NOPR Collection:

Two pentacycIic triterpenes from the stem of Calotropis procera

2013-10-10T16:41:50Z

Title: Two pentacycIic triterpenes from the stem of Calotropis procera Authors: Gupta, Aditi; Singh, Rachana; Purwar, Chhavi; Chauhan, Deepa; Singh, J Abstract: Two saponins have been isolated from the stem of Calotropis procera and their structures established as 3-O-{α-L- rhamnopyranosyl(1→2)-β-D-xylopyranosyl(1→2)-β-D-glucopy ranosyl(1→6)-β-D-glcopyranosyl (1→3)-β-D-glucopyranoside}-3β-hydroxy olean- 12-ene-oic acid 1 and 3β-hydroxy olean-12-ene-28-oic acid-28-O-β-D-glucopyranoside 2 on the basis of chemical and spectral evidences. Page(s): 2030-2033

Screening of natural products for new leads as inhibitors of β-amyloid production : 2- Hydroxy-4-methoxy-3-prenyl-6-styrylbenzoic acid from Cajanus cajan

2013-10-09T16:42:25Z

Title: Screening of natural products for new leads as inhibitors of β-amyloid production : 2- Hydroxy-4-methoxy-3-prenyl-6-styrylbenzoic acid from Cajanus cajan Authors: Ramakrishna, N V S; Vijayakumar, E K S; Kulkarni, A S; Bhat, R G; Parikh, S; Deuskar, N; Kalakoti, B S Abstract: 2-Hydroxy-4-methoxy-3-prenyl-6-styrylbenzoic acid 1 has been isolated from the methylene chloride extract of the twigs of Cajanus cajan, and found to inhihit β- amyloid synthesis with an IC₅₀ of 70 μM. Page(s): 2028-2029

Chemoselective reaction of 1-p-acetanilido-3-acetyl-5-hydroxy-2-methylindole towards methyl chloroacetate :Synthesis and antiinflammatory activity of some new 5- pyrrolyl/oxadiazolyl/triazolyl/quinazolinylmethoxyindole derivatives

2013-10-08T16:40:20Z

Title: Chemoselective reaction of 1-p-acetanilido-3-acetyl-5-hydroxy-2-methylindole towards methyl chloroacetate :Synthesis and antiinflammatory activity of some new 5- pyrrolyl/oxadiazolyl/triazolyl/quinazolinylmethoxyindole derivatives Authors: Gadaginamath, G S; Pujar, S R; Kavali, R R Abstract: 1-p-Acetanilido-3-acetyl-5-hydroxy-2-methylindole when treated with CH₃I and K₂CO₃ in refluxing dry acetone produces N,O-methylated 1-p-N-methylacetanilido-3-acetyl-5-methoxy-2-methylindole but when it is reacted with methyl chloroacetate under similar reaction conditions yields only O-alkylated 1-p-acetanilido-3-acetyl-5-methoxycarbonylmethoxy-2-methylindole. This indole ester on treatment with hydrazine hydrate in refluxing ethanol gives only the monocarbohydrazide which is reacted separately with acetonyl acetone, triethyl orthoformate. CS₂, KOH/N₂H₄.H₂O, and 1,3-benzoxazine to secure pyrrolyl/oxadiazolyl/triazolyl and quinazolinylmethoxyindoles. Some of these new indole derivatives are screened for their antiinflammatoryactivity. Page(s): 2023-2027

Synthesis of pyrazoline and isoxazole derivatives bearing chloroquinoline nucleus as potential antimicrobial agents

2013-10-11T16:40:33Z

Title: Synthesis of pyrazoline and isoxazole derivatives bearing chloroquinoline nucleus as potential antimicrobial agents Authors: Dobaria, A V; Patel, J R; Parekh, H H Abstract: A series of pyrazolines 3a-j and isoxazoles 4a-k have been synthesized by the action of hydrazine hydrate and hydroxylamine hydrochloride respectively on 1-aryl-3-(2'-chloro-7'methylquinolin-3'-y l)-2-propen-1-ones 2 while the compounds 2 are prepared by the condensation of-2-chloro-7-methyl-quinoline-3-carboxaldehyde 1 with different aromatic ketones. All the compounds have been characterized on the basis of elemental analyses and spectral data. The compounds have been screened for their in vitro antifungal and antibacterial activities. Page(s): 2019-2022