NOPR Collection:

A new pregnane derivative from the Indian ocean gorgonian Subergorgia suberosa (Pallas)

2013-10-08T16:34:57Z

Title: A new pregnane derivative from the Indian ocean gorgonian Subergorgia suberosa (Pallas) Authors: Subrahmanyam, C; Kumar, S Ratna; Reddy, G Damodar Abstract: 3, 3-Dimethoxy-5α-pregnan-20-one 1, a new compound, has been isolated from the gorgonian S. suberosa. Page(s): 219-220

Synthesis and bioevaluation of some novel nucleosides as antiherptic agents

2013-10-06T16:34:53Z

Title: Synthesis and bioevaluation of some novel nucleosides as antiherptic agents Authors: Chauhan, Deepa; Chauhan, J S; Singh, J; Bajpai, S K; Joshi, M N Abstract: N'-(5-Aryl-1 ,3,4-oxadiazolo-2-yl)-ureas on cyclocondensation with CS₂/KOH afford 2-aryl- 1,3,4-oxadiazole[3,2-a]-s-triazine-5,7-(6H) dithione nucleobase which on glycosylation with different sugars gives nucleoside analogues. Page(s): 215-218

One pot reaction: Synthesis, characterization and biological activity of 3-alkyl/aryl-9- substituted 1,2,4-triazolo[3,4-b] [1,3,4]quinolinothiadiazepines

2013-10-05T16:34:33Z

Title: One pot reaction: Synthesis, characterization and biological activity of 3-alkyl/aryl-9- substituted 1,2,4-triazolo[3,4-b] [1,3,4]quinolinothiadiazepines Authors: Kalluraya, Balakrishna; Gururaja, R.; Rai, Ganesha Abstract: Reaction of 6-substituted-2-chloro-3-formylquinoline 1 and 3-substituted-4-amino-5-mercapto-1,2,4-triazole 2 gave the novel thiadiazepine derivatives 5 rather than expected Schiff bases 4. Alternatively, compounds 5 were also prepared by the reaction of 2 with 6-substitutcri quinolones 3. The structures of the newly synthesized compounds have been proposed on the basis of elemental analysis, IR,¹H NMR and mass spectral data. Some of the new synthetic compounds were also screened for their antibacterial and antifungal activity. Most of them showed significant activity. Page(s): 211-214

Synthesis and biological activity of some new benzophenothiazines

2013-10-05T16:35:19Z

Title: Synthesis and biological activity of some new benzophenothiazines Authors: Pandey, V K; Negi, H S; Joshi, M N; Bajpai, Ms S K Abstract: Condensation of carboxylic acids with thiosemicarbazide in presence of conc. H₂SO₄ gives 2-amino-5-aralkyl-1,3,4-thiadiazoles 1 which on diazotization afford 5-aralkyl-1,3,4- thiadiazolyl-2-diazonium chlorides 2. Reaction of 2 with cold solution of β-naphthol in dilute NaOH furnishes α-(2-diazo-5-aralkyl-1,3,4-thiadiazolyl)-β-sodionaphthoxides 3 which on acidification with conc. HCl gives α-(2-diazo-5-aralkyl-1,3,4-thiadiazolyl)-β-naphthols 4. Reaction of 4 with p-anisidine gives α-(2-diazo-5-aralkyl-1,3, 4-thiadiazolyl)-β-(p-anisidino) naphthalenes 5. Fusion of 5 with sulphur in presence of iodine results in 1-(2'-diazo-5' -aralkyl-1',3',4' -thiadiazolyl)-6-methoxy benzophenothiazines 6 in yields varying from 48% to 59%. The new compounds 6 have been screened for their antiviral and antifungal activities. Page(s): 206-210