NOPR Collection:

Synthesis and characterization of Schiff bases of pyrazole aldehyde and their metal complexes of Cu(II), Ni(II) and Co(II)

2021-03-03T04:24:06Z

Title: Synthesis and characterization of Schiff bases of pyrazole aldehyde and their metal complexes of Cu(II), Ni(II) and Co(II) Authors: Odedra, Pratap; Rojivadiya, Atul Abstract: Synthesis of some novel metal complex of different transition metal likes Co, Cu and Ni have been carried out with (E)-5-(3-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)acryloyl)-2-hydroxybenzamide ligand with the appropriate metal salts i.e. Co(CH₃COO)₂·6H₂O, Ni(CH₃COO)₂·6H₂O and Cu(CH₃COO)₂·2H₂O. The structure conformation of ligand molecule is done by using various spectroscopic techniques such as ¹H NMR, IR and mass. The thermal analyses of synthesized metal complexes are carried out by TGA and DTA under inert gas atmosphere. Further, antimicrobial activity of these synthesized metal complexes are also checked against some selected bacterial and fungal strains and good to moderate biological activity of the metal complexes against selected bacterial and fungal strains are observed in DMF and DMSO solvents. Page(s): 332-340

Synthesis, characterization, antimicrobial and DNA cleavage study of organoantimony(III) and organoarsenic(III) complexes with monofunctional bidentate Schiff base

2021-03-03T04:22:03Z

Title: Synthesis, characterization, antimicrobial and DNA cleavage study of organoantimony(III) and organoarsenic(III) complexes with monofunctional bidentate Schiff base Authors: Kumari, Anita; Meena, Ramhari; Singh, R V; Fahmi, Nighat Abstract: A series of mononuclear organoantimony(III) and organoarsenic(III) complexes of bidentate Schiff base [2-(2-fluorophenyl)methylene]hydrazinecarbothioamide (LH) have been synthesized by the reaction of Ph₃Sb and Ph₃As with ligand in 1:1 and 1:2 molar ratios. All the synthesized compounds were characterized by elemental analyses, melting point determinations and a combination of electronic, IR, ¹H NMR, ¹³C NMR and X-ray diffraction studies. These studies have shown that the ligand coordinated to the antimony and arsenic in a monobasic bidentate manner through sulfur and nitrogen donor system. Thus, a tetra-coordinated and a penta-coordinated environment around the antimony and arsenic atom have been proposed for 1:1 and 1:2 complexes, respectively. All the complexes and parent ligand have been screened for their antimicrobial activity on several pathogenic fungi and bacteria and are found to possess appreciable fungicidal and bactericidal properties. Further, the ligand and its corresponding metal complexes have been tested for their DNA cleavage activity by the gel electrophoresis and the results revealed that the complexes are better cleaving agents than ligand. Page(s): 341-347

One pot synthesis of luminescent Mn doped ZnSe nanoparticles and their silica based water dispersible formulation for targeted delivery of doxorubicin

2021-03-03T04:19:58Z

Title: One pot synthesis of luminescent Mn doped ZnSe nanoparticles and their silica based water dispersible formulation for targeted delivery of doxorubicin Authors: Sharma, K Shitaljit; Ali, Ashraf; Phadnis, Prasad P; Kumar, Chandan; Ballal, Anand; Dash, Ashutosh; Vatsa, Rajesh K Abstract: The manganese doped zinc selenide nanoparticles (ZnSe:Mn NPs) have been synthesized by thermolysis method using oleic acid and oleylamine as capping agents, and 1-octadecene as solvent. Coating of mesoporous silica is done on ZnSe:Mn (ZnSe:Mn@mSilica) which is further functionalized with amine functional groups by treating with (3-aminopropyl)trimethoxysilane. Further pegylation is done to achieve water dispersibility by conjugating carboxyl groups of poly(ethylene glycol) diacid with the amine groups. These pegylated NPs are subsequently treated with ethylenediamine followed by acrylic acid. Conjugation of tris-(hydroxymethyl-aminomethane) is performed by Michael-type addition reaction to afford ZnSe:Mn@mSilica-PEG-Tris-OH. These tris functionalized NPs have exhibited broad emission ranging from 590-620 nm that is an indicative for their suitability in diagnosis and monitoring progress of cancer treatment. To explore the usefulness of increased surface area because of mesoporosity, doxorubicin is loaded on ZnSe:Mn@mSilica-PEG-Tris-OH NPs through silyl ether linkage and evaluated for cytotoxicity against WEHI-164 mouse fibrosarcoma and RAJI human hematopoietic origin cancer cell lines. A decrease in 12% of cell viability of WEHI-164 cells while 30% decrease in RAJI cell lines (IC₅₀ ≈ 45 nM) are observed. This shows that our formulation has more cytotoxic in RAJI cancer cell lines than that of WEHI-164 cancer cells. These results reveal that the formulation has potential for the application in drug delivery and diagnosis in chemotherapeutics. Page(s): 348-355

1D and 2D Cobalt(II) coordination polymers with dipicolinic acid ligands and photocatalytic CO2 reduction

2021-03-03T04:17:03Z

Title: 1D and 2D Cobalt(II) coordination polymers with dipicolinic acid ligands and photocatalytic CO2 reduction Authors: Zhu, Han; Xu, Quanqing; Kou, Junfeng; Liu, Fengyi Abstract: 1D and 2D cobalt(II) coordination polymers, [Co(2,3-dpc)(H₂O)₂]_n (1), [Co(2,5-dpc)(H₂O)₃]_n (2) and [Co(3,5-dpc)(H₂O)₂]_n (3) (dpc = dipicolinic acid dianion) have been successfully synthesized by reaction of dipicolinic acid ligands with CoF₂in aqueous methanolic solution under hydrothermal conditions. High resolution mass spectroscopy investigation reveals the forming process of CO during the photocatalytic CO₂ reduction and the plausible mechanisms are proposed. Page(s): 356-360