NOPR Collection:

Overexpression of c-erbB-2 oncoprotein and associated pathobiological factors in invasive primary breast cancer

2013-11-19T16:48:52Z

Title: Overexpression of c-erbB-2 oncoprotein and associated pathobiological factors in invasive primary breast cancer Authors: Ray, Amitabha; Sharma, Bhuvnesh Kumar; Kaur, Sudershan; Sharma, Shashi; Sharma, Joginder Kumar Abstract: Breast cancer tissues from 271 cases were analyzed immunologically for c-erbB-2 oncoprotein (HER-2/neu), epidermal growth factor receptor (EGF-R) and estrogen receptor (ER). Overexpression of both c-erbB-2 oncoprotein and EGF-R showed an inverse association with ER and a direct association with metastatic involvement of lymph node and high histological grade. The frequency of c-erbB-2 and EGF-R overexpression was significantly higher among postmenopausal cases in comparison with premenopausal cases. Further, only in postmenopausal patients, c-erbB-2 oncoprotein (²=6.4, P < 0.05) and EGF-R (²=6.4, p<0.05) as well as their concomitant expression (²= 11.5, p<0.01) revealed a statistically significant association with ER. Page(s): 253-258

Nicotine induced alterations on reproductive organs of female rats under protein deficient condition

2013-11-12T16:47:58Z

Title: Nicotine induced alterations on reproductive organs of female rats under protein deficient condition Authors: Mandal, K; Dasgupta, S; Chattopadhyay, B D Abstract: Nicotine causes decrement in body weight, reduction in ovarian and uterine weight, irregularity in estrous cycle and histological damage in ovary and uterus in rats maintained on normal (18% casein) and protein restricted diet (5% casein). The degree of nicotine toxicity increases in protein inadequacy. Page(s): 330-332

Evaluation of phytochemical and antimicrobial properties of leaf extract of Tapinanthus sessilifolius (P. Beauv) van Tiegh

2013-11-13T16:48:39Z

Title: Evaluation of phytochemical and antimicrobial properties of leaf extract of Tapinanthus sessilifolius (P. Beauv) van Tiegh Authors: Tarfa, Florence D; Obodozie, Obiageri O; Mshelia, Emmanuel; Ibrahim, Kolo; Temple, V J Abstract: Leaf extracts of T. sessilifolius growing on five different host plants (Psidium guajava, Citrus lemon, Vernonia amygdalina, Persea americana and Jatropa curcas) were evaluated for antimicrobial activity of the plant. Powdered leaves of T. sessilifolius collected from each host plant was divided into two portions. One portion was used for aqueous infusion and the other portion was successively extracted with hexane, ethylacetate and methanol. Infusion of aqueous extract of powdered leaves did not show antimicrobial effect even at the concentration of 1000 and 2000μg/ml on test microorganisms (Staph. aureus, E. coli, Bacillus subtilis, Pseudomonas aeruginosa and Candida albicans). However in broth culture, methanolic and hexane extract had MIC range of 62.5-500μg/ml and ethyl acetate extract had 250-500μg/ml. Phytochemical screening of leaf samples of T.sessilifolius collected from different host plants showed positive test for hydrolysable tannins, saponins, flavonoids, terpenes, cardiac glycoside, reducing sugars and proteins.LD₅₀ concentration was found to be > 1.500 mg/kg for samples from P. guajava; 489.89 mg/kg for J. curcas and C. lemon; and 692 mg/kg for V. amydalina in mice. Page(s): 326-329

Disposition of uric acid upon administration of ofloxacin alone and in combination with other anti-tuberculosis drugs

2013-11-14T16:35:15Z

Title: Disposition of uric acid upon administration of ofloxacin alone and in combination with other anti-tuberculosis drugs Authors: Kurnar, A K Hernanth; Gurumurthy, Prema Abstract: Disposition of uric acid upon administration of ofloxacin (O) alone and in combination with other anti-tuberculosis drugs, rifampicin (R), isoniazid (H) and pyrazinamide (Z) was studied. Twelve male healthy volunteers were investigated on four different occasions with the four drugs alone or in combinations. A partially balanced incomplete block design was adopted and the subjects were randomly allocated to each group. Uric acid concentration in urine samples excreted over 0-8 hr, were determined after coding the samples. There was significant decrease in the group receiving Z when compared to other groups. Though there was a decrease in uric acid excretion in the group receiving O, it was not statistically significant. Rifampicin and H seem to increase the uric acid excretion. The incidence of arthralgia was mainly due to Z and not due to either O or other drugs in the treatment of pulmonary tuberculosis. Page(s): 323-325