NOPR Collection:http://nopr.niscpr.res.in/handle/123456789/3182026-10-09T21:47:40Z2026-10-09T21:47:40ZModel study on the sequence specific stacking by chromophore of an anticancer drug, acridine carboxamide with base pairs of DNAParajuli, RaghabSarma, Rajib LochanDas, Manas LochanMedhi, Chttp://nopr.niscpr.res.in/handle/123456789/38532009-04-16T16:30:11Z2007-09-01T00:00:00ZTitle: Model study on the sequence specific stacking by chromophore of an anticancer drug, acridine carboxamide with base pairs of DNA
Authors: Parajuli, Raghab; Sarma, Rajib Lochan; Das, Manas Lochan; Medhi, C
Abstract: The study on the sequence specific binding of acridine-4-carboxamides with DNA has been an important topic in the design of new drugs. It has been known that the anticancer properties of acridine-2, acridine-3 and acridine-4-carboxamides are significantly different. So the sequence specific binding of these drugs can be monitored from the intercalative mode of binding by chromophores within DNA. The stacking energies obtained from ab initio, MP2 and DFT methods have been used to understand the sequence preference intercalation by chromophore. Among these drugs, the acridine-4-carboxamide shows maximum stacking with GC base pair in spite of acquiring high potency, but the stacking energy of this drug with AT base pair is not so small. The conformation of carboxamide side chain in acridine-4-carboxamide does not lie in the same plane of chromophore, and also the orientation of side chain in acridine-2 and acridine-3 carboxamides is different from that of acridine-4-carboxamide.
Page(s): 1483-14942007-09-01T00:00:00ZReactivity pattern of in situ generated tetraethylammoniun superoxide with some flavonoidsSingh, Krishna NandKumar, Rajeshhttp://nopr.niscpr.res.in/handle/123456789/7082008-04-04T04:30:25Z2007-09-01T00:00:00ZTitle: Reactivity pattern of in situ generated tetraethylammoniun superoxide with some flavonoids
Authors: Singh, Krishna Nand; Kumar, Rajesh
Abstract: A number of flavonoids have been allowed to react under the mild reaction conditions of tetraethylammonium superoxide in dry dimethylformamide at room temperature. As an outcome,
3-hydroxyflavones 1a-c undergo oxidative ring cleavage to afford 2-benzoyloxyphenylglyoxylic acids 2a-c, whereas the substrates 1d-f result in the formation of acids 2d-f alongwith 3d-f.
Page(s): 1554-15572007-09-01T00:00:00ZEnvironmentally benign approach to imidazole 2-thionesKidwai, MazaahirKukreja, ShuchiRastogi, ShwetaSinghal, Kavitahttp://nopr.niscpr.res.in/handle/123456789/7072008-04-08T04:30:31Z2007-09-01T00:00:00ZTitle: Environmentally benign approach to imidazole 2-thiones
Authors: Kidwai, Mazaahir; Kukreja, Shuchi; Rastogi, Shweta; Singhal, Kavita
Abstract: An ecofriendly synthesis of some novel 1,4,5-triarylimidazole-2-thiones/1,3,4,5-tetraarylimidazole-2-thiones is described. The reaction involves condensation of benzoin with various readily accessible N-substituted thioureas/N,N'-disubstituted thioureas under microwave over recyclable inorganic solid support. This methodology eliminates the usage of solvent and external catalyst in the reaction step and reduces the reaction time from hours to minutes along with remarkable yield enhancement. In addition versatility of various solid supports as catalyst is also studied.
Page(s): 1549-15532007-09-01T00:00:00ZAn efficient, simple, one pot synthesis of dihydropyrimidine-2(1H)ones using phosphorus pentoxideDeshmukh, M BAnbhule, Prashant VJadhav, S DMali, A RJagtap, S SDeshmukh, S Ahttp://nopr.niscpr.res.in/handle/123456789/7052008-04-04T04:30:24Z2007-09-01T00:00:00ZTitle: An efficient, simple, one pot synthesis of dihydropyrimidine-2(1H)ones using phosphorus pentoxide
Authors: Deshmukh, M B; Anbhule, Prashant V; Jadhav, S D; Mali, A R; Jagtap, S S; Deshmukh, S A
Abstract: Phosphorus pentoxide has been found to be a mild and efficient reagent for synthesis of dihydropyrimidones and its corresponding thio-analoges in refluxing ethanol.
Page(s): 1545-15482007-09-01T00:00:00Z