, po) for 7 days. Various behavioural tests, oxidative stress parameters, endogenous antioxidant system, antioxidant enzyme activity and mitochondrial enzyme complex (I, II, III and IV) dysfunctions in cortex and striatum were assessed subsequently. Hesperidin (50 and 100 mg/kg) significantly improved neurobehavioral alterations (neurological score, locomotor activity, resistance to lateral push and hanging wire latency), attenuated oxidative damage, restored antioxidant and mitochondrial complex enzyme activities in cortex and in striatum regions of the brain as compared to their respective controls. L-arginine (100 mg/kg) or L-NAME (10 mg/kg) pretreatment with lower dose of hesperidin (50 mg/kg) significantly reversed or potentiated its protective effect, respectively which was significant as compared to hesperidin (50 mg/kg). The results highlight the involvement of nitric oxide mechanism in the protective effect of hesperidin against ischemia reperfusion injury induced alterations. Page(s): 609-618

2011-08-01T00:00:00Z