NOPR Collection:

Elucidation of mechanism of Anti-arthritic action of Arthosansar- a polyherbal formulation

2016-07-20T04:50:16Z

Title: Elucidation of mechanism of Anti-arthritic action of Arthosansar- a polyherbal formulation Authors: Sumanth, Meera; Anusha; Swetha, S Abstract: To elucidate the mechanism of anti-arthritic action of the Arthosansar, a polyherbal formulation has proven anti-arthritic activity. The mechanism is elucidated by emphasizing on immunomodulation, anti-inflammatory and analgesic action. The study is carried out using CFA induced arthritis in rats, carrageenan induced peritonitis in mice, inflammation induced by various phlogistic agents in rats, acetic acid induced writhing in mice and tail-immersion test in mice. Arthosansar significantly (P<0.001) inhibited proliferation of lymphocytes in CFA induced arthritic rats. Arthosansar significantly (P<0.001) inhibited neutrophil infiltration in carrageenan induced peritonitis in mice, inhibited the release of inflammatory mediators (PGs, histamine, 5-HT and bradykinin) and pain mediated through these mediators in acetic acid induced writhing test. Arthosansar also showed significant (P<0.001) increase in latency period in tail immersion test in mice. Arthosansar exhibits anti-arthritic activity by. (a) Inhibiting lymphocyte proliferation (b) Inhibiting production of IF-, TNF-, IL-2 (c) Inhibiting release of inflammatory mediators PGs, histamine, 5-HT and bradykinin (d) Exhibits antinociceptive action through opioid receptors and by promoting release of endogenous peptides. Page(s): 704-713

Scientific evaluation of Panchkola curna – An Ayurvedic polyherbal drug formulation

2016-07-20T04:55:12Z

Title: Scientific evaluation of Panchkola curna – An Ayurvedic polyherbal drug formulation Authors: Rajput, S; Tripathi, MK; Tiwari, AK; Dwivedi, N; Tripathi, SP Abstract: The present study deals with the Scientific evaluation and Standardization of the Ayurvedic compound formulation Panchkola curna following quality control procedures both for the raw materials and the finished product. The obtained values (ranges of physico-chemical parameters) can be adapted to day down new pharmacopoeial standards to be followed for traditional preparation of Panchkola curna with batch to batch consistency. The phytochemical constituents found to present in the raw material used for the preparation of Panchkola curna facilitate the desirable therapeutic efficacy of the medicinal formulations a whole in elements and also could help in knowing the underlying mechanism of pharmacological action. Page(s): 697-703

Pharmacognosy of aconite sold under the name Vatsanabha in Indian market

2016-07-20T04:50:14Z

Title: Pharmacognosy of aconite sold under the name Vatsanabha in Indian market Authors: Sarkar, P K; Prajapati, P K; Pillai, A P G; Chauhan, M G Abstract: Aconite is one of the lethal poisons used in therapeutics of Ayurveda. It is sold under the name of Vatsanabha in Indian market. The aconite is generally found as mixture of different species of Aconitum, due to the close morphological similarity of the different species of aconites. The aims of the study were to identify different species of Aconitum present in the market samples of Vatsanabha and to find out the authentic species of Vatsanabha, i.e. Aconitum chasmanthum Stapf. ex Holmes in the market sample. Vatsanabha was sold from Indian markets and was identified by means of macroscopic and microscopic studies and by TLC profile. It was found that ‘Vatsanabha’ of Indian market is mixture of 8 species of Aconitum, 6 of these were identified as A. spicatum Stapf., A. falconeri Stapf., A. chasmanthum Stapf. ex Holmes, A. laciniatum Stapf., A. balfourii Holmes ex Stapf. and A. deinorrhizum Holmes ex Stapf. A. chasmanthum Stapf. ex Holmes species is rarely available in market samples. Page(s): 685-696

Evaluation of Ayurvedic compound formulations 4- Musli Cũrna

2016-07-20T04:54:11Z

Title: Evaluation of Ayurvedic compound formulations 4- Musli Cũrna Authors: Rastogi, Subha; Pandey, Madan Mohan; Khatoon, Sayyada; Mehrotra, Shanta; Rawat, Ajay Kumar Singh Abstract: Quality medications of any system of medicine are obtained only as a result of using standardized protocols and monitoring the quality of the products. Thus, there is an urgent need to develop reliable parameters for quality control which are cost effective and can be easily adopted by the manufacturers. In the Ayurvedic system of medicine, Musli Cũrna is a herbal compound formulation used as an aphrodisiac and for impotency. In the present communication, attempts have been made to evaluate Musli Cũrna. Four samples of Musli Cũrna procured from different Ayurvedic pharmacies were subjected to physicochemical analysis, HPTLC fingerprinting and botanical characterization, and compared using authentic ingredients as reference. The studies suggest that these parameters may, together, be used for quality evaluation and standardization of compound formulations and maintaining their quality, purity and efficacy. Page(s): 680-684