NOPR Community:http://nopr.niscpr.res.in/handle/123456789/602026-10-05T09:42:06Z2026-10-05T09:42:06ZBenzothiazole analogues and their biological aspects: A ReviewPopli, Jyoti VKumbhare, Manoj RSurana, Ajay RBhalerao, Mrunal RAgrawal, Pranay Ahttp://nopr.niscpr.res.in/handle/123456789/586122021-12-15T11:17:09Z2021-12-01T00:00:00ZTitle: Benzothiazole analogues and their biological aspects: A Review
Authors: Popli, Jyoti V; Kumbhare, Manoj R; Surana, Ajay R; Bhalerao, Mrunal R; Agrawal, Pranay A
Abstract: Heterocyclic compounds analogues have attracted strong interest in medicinal chemistry due to their pharmacological
properties. Benzothiazole belongs to the heterocyclic class of bicyclic compounds. It is a combination of two rings six membered
and five membered and both the rings are responsible for the therapeutic activity. Different methods are used to synthesize
benzothiazole compounds and have been found to have numerous biological activities like – anticancer, antimicrobial,
anti-inflammatory, anti-leishmanial, antidiabetic activity. This review is mainly an attempt to present the work reported in literature
on pharmacological activity of benzothiazole compounds.
Page(s): 1659-16692021-12-01T00:00:00ZCrystal structure determination, molecular modeling and surface analysis studies of 2-(4,6-dihydropyren-3-yl)-1H-benzodimidazoleManickam, RJagan, RJagadeesan, GSrinivasan, Ghttp://nopr.niscpr.res.in/handle/123456789/586112021-12-15T11:11:23Z2021-12-01T00:00:00ZTitle: Crystal structure determination, molecular modeling and surface analysis studies of 2-(4,6-dihydropyren-3-yl)-1H-benzodimidazole
Authors: Manickam, R; Jagan, R; Jagadeesan, G; Srinivasan, G
Abstract: Benzoimidazole compound has been synthesized and structurally characterized by single crystal X-ray diffraction
studies, molecular docking and Hirshfeld surface analysis. The title compound C23 H14 N2 crystallizes in the Orthorhombic
crystal system with the crystallographic space group of Pna21 with cell parameters a = 9.4472(5)Å, b=9.0556(5)Å,
c=18.3755(11)Å, V=1572.03(15)Å3 and Z=4. The structure exhibits various intra and intermolecular interactions of the type
N-H...N. Molecular docking studies of benzoimidazole compound have been executed with Cancer Osaka Thyroid kinease
target protein which shows high binding affinity. In addition to this, Hirshfeld surface computational analysis have been
carried out to analysis the hydrogen bond interaction. The major intermolecular contacts contributing to the Hirshfeld
surface are H...H, H...N and H...C, respectively.
Page(s): 1652-16582021-12-01T00:00:00ZSynthesis, structure elucidation and antibacterial screening of some novel 1,3,4-oxadiazoline derivativesArshad, MohammadBeg, Md AmjadBhat, Abdul RAthar, Fareedahttp://nopr.niscpr.res.in/handle/123456789/586102021-12-15T11:07:53Z2021-12-01T00:00:00ZTitle: Synthesis, structure elucidation and antibacterial screening of some novel 1,3,4-oxadiazoline derivatives
Authors: Arshad, Mohammad; Beg, Md Amjad; Bhat, Abdul R; Athar, Fareeda
Abstract: Anovel sequence of 1,3,4-oxadiazoline derivatives has been synthesized with an endeavour to explore their consequence
on in vitro growth of microbes causing the microbial contagion. In vitro antimicrobial activity has been performed against
the Escherichia coli (E. coli) and Proteus mirabilis (P. mirabilis) which are Gram-negative (Gram-ve) and Staphylococcus
aureus (S. aureus) and Staphylococcus epidermidis (S. epidermis) which are Gram-positive (Gram+ve) by using disk
diffusion method. The minimum inhibitory concentration (MIC) has been distinguished by employing the double dilution
method. The result of percent inhibition area/µg of the compounds has been differentiated with the standard drug
“Ciprofloxacin”. Several compounds portray excellent activity as compared to the standard drug Ciprofloxacin while some
of them presented a considerable zone of inhibition. The evaluated compounds for cytotoxicity effects via Human
hepatocellular carcinoma (HepG2) cell line by MTT-assay and findings reveal that the experimental compounds display a
viability of ≥80% at 100 µM. In molecular docking studies, the 1,3,4-oxadiazoline derivatives demonstrate the ligandreceptor
interaction with amino acids which exist on the active sites of the peptide deformylase and the 1,3,4-oxadiazoline
derivatives exhibit their antibacterial potential as peptide deformylase inhibitors.
Page(s): 1636-16512021-12-01T00:00:00ZSynthesis, crystal structure and fluorescence spectrum of some new 1,2,3-triazolxanthen-3-one derivativesDong, Hong-RuJin, Chi-QiongChen, Zi-Baohttp://nopr.niscpr.res.in/handle/123456789/586092021-12-15T10:44:07Z2021-12-01T00:00:00ZTitle: Synthesis, crystal structure and fluorescence spectrum of some new 1,2,3-triazolxanthen-3-one derivatives
Authors: Dong, Hong-Ru; Jin, Chi-Qiong; Chen, Zi-Bao
Abstract: Some new compounds 9-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)-6-hydroxy-3H-xanthen-3-one 7a-j have been
synthesized for new fluorescence probe material. Their fluorescence and ultraviolet-visible spectra have been studied. Their
structures are established by MS, IR and 1H NMR spectral data. The structure of title compound 7c has been identified by
X-ray diffraction. C22H14C1N3O3, belongs to triclinic system, space group Pī with a = 8.296(4), b = 9.726(5), c = 11.976(6)
Å, α = 90.953(7), β = 105.081(7), γ = 100.693(8)º, V = 914.7(8)Å3, Z = 2, Dc = 1.466 Mg/m3, F(000) = 416.0 and μ = 0.240
mm–1. The title compound has a weaker inhibiting HIV-1 protease than indinavir.
Page(s): 1629-16352021-12-01T00:00:00Z