NOPR Collection:http://nopr.niscpr.res.in/handle/123456789/614042026-10-10T18:17:38Z2026-10-10T18:17:38ZSynthesis of Schiff bases of 2-amino benzo[d]thiazole from higher hetero aldehydes and ketones using Mo-Al2O3 composite-based organocatalystAnam, Koteswara RaoThirunarayanan, Ganesamoorthyhttp://nopr.niscpr.res.in/handle/123456789/614162023-02-21T10:33:55Z2023-02-01T00:00:00ZTitle: Synthesis of Schiff bases of 2-amino benzo[d]thiazole from higher hetero aldehydes and ketones using Mo-Al2O3 composite-based organocatalyst
Authors: Anam, Koteswara Rao; Thirunarayanan, Ganesamoorthy
Abstract: A new metal supported organo catalyst has been successfully employed to carry out the high yield Schiff’s base reaction
at ambient temperature. This methodology has the benefits of straightforward conditions, excellent yields, no work-up,
environmental benign process and reusable solid catalyst. The catalyst speeds up the Schiff base reaction with less time and
several Schiff bases have been synthesized and characterized with IR, 1H and 13C NMR techniques.
Page(s): 91-982023-02-01T00:00:00ZMicrowave-assisted solution phase synthesis of novel pyridine carboxamides in neat water and ADMET and protein-compounds interaction analysis and antibacterial activityBabu, VisagamoorthyDharman, PrabuBasha, K Anverhttp://nopr.niscpr.res.in/handle/123456789/614152023-02-21T10:29:01Z2023-02-01T00:00:00ZTitle: Microwave-assisted solution phase synthesis of novel pyridine carboxamides in neat water and ADMET and protein-compounds interaction analysis and antibacterial activity
Authors: Babu, Visagamoorthy; Dharman, Prabu; Basha, K Anver
Abstract: A range of novel 5-substituted-pyridine-2-carboxamides have been designed and synthesized by microwave-assisted
solution phase synthesis in neat water. Their structures have been confirmed by 1H NMR, 13C NMR and LCMS analysis.
The present work describes a simple, rapid, and efficient synthesis of compound 2a-2h in good yield under mild reaction
condition. Shorter reaction time and convenient workup make this methodology more practical. This protocol proceeds
smoothly and avoids the use of toxic organic solvents. ADMET analysis have been performed for all the synthesized
compounds and observed that all the eight compounds taken for the investigation have been shown to satisfy Lipinski's rule
of 5. The molecular interaction study is performed using the AutoDock software. All the 8 test compounds are found to have
higher binding affinity than the control compound chloramphenicol to the E. Coli DraE adhesion. In addition antibacterial
activities of all eight compounds have been determined.
Page(s): 99-1062023-02-01T00:00:00ZRu(II)/PEG-400: A green synthesis of indolyl-oxindoles and indolyl-cyclohexanedione hybrids as potential antimicrobial agentsWagh, Shaila SPatil, Arvind MKasralikar, Hanmant Mhttp://nopr.niscpr.res.in/handle/123456789/614142023-02-21T10:24:37Z2023-02-01T00:00:00ZTitle: Ru(II)/PEG-400: A green synthesis of indolyl-oxindoles and indolyl-cyclohexanedione hybrids as potential antimicrobial agents
Authors: Wagh, Shaila S; Patil, Arvind M; Kasralikar, Hanmant M
Abstract: A green and sustainable methodology has been successfully employed for the synthesis of 3-Indolyl-3-hydroxy
oxindoles and 3-indolyl-3-hydroxy-5,5-dimethylcyclohexane-1,3-dione derivatives using Ru(II)/PEG-400 as a homogeneous
recyclable catalytic system from substituted isatin with indole and dimedone. Short reaction time, simple extraction
procedure, substrate scope with high yield of the product, biodegradable solvent and recyclability of the catalyst without loss
of its activity enhances the efficiency of the proposed protocol. The synthesized compounds are studied for their
antimicrobial activity.
Page(s): 107-1142023-02-01T00:00:00ZSynthesis and bio-evaluation of novel acyl derivatives of karanjinEanti, AnjaneyuluKuncha, MadhusudanaArundha, AndeMisra, SunilVidavalur, SiddaiahRamakrishna, SistlaKanjilala, Sanjithttp://nopr.niscpr.res.in/handle/123456789/614132023-02-21T10:19:41Z2023-02-01T00:00:00ZTitle: Synthesis and bio-evaluation of novel acyl derivatives of karanjin
Authors: Eanti, Anjaneyulu; Kuncha, Madhusudana; Arundha, Ande; Misra, Sunil; Vidavalur, Siddaiah; Ramakrishna, Sistla; Kanjilala, Sanjit
Abstract: Different lipidic moieties such as 10-undecenoic, oleic, lipoic, caproic, caprylic and lauric acids have been acylated to
demethylated karanjin to prepare six lipoconjugated karanjin. All the derivatives have been evaluated for antimicrobial,
anticancer and antiinflammatory activities and compared with karanjin and its demethylated analog. Lipoconjugation does
not seem to improve the activity of karanjin against studied bacterial and fungal strains. However, karanjin, demethylated
karanjin and six lipoconjugated karanjin show moderate to good anticancer activity against prostate and breast cancer cell
lines. Mild antiinflammatory response has also been observed in case of karanjin and lipoic acid-conjugated karanjin.
Page(s): 115-1202023-02-01T00:00:00Z