NOPR Collection:http://nopr.niscpr.res.in/handle/123456789/595372026-10-11T22:16:19Z2026-10-11T22:16:19ZCarboxyl functionalized graphene oxide based electrochemical sensor for detection of dopamine in presence of ascorbic acid, uric acid and synthetic cerebrospinal fluidBordoloi, PriyakshiDas, Diganta Kumarhttp://nopr.niscpr.res.in/handle/123456789/595492022-04-19T07:31:52Z2022-04-01T00:00:00ZTitle: Carboxyl functionalized graphene oxide based electrochemical sensor for detection of dopamine in presence of ascorbic acid, uric acid and synthetic cerebrospinal fluid
Authors: Bordoloi, Priyakshi; Das, Diganta Kumar
Abstract: Dopamine is an important neurotransmitter and plays a vital role in the proper functioning of human metabolism.
Therefore, fabrication of a sensitive sensor for the detection of dopamine is crucial. The work reports detection of dopamine
in presence of interfering ascorbic acid, uric acid, Na+, K+, Ca2+, urea and glucose. The linear range for the detection of
dopamine is observed from 1.07×10-4 M to 2.19×10-4 M in presence of 1.00×10-3 M ascorbic acid and 1.00×10-3 M uric acid.
The detection limit is estimated to be 1.46×10-8 M.
Page(s): 365-3692022-04-01T00:00:00ZSAR-based approach to explore in silico ferrocene analogues as the potential inhibitors of major viral proteins of SARS-CoV-2 virus and human Ca2+-channel blockerPal, MaynakMusib, DulalRoy, Mithunhttp://nopr.niscpr.res.in/handle/123456789/595482022-04-19T07:27:13Z2022-04-01T00:00:00ZTitle: SAR-based approach to explore in silico ferrocene analogues as the potential inhibitors of major viral proteins of SARS-CoV-2 virus and human Ca2+-channel blocker
Authors: Pal, Maynak; Musib, Dulal; Roy, Mithun
Abstract: Amid the pandemic COVID-19, there is a desperate and urgent need for a therapeutic solution for COVID-19. Our present studies have adapted the SAR-based approach to explore in silico several selected ferrocene-based complexes as the potential inhibitors of the major viral proteins (Spike, RdRp, Mpro, N protein) of the SARS-CoV-2 virus. The SAR-based molecular docking studies have revealed that compound 1 is the strongest inhibitor of the major viral proteins with a binding energy of >9.0 kcal/mol. Compound 1 is also able to inhibit the human Ca2+ channel and thereby potentially able to prevent the strong inflammatory signalling cascades causing severe respiratory distress to the COVID-19 patients. Overall, our computational studies explored ferrocene-based compounds as the emerging multi-targeting therapeutic solution for COVID-19 by inhibiting viral replication as well as modulating the inflammatory signalling cascades.
Page(s): 370-3842022-04-01T00:00:00ZMicrowave assisted synthesis of heterocyclic metal complexes and evaluation of their in vitro anticancer activity against oral cancer cells, antioxidant and molecular docking studyAli, SabirSingh, VandnaTripathi, Vishwashttp://nopr.niscpr.res.in/handle/123456789/595472022-04-19T06:46:46Z2022-04-01T00:00:00ZTitle: Microwave assisted synthesis of heterocyclic metal complexes and evaluation of their in vitro anticancer activity against oral cancer cells, antioxidant and molecular docking study
Authors: Ali, Sabir; Singh, Vandna; Tripathi, Vishwas
Abstract: Heterocyclic complexes of Cr(III) and Fe(III) have been synthesized through condensation of succinic dihydrazide with 5-chloroindoline-2,3-dione in alcoholic medium by template method in 1:1:1 ratio using microwave irradiation technique. On the basis of physicochemical and spectroscopic techniques the geometry of the complexes are identified as octahedral. The synthesized complexes are screened for their bioactivity. In vitro anticancer activity was evaluated against HNSC cell line and antioxidant activity is done by DPPH assay method. In-silico study is done by molecular docking with EGFR tyrosine kinase. The results show that synthesized compounds have significant anticancer as well as antioxidant property.
Page(s): 385-3912022-04-01T00:00:00ZKinetics of catalytic activities of micro amount of Ir(III) in oxidation of D(-) Galactose by N-bromosuccinimide in acidic homogeneous mediumSingh, Vinod KumarSingh, VineetaSingh, Vaishalihttp://nopr.niscpr.res.in/handle/123456789/595462022-04-19T06:44:45Z2022-04-01T00:00:00ZTitle: Kinetics of catalytic activities of micro amount of Ir(III) in oxidation of D(-) Galactose by N-bromosuccinimide in acidic homogeneous medium
Authors: Singh, Vinod Kumar; Singh, Vineeta; Singh, Vaishali
Abstract: It has been investigated how iridium(III) catalyses the oxidation of D(-)Galactose by N-bromosuccinimide (NBS) in an aqueous perchloric acid solution at 308 K. NBS kinetics is first-order, while galactose kinetics is zero-order. As a function of [Ir(III)], the reactions demonstrate first order at lower [Ir(III)] and zero-order behaviour at higher [Ir(III)]. On the rate of oxidation, inverse fractional-order has been reported in [H+], [Cl-] and [succinimide]. There is no difference in the rate of oxidation with changes in the ionic strength of the medium or with the addition of Hg(OAc)2 (a Br-ion scavenger). Galactonic acid has been identified as the major oxidation product of the process. It is possible to compute the activation parameters by utilizing the rate constants observed at four distinct temperature levels. For the sake of this research, it is hypothesised that HOBr and [IrCl5H2O]2-are both reactive species oxidants (i.e. NBS) as well as catalysts. It is very probable that the reaction mechanism for the oxidation of galactose by NBS is supported by current kinetic data, reaction stoichiometry, and product analysis.
Page(s): 392-3982022-04-01T00:00:00Z