NOPR Collection:http://nopr.niscpr.res.in/handle/123456789/590322026-10-11T15:37:24Z2026-10-11T15:37:24ZSynthesis of curcumin based imidazo[2,1-b]thiazole derivatives and their biological evaluation as antiproliferative agentsMallikarjun, GRaju, A KrishnamYadav, J Shttp://nopr.niscpr.res.in/handle/123456789/590442022-02-01T11:51:39Z2022-01-01T00:00:00ZTitle: Synthesis of curcumin based imidazo[2,1-b]thiazole derivatives and their biological evaluation as antiproliferative agents
Authors: Mallikarjun, G; Raju, A Krishnam; Yadav, J S
Abstract: Motivated by the antiproliferative potential of curcumin and imidazothiazoles, a series of curcumin based imidazo[2,1-b]
thiazole derivatives have been prepared, characterized and evaluated for their anticancer activity against various human
cancer cell lines. These synthesized compounds have been found to have appreciable to moderate activity. Consequently,
compounds 8a and 8g display noteworthy cytotoxicity with IC50 values of 7.2 μM and 4.7 μM, respectively, against A549
cell line. Furthermore, compounds 8a, 8b and 8g exhibit substantial cytotoxicity with IC50 values ranging between 9.1 μM to
9.9 μM respectively, against HeLa cell line. Interestingly, compounds 8a and 8g exhibit appreciable cytotoxicity with IC50
values ranging between 7.5 μM to 8.7 μM respectively, against DU145 cancer cell line. Overall, four compunds (8a, 8b, 8g
and 8h) demonstrate IC50 values less than 10 μM against selected human cancer cell lines. They could be taken further for
investigation of their mode of action and other parameters.
Page(s): 13-202022-01-01T00:00:00ZSynthesis of photoactivable Pt(IV) prodrug loaded on NaYF4 based upconversion nanoparticles functionalized with 2-deoxy-D-glucose and its evaluation for targeted cancer therapySharma, K ShitaljitTiewsoh, LodestarbornDubey, Akhil KPhadnis, Prasad PSudarsan, VVatsa, Rajesh Khttp://nopr.niscpr.res.in/handle/123456789/590432022-03-28T06:23:29Z2022-01-01T00:00:00ZTitle: Synthesis of photoactivable Pt(IV) prodrug loaded on NaYF4 based upconversion nanoparticles functionalized with 2-deoxy-D-glucose and its evaluation for targeted cancer therapy
Authors: Sharma, K Shitaljit; Tiewsoh, Lodestarborn; Dubey, Akhil K; Phadnis, Prasad P; Sudarsan, V; Vatsa, Rajesh K
Abstract: Nano-formulation based on Tm, Yb doped NaYF4 upconversion nanoparticles (UCNPs) functionalized with 2-deoxy-D-glucose have been synthesized to load the photoactivable Pt(IV) prodrug, cis-[PtI2(NH3)2(OCOCH2CH2COOH)2]. The Pt(IV) prodrug has been synthesized by oxidation of cis-[PtI2(NH3)2] to [PtI2(OH)2(NH3)2] and its further treatment with succinic anhydride. It is loaded through ester bond formation between the carboxyl groups of Pt(IV) prodrug with hydroxyl groups of 2-deoxy-D-glucose (2-DG) coated on UCNPs. The cytotoxicity of formulation after exposing to 385 nm UV light and in absence of light is evaluated against MCF-7 cell lines by MTT assay. The results have revealed enhanced cytotoxicity of UV exposed nano-formulation. Additionally, the clonogenic assay has exhibited the decrease in plating efficiency as inferred from decreased surviving fraction around 20% only for UV activated formulation as compared to formulation in dark, as well as merely Pt(IV) prodrug. These results are indicative that more internalization of the formulation inside the cancer cells was achieved due to the presence of 2-DG rendering more efficiency to kill cancer cells.
Page(s): 21-302022-01-01T00:00:00ZA new Ln(III) coordination polymer constructed from a hexadentate triazine ligand: Treatment activity and nursing value for ovarian cancerWang, XiaoqinZhang, DuoyiLi, XinWang, Qiminghttp://nopr.niscpr.res.in/handle/123456789/590422022-02-01T11:46:21Z2022-01-01T00:00:00ZTitle: A new Ln(III) coordination polymer constructed from a hexadentate triazine ligand: Treatment activity and nursing value for ovarian cancer
Authors: Wang, Xiaoqin; Zhang, Duoyi; Li, Xin; Wang, Qiming
Abstract: In this current paper, a 3D lanthanide (Ln) coordination polymer (CP), compound 1 with a chemical formula of
[(NH2(Me)2)]6ꞏ[Gd3(TATAT)2(μ2-O)1.5]ꞏ3EtOHꞏ7.5H2O is synthesized with the reaction between GdCl3ꞏ6H2O and 5,5′,5′′-
(1,3,5-triazine-2,4,6-triyltriimino)tris(azanediyl) triisophthalate (H6TATAT). Its treatment activity and nursing value against
ovarian cancer is tested and the associated mechanism is analyzed simultaneously. At first, the CCK-8 detection is
implemented to determine the suppression activity of compound 1 against the cell viability of ovarian cancer after treated
via our compound. Furthermore, in order to detect the relative expression for the estrogen receptor on cells of ovarian
cancer, real time RT-PCR is carried out.
Page(s): 31-362022-01-01T00:00:00ZA 3D Co(II) compound: Crystal structure and protective activity on chronic nephritisShi, Xiu-ZhenGuo, Ai-LiFu, KaiHe, YanLi, QinLuo, Qionghttp://nopr.niscpr.res.in/handle/123456789/590412022-02-01T11:44:28Z2022-01-01T00:00:00ZTitle: A 3D Co(II) compound: Crystal structure and protective activity on chronic nephritis
Authors: Shi, Xiu-Zhen; Guo, Ai-Li; Fu, Kai; He, Yan; Li, Qin; Luo, Qiong
Abstract: In the current study, via applying a mixed-ligand strategy, a Co(II) coordination polymer that is, {[Co4(3-dpyb)2
(odpa)2(H2O)3]ꞏ4H2O}n (1) [where 3-dpyb is N,N′-bis(3-pyridinecarboxamide)-1,4-butane, and H4odpa represents
4,4′-oxydiphthalic acid] is produced through reaction between two organic ligands and Co(NO3)2ꞏ6H2O in the water and
DMF mixed solvents. For the treatment of chronic nephritis, real time RT-PCR is employed for measuring the AMPK
signaling pathway activation, and ELISA detection kit is applied to evaluate inflammatory cytokines content released into
plasma. Computer simulation has revealed that the activity of the proposed candidate is only from the carboxyl function
groups, however, nitrogen atoms from both amide and pyridine groups only showed limited activity to the protein.
Page(s): 37-422022-01-01T00:00:00Z