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Two directional approach to spirocycles containing bicyclo[2.2.2]octane system via a [2+2+2] co-trimerization and Diels-Alder reaction

2017-12-22T06:22:56Z

Title: Two directional approach to spirocycles containing bicyclo[2.2.2]octane system via a [2+2+2] co-trimerization and Diels-Alder reaction Authors: Kotha, Sambasivarao; Saifuddin, Mohammad; Ali, Rashid; Shirbhate, Mukesh E; Sreevani, Gaddamedi Abstract: A simple and atom economic/step economic route for the synthesis of bis-armed spirocycles including bis-armed spirosulfone derivative containing bicyclo[2.2.2]octane ring system by utilizing a MW assisted Mo(CO)₆ catalyzed two-directional [2+2+2] co-trimerization and the [4+2] cycloaddition reaction as key steps, is reported. Page(s): 1231-1236

Environmentally benign synthesis and anti-mycobacterial evaluation of 9,10-dihydro-4-methyl-chromeno[8,7-e][1,3]oxazin-2(8H)-one derivatives

2017-12-22T06:19:26Z

Title: Environmentally benign synthesis and anti-mycobacterial evaluation of 9,10-dihydro-4-methyl-chromeno[8,7-e][1,3]oxazin-2(8H)-one derivatives Authors: Mathew, Bijoy P; Tandon, Rashmi; Batra, Neha; Agarwal, Drishti; Bose, Mridula; Gupta, Rinkoo D; Nath, Mahendra Abstract: In the present study, a series of 9,10-dihydro-4-methyl-chromeno[8,7-e][1,3]oxazin-2(8H)-one derivatives (4a-j) have been synthesized by using one-pot Mannich type condensation cyclization reaction of 7-hydroxy-4-methylcoumarin, formaldehyde and primary amines in water at 80-90°C. These products have been characterized using various spectroscopic techniques (¹H and ¹³C NMR, IR, and MS) followed by evaluation of their in-vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv. The compounds 4g and 4h display the lowest MIC of 5 µg/mL and offer a remarkable viability of HEK-293 cells at the highest test concentration (100 μg/mL) in toxicity assay. Page(s): 1237-1242

Synthesis and antibacterial activity screening of N- and O-substituted quinolin-2-one acetamide derivatives

2017-12-22T06:12:13Z

Title: Synthesis and antibacterial activity screening of N- and O-substituted quinolin-2-one acetamide derivatives Authors: Chand, Karam; Yadav, Preeti; Prasad, Suchita; Sharma, Sunil K Abstract: A series of new quinolin-2-one acetamide derivatives have been synthesized and characterized; their antibacterial potential investigated, against three Gram-positive pathogenic strains namely Bacillus cereus, Bacillus subtilis and Staphylococcus aureus and four Gram-negative pathogenic strains namely Pseudomonas aeruginosa, Escherichia coli, Salmonella typhimurium and Klebsiella pneumoniae by disc diffusion assay at a concentration of 250 μg/disc. Two of these compounds, which are O-substituted quinolin-2-one acetamides exhibit moderate activity against six bacterial strains B. cereus, B. subtilis, S. aureus, P. aeruginosa, E. coli and S. typhimurium. Page(s): 1243-1250

1,6-Dihydroxy-3-methyl-9,10-anthraquinone: An anti-cancerous natural pigment from Cassia sophera Linn. (Caesalpiniaceae)

2017-12-22T06:05:40Z

Title: 1,6-Dihydroxy-3-methyl-9,10-anthraquinone: An anti-cancerous natural pigment from Cassia sophera Linn. (Caesalpiniaceae) Authors: Brahmachari, Goutam; Mondal, Avijit; Mondal, Sadhan; Modolo, Luzia Valentina; Fátima, Ângelo de; Ruiz, Ana Lúcia Tasca Góis; Carvalho, João Ernesto de Abstract: A biologically relevant natural pigment, 1,6-dihydroxy-3-methyl-9,10-anthraquinone 1, widely produced by fungus from Phoma genus, has been isolated from Cassia sophera Linn. (Caesalpiniaceae) roots and subjected to detailed spectral studies, including 1D- and 2D-NMR. The compound 1 inhibits the proliferation of several cancer cell lines at different extents, showing minor effects on the growth of non-tumorogenic keratinocyte cells. Page(s): 1251-1255