NOPR Collection:http://nopr.niscpr.res.in/handle/123456789/581062026-10-10T14:20:47Z2026-10-10T14:20:47ZMolecularly imprinted electrochemical sensor based on electrode modified by functionalized carbon nanotube for selective detection of uric acidZhao, YongfuLiu, HuiLv, WenWang, Yanhuanhttp://nopr.niscpr.res.in/handle/123456789/581122021-09-17T07:19:20Z2021-09-01T00:00:00ZTitle: Molecularly imprinted electrochemical sensor based on electrode modified by functionalized carbon nanotube for selective detection of uric acid
Authors: Zhao, Yongfu; Liu, Hui; Lv, Wen; Wang, Yanhuan
Abstract: In this study, we have developed a novel biomimetic electrochemical sensor sensitized with functionalized carbon nanotubes using a molecularly imprinted film as a recognition element for the rapid detection of uric acid. Using K<sub>3</sub>[Fe(CN)<sub>6</sub>] as a probe, uric acid imprinted films on electrodes are characterized by voltammetry measurements and electrochemical impedance spectroscopy. The optimizations of experimental steps are conducted by cyclic voltammetry and differential pulse voltammetry. When the imprinted sensor is immersed in the solution containing a certain concentration of uric acid and incubated for a period of time, the oxidation peak current of K<sub>3</sub>[Fe(CN)<sub>6</sub>] decreases with the increase of uric acid concentration. Under optimal conditions, the peak current of K<sub>3</sub>[Fe(CN)<sub>6</sub>] has a good linear relationship with uric acid concentration at range from 0.1 μM to 3.3 μM with the detection limit of 0.03 μM. The proposed sensor shows high selectivity for rapid detection of uric acid in human serum samples.
Page(s): 1151-11582021-09-01T00:00:00ZImpact of sodium ion impregnation on the photocatalytic hydrogen evolution activities of anatase/rutile mixed phase TiO<sub>2</sub> nanomaterialsP, Sruthy RajK R, PrathyushaM R, ResmiParayil, Sreenivasan Koliyathttp://nopr.niscpr.res.in/handle/123456789/581112021-09-17T07:15:08Z2021-09-01T00:00:00ZTitle: Impact of sodium ion impregnation on the photocatalytic hydrogen evolution activities of anatase/rutile mixed phase TiO<sub>2</sub> nanomaterials
Authors: P, Sruthy Raj; K R, Prathyusha; M R, Resmi; Parayil, Sreenivasan Koliyat
Abstract: Sodium ion impregnated anatase/rutile mixed phase TiO<sub>2</sub> material has been synthesised by sol-gel method and characterised for understanding the solar hydrogen production activities. The presence of sodium ion can influence the crystallinity, crystallite size and photocatalytic efficiency of mixed phase TiO<sub>2</sub>. The hydrogen evolution activities of the sodium impregnated TiO<sub>2</sub> and bare TiO<sub>2</sub> materials are compared by calculating the yield of H<sub>2</sub> gas evolved from the dissociation of H<sub>2</sub>O. Even though the presence of rutile/anatase mixed phase TiO<sub>2</sub> is suitable for hydrogen evolution under UV/visible light irradiation, it is found that bare TiO<sub>2</sub> can act as a good catalyst and gives a hydrogen evolution value of 134 μmol after 5 h of irradiation from 20 mg of the catalyst. However, the sodium impregnated TiO<sub>2</sub> material show lower hydrogen evolution as compared to bare TiO<sub>2</sub> and a value of 34 μmol under similar experimental condition. The variation in hydrogen evolution may be exhibited due to high crystallinity, large crystallite size and higher percentage of the rutile phase in bare TiO<sub>2</sub> compared to sodium impregnated TiO<sub>2</sub> material. This study will be helpful for understanding the effect of alkali metal ion in metal oxide semiconductor and further understanding their detrimental effect on photocatalytic water splitting and related applications.
Page(s): 1159-11632021-09-01T00:00:00ZInteraction studies of diglycine with aqueous solutions of sulphathiazole drug at different temperaturesPal, AmalenduSoni, Surbhihttp://nopr.niscpr.res.in/handle/123456789/581102021-09-17T07:04:20Z2021-09-01T00:00:00ZTitle: Interaction studies of diglycine with aqueous solutions of sulphathiazole drug at different temperatures
Authors: Pal, Amalendu; Soni, Surbhi
Abstract: The interactions of diglycine with sulphathiazole drug as a function of temperatures have been studied using volumetric
and acoustic parameters. Densities and speeds of sound of diglycine in (0.001, 0.002, 0.005 and 0.010) mol·kg<sup>-1</sup> aqueous
solutions of sulphathiazole drug have been measured at five different temperatures of (288.15, 293.15, 298.15, 303.15 and
308.15) K under 0.1 MPa pressure. From density data, the apparent molar volume, the partial molar volume and the standard
partial molar volume of transfer for glycine from water to aqueous sulphathiazole solutions have been calculated. Partial
molar isentropic compression and partial molar isentropic compression of transfer have been calculated from the speed of
sound data. Transfer parameters by using cosphere overlap model have been explained on the basis of ionic-hydrophilic,
hydrophilic-hydrophilic, hydrophilic-hydrophobic and hydrophobic-hydrophobic group interactions. To draw the conclusion
from the volumetric and acoustic data, limiting apparent molar expansion as well as the hydration numbers have been
studied. The calculated values of thermal expansion coefficient have small and positive values. All of these derived or
calculated parameters are explained to understand the solvation behaviour and various types of interactions born in the
ternary solutions of (dipeptide + drug + water) due to change in structure. We have also attempted to examine the
temperature and concentration dependence of such interactions.
Page(s): 1164-11712021-09-01T00:00:00ZSpectroscopic characterization and electronic structure analysis of Linagliptin by DFT methodBalasubramanian, VijayakumarVenkatachalam, SathyanarayanamoorthiVenu, KannappanPalanisamy, Naresh Kumarhttp://nopr.niscpr.res.in/handle/123456789/581092021-09-17T07:00:50Z2021-09-01T00:00:00ZTitle: Spectroscopic characterization and electronic structure analysis of Linagliptin by DFT method
Authors: Balasubramanian, Vijayakumar; Venkatachalam, Sathyanarayanamoorthi; Venu, Kannappan; Palanisamy, Naresh Kumar
Abstract: The spectroscopic and electronic characterization of the molecule Linagliptin (LGP), one of the most important type-2 diabetes drugs, has been studied by the quantum mechanical method. The optimized molecular structure, electronic properties, dipole moment, rotational constants and important thermodynamic parameters of LGP molecule have been computed using HF (Hartree-Fock) and DFT (density functional theory) methods with 6-311++G (d,p) basis set. Spectroscopic properties such as FT-IR, Raman and absorption spectra are calculated in different solvents by the TD-DFT method and compared with the experimental data. The various types of intra-molecular interactions such as conjugative, hyper conjugative and other structural effects are analyzed from natural bonds orbitals of LGP. The relationship between linear polarizability and refractive index is used to describe the polarization behaviour of LGP in different solvents. The electronic charge density at different positions and reactivity descriptors of LGP are used in identifying the site of drug interaction. The various intra-molecular interactions are explained in terms of HOMO and LUMO energies. Mulliken charges and thermodynamic properties of LGP are also discussed.
Page(s): 1172-11802021-09-01T00:00:00Z