NOPR Collection:

Influence of Cooperation and Collaborative ICT in Knowledge Management

2018-06-04T06:26:08Z

Title: Influence of Cooperation and Collaborative ICT in Knowledge Management Authors: Peñalver, A J Briones; Santos, José António C; Conesa, J A Bernal; Santos, M Custódio Abstract: The purpose of the theoretical framework of this paper is to explain the cooperation processes designed for small-sized firms, allowing access to the knowledge of the organization and inter-company cooperation. Data from 236 companies of the Spanish defense industry were used. Analysis of the principal components which group together all the variables from the questionnaire is carried out in order to determine the factors which will be taken into consideration in the analysis of inferences of the theoretical propositions and working hypotheses. The confirmation statistics of the hypotheses have been achieved using a multinomial logistic model. Further exploration on how cooperation levels relate to each other and with existing uses of information technologies in large companies could help improve the rigor of the results. Finally, conclusions covering theoretical and empiric aspects are shown. Page(s): 313-317

Experimental Investigations on Machinability Measures of LM6

2018-06-04T06:23:44Z

Title: Experimental Investigations on Machinability Measures of LM6 Authors: Nataraj, M; Balasubramanian, K Abstract: Aluminium alloy LM6 is used for manufacturing of components in automobile and marine applications. However, LM6 alloying elements pose challenges to manufacturing industry because they cause difficulty while machining, and rapid tool wear occurs due to the presence of high silicon content. Moreover LM6 strength falls down rapidly at elevated temperatures. In view of the above fact, engineers have focused their research on LM6 by adding suitable reinforcement particulates to develop metal matrix composites with LM6 as matrix. This research work discusses the method of optimising the technological data like machining-velocity, feed per revolution, machining-depth and insert nose radius in order to achieve better surface for LM6. It also investigates the influence of machining variables on surface roughness and the machinability measures such as resultant force, specific cutting pressure and co-efficient of friction between work-piece and tool. The study reveals that 0.8 mm nose radius insert gives better result and moreover interactions of feed per revolution and machining-depth have a noteworthy influence on surface finish. The optimal turning process variables are in close conformity with experimental results. The machinability measure analyses are useful in the prediction of machining performance as it more sensitive in reflecting the machining performance. Page(s): 318-324

Electric Discharge Drilling of Hybrid Metal Matrix Composites using Different Tool Electrodes

2018-06-04T06:20:16Z

Title: Electric Discharge Drilling of Hybrid Metal Matrix Composites using Different Tool Electrodes Authors: Kachhap, S; Singh, A; Debnath, K Abstract: In this paper, the machinability characteristics of hybrid metal matrix composites (HMMCs) (Al6063/SiC/Gr/Al₂O₃) have been experimentally evaluated during electro-discharge drilling (EDD) with solid and hollow tool electrodes made of copper and brass. The influence of different parameter such as (i) discharge current, (ii) tool material, and (iii) tool geometry on (i) material removal rate (MRR) and (ii) tool wear rate (TWR) has been experimentally investigated. The end face wear of the tool electrode has also been presented with the help of microscopy imaging. The results of the experimental investigation indicated that the MRR is improved with hollow brass tool electrode and TWR is reduced with solid copper tool electrode during EDD of developed composites. Page(s): 325-329

In vitro Assessment of Selected Benzoic Acid Derivatives as Anti-Inflammatory Compounds

2018-06-04T06:12:56Z

Title: In vitro Assessment of Selected Benzoic Acid Derivatives as Anti-Inflammatory Compounds Authors: Tomy, M J; Sharanya, C S; Mahapatra, D K; Suresh, K I; Sabu, A; Haridas, M Abstract: Inflammation is a major reason of pathophysiology of several diseases, causing a number of disarrays. The present research involved exploring inhibition of soybean 5-lipoxygenase (5-LOX) by various benzoic acid derivatives (eudesmic acid, veratric acid, cumic acid, and syringic acid) and their kinetics studies, comparing with vanillin as a standard reference. Isothermal titration calorimetry (ITC) was performed to determine kinetics of the biomolecular interactions. Further, molecular docking studies were performed using GLIDE module of Schrodinger software to determine the inter-molecular interactions between the ligand and the target. Result underlined that four of the investigated derivatives exhibited potent inhibition of 5-LOX in a competitive manner with IC₅₀ values <60 µM. ITC study demonstrated that all derivatives bind effectively with a single domain of the target. Molecular docking studies revealed that all the four candidates displayed good interaction with the target. As found from Glide scores, veratric acid interacted stronger than other derivatives (GLIDE Score of -10.72 kcal/mol), forming two hydrogen bonds with residues GLN514 and GLN716, quite similar to the standard reference. ITC and GLIDE score analyses showed difference in the binding strength of the derivatives. This study would help in developing novel inhibitors, anti-inflammation as well as understanding mechanism(s) of ligand-enzyme interaction. Page(s): 330-336