NOPR Collection:

Cytotoxic ent-kaurane diterpenoids from Isodon racemosa (Hemsl) Hara

2016-07-20T05:25:11Z

Title: Cytotoxic ent-kaurane diterpenoids from Isodon racemosa (Hemsl) Hara Authors: Ding, Lan; Liu, Guo-An; Wang, Lai Abstract: A new ent-kaurane diterpenoid racemosin A (1) and three known compounds, leukamenin E (2), glaucocalyxin A (3) and wangzaozin A (4), have been isolated from the leaves of Isodon racemosa (Hemsl) Hara. The new diterpenoid is identified as 14β-hydroxy-3β, 7α-acetoxy-ent-kaur-16-en-15-one on the basis of spectral data, especially by 2D NMR techniques. Compounds 1-4 show significant cytotoxic activity against Bel-7402 and HO-89! 0 cells in the range of 1.51-2.57 and 3.33-4.02 µg/mL, respectively. This may be due to the presence of conjugated exo-methylene systen in an ent-kaurane skeleton. Page(s): 548-551

Synthesis of pyrazolines, isoxazolines and aminopyrimidines as biological potent agents

2016-07-20T05:24:09Z

Title: Synthesis of pyrazolines, isoxazolines and aminopyrimidines as biological potent agents Authors: Solankee, Anjani; Thakor, Indrajit Abstract: Chalcones, 2-phenylamino-4-(4'-fluorophenylamino )-6-[4'-{3"-(phenyl/substituted phenyl/2"'- furanyl/3'"-pyridinyl)-2"- propenon-1"-y1} phenylamino]-s-triazines 6a-j have been prepared from ketone 5 based on s-triazine nucleus. These chalcones 6a-j on cyclisation with hydrazine hydrate, hydroxylamine hydrochloride and guanidine nitrate give the corresponding pyrazolines 7a-j, isoxazolines 8a-j and aminopyrirnidines 9a-j, respectively. Antimicrobial activities of all synthesized compounds have been performed by using cup-plate method against bacteria and by using poisoned food technique against fungi. The constitutions of newly synthesized compounds have been established on the basis of elemental analysis, IR and ¹H NMR spectral data. Page(s): 517-522

An efficient and chemoselective method for conversion of carbonyl compounds to 1,3-oxathiolanes with 2-mercaptoethanol catalyzed by TiCl₄-montmorillonitc

2016-07-20T05:23:15Z

Title: An efficient and chemoselective method for conversion of carbonyl compounds to 1,3-oxathiolanes with 2-mercaptoethanol catalyzed by TiCl₄-montmorillonitc Authors: Jin, Tong-Shou; Zhao, Rui-Qiao; Ma, Yen-Ran; Yang, Mi-Na; Guo, Jun-Jic; Li, Tong-Shuang Abstract: Formation of 1,3-oxathiolanes from aldehydes and ketones using 2-mercaptoethanol in the presence of TiCl₄-montmorillonite under mild reaction conditions in excellent yields is described. Chernoselective monothioacetalization of aldehyde in the presence of ketone can also he achieved in high yield. Page(s): 503-505

Microwave assisted convenient and facile regeneration of carbonyl compounds from semicarbazones, phenylhydrazones and tosylhydrazones using phosphoric acid in solvent-free conditions

2009-10-21T16:30:34Z

Title: Microwave assisted convenient and facile regeneration of carbonyl compounds from semicarbazones, phenylhydrazones and tosylhydrazones using phosphoric acid in solvent-free conditions Authors: Banerjee, Krishna; Mitra, Alok Kumar; Patra, Amarendra Abstract: Microwave irradiation of semicarbazones, phenylhydrazones and tosylhydrazones of carbonyl compounds with phosphoric acid under solvent-free conditions provides a fast, efficient and simple method for regeneration of carbonyls in excellent yields. Page(s): 537-539

NOPR Collection:

Cytotoxic ent-kaurane diterpenoids from Isodon racemosa (Hemsl) Hara

Synthesis of pyrazolines, isoxazolines and aminopyrimidines as biological potent agents

An efficient and chemoselective method for conversion of carbonyl compounds to 1,3-oxathiolanes with 2-mercaptoethanol catalyzed by TiCl4-montmorillonitc

Microwave assisted convenient and facile regeneration of carbonyl compounds from semicarbazones, phenylhydrazones and tosylhydrazones using phosphoric acid in solvent-free conditions

An efficient and chemoselective method for conversion of carbonyl compounds to 1,3-oxathiolanes with 2-mercaptoethanol catalyzed by TiCl₄-montmorillonitc