NOPR Collection:

Anti-nociceptive effect of synthesized di-hydroxy flavones: Possible mechanism

2013-11-15T16:44:46Z

Title: Anti-nociceptive effect of synthesized di-hydroxy flavones: Possible mechanism Authors: Girija, K; Reddy, M Kannappa; Viswanathan, S Abstract: Renewed interest on the research on the flavonoids is gaining more importance. Earlier literature on flavonoids indicated a significant anti-nociceptive action for flavones and mono-substituted flavones. However, they exhibited a ceiling effect. The present study was undertaken by new synthesizing six disubstituted flavones (DHFs) since poly substituted ones are expected to produce more potent effect. Their anti-nociceptive effect and the role of opioid involvement were studied using acetic acid induced abdominal constriction assay. All the six DHFs administered in elicited a dose related inhibition of abdominal constructions indicating the presence of the anti-nociceptive response. However, these substances also showed a similar ceiling effect. Like other flavonoid substances, they also utilized opioid pathways. It is suggested that these newly synthesized DHFs can be included along with other flavonoids while attempting clinical trial for analgesic use. Page(s): 1314-1316

Effect of whole body gamma radiation on hepatic LDH activity, lactate, pyruvate concentration and rate of oxygen consumption in Bufo melanostictus

2013-11-14T16:45:07Z

Title: Effect of whole body gamma radiation on hepatic LDH activity, lactate, pyruvate concentration and rate of oxygen consumption in Bufo melanostictus Authors: Mishra, J; Mittra, B; Mittra, A Abstract: Whole body CO⁶⁰ gamma radiation induced changes in lactic dehydrogenase (LDH) activity, pyruvate, lactate content and rate of oxygen (O₂) consumption in a tropical hibernating anuran (Bufo melanostictus). In 3.5 and 7 Gy treated groups, a significant increase in LDH activity and lactate/ pyruvate ratio was observed, whereas a significant decrease in O₂ consumption rate was observed in treated animals o n post-irradiation day (PID) 1 ,5 and 10. Increase in LDH activity was observed on PID-1 in both the treated groups, reached to a peak on PID-5 in 7 Gy treated group and then declined on PID- 10. Page(s): 1310-1313

Impact of feeding ethanolic extracts of Achyranthes aspera Linn. on reproductive functions in male rats

2013-11-15T16:44:39Z

Title: Impact of feeding ethanolic extracts of Achyranthes aspera Linn. on reproductive functions in male rats Authors: Sandhyakumary, K; Boby, R G; Indira, M Abstract: Feeding 50% ethanolic extract of A. aspera to male rats resulted in reduced sperm counts, weight of epididymis, serum level of testosterone and testicular activity of 3β-hydroxysteroid dehydrogenase, while motility of the sperm and activity of the HMG CoA reductase were not affected. Cholesterol level in the testis, incorporation of labeled acetate into cholesterol, 17-ketosteroids in urine and hepatic and fecal bile acids were increased. The results suggest that ethanolic extract of A. aspera caused reproductive toxicity in male rats and the action may be by suppressing the synthesis of androgen. Page(s): 1307-1309

Storage excretion in the Indian apple snail, Pila globosa (Swainson), during aestivation

2013-11-14T16:45:46Z

Title: Storage excretion in the Indian apple snail, Pila globosa (Swainson), during aestivation Authors: Athawale, Madhura S; Reddy, S Raghupathi Rami Abstract: Uric acid accumulates in several tissues of the Indian apple snail, P. globosa, during aestivation, This accumulation is particularly high in the foot muscle and reproductive organs. Since the kidney, a tiny organ in the snail, has only a limited capacity to store uric acid, extrarenal tissues are used as storage depots of uric acid during aestivation. It is suggested that the aestivating snail, faced with a cleidoic situation, resorts to storage excretion, a phenomenon well documented in insects. Page(s): 1304-1306