NOPR Collection:http://nopr.niscpr.res.in/handle/123456789/628972026-10-09T09:57:53Z2026-10-09T09:57:53ZDesign, synthesis and antitubercular activity of pyrazole and benzo[d]imidazole clubbed dihydroimidazo[1,2-a]pyrimidinonesDesai, NisheethMonapara, JahnviJethawa, Aratibahttp://nopr.niscpr.res.in/handle/123456789/629092023-11-17T06:18:45Z2023-11-01T00:00:00ZTitle: Design, synthesis and antitubercular activity of pyrazole and benzo[d]imidazole clubbed dihydroimidazo[1,2-a]pyrimidinones
Authors: Desai, Nisheeth; Monapara, Jahnvi; Jethawa, Aratiba
Abstract: The discovery and development of new pharmaceutically active drugs by medicinal chemists is being impeded by the
emerging issue of antimicrobial resistance. It has triggered the urgent necessity for the generation of new medicinally active
compounds. In addition, novel dihydroimidazo[1,2-a]pyrimidinone containing clubbed pyrazole and benzo[d]imidazole
derivatives (5a-o) have been developed, synthesized, and tested for their antitubercular efficacy. IR, 1H and 13C NMR, and
mass spectroscopy are among the analytical methods used to establish structures of the novel compounds. Mycobacterium
TB H37Rv strain has been used in the antitubercular screening. The most effective derivatives (5c and 5h) against the tested
strain have MIC values of 50 μg/mL. The MIC values of the further derivatives 5a, 5b, 5e, 5f, 5g, 5i, and 5l ranged from
62.5 to 125 μg/mL.
Page(s): 1131-11402023-11-01T00:00:00ZDesign, synthesis, characterization and biological evaluation, of some novel (E)-6-(benzyloxy)-2-(4-bromobenzylidene)-7-methylbenzofuran-3(2H)-one derivativesPatel, Foram JPatel, Kinjal DAudichya, Vipul BPatel, Rashmikant Ahttp://nopr.niscpr.res.in/handle/123456789/629082023-11-17T06:17:10Z2023-11-01T00:00:00ZTitle: Design, synthesis, characterization and biological evaluation, of some novel (E)-6-(benzyloxy)-2-(4-bromobenzylidene)-7-methylbenzofuran-3(2H)-one derivatives
Authors: Patel, Foram J; Patel, Kinjal D; Audichya, Vipul B; Patel, Rashmikant A
Abstract: Synthesis of aurones and their derivatives have attracted considerable attention due to their significant biological effects investigated along with their corresponding chalcones against some bacterial as well as fungal strains. Title compound 6-(benzyloxy)-2-[(substitutedphenyl)methylidene]-7-methyl-1-benzofuran-3(2H)-one (2a-i) have been synthesized from 1-[4-benzyloxy-2-hydroxy-3-methyl phenyl]-3-(substituted phenyl)prop-2-en-1-one. The structural assignment of the compounds was based on elemental analysis and IR, 1H NMR, LC Mass, and 13C NMR spectral data. All the synthesized compounds have been screened for their antimicrobial activity to gram-positive and gram-negative bacterial strains and antifungal activity. The antimicrobial activities of the synthesized compounds have been compared with standard drugs like Gentamycin and K. Nystatin. Purity of synthesized compounds has been checked by TLC.
Page(s): 1141-11462023-11-01T00:00:00ZSynthesis of N-cinnamoyl dipeptide esters and investigation of their self-assembly leading to nanorods formationShete, SaurabhGavali, ManojRamana, M M VMaduskar, MandarKaranjule, NanabhauYadav, Dilip Kumarhttp://nopr.niscpr.res.in/handle/123456789/629072023-11-17T06:15:03Z2023-11-01T00:00:00ZTitle: Synthesis of N-cinnamoyl dipeptide esters and investigation of their self-assembly leading to nanorods formation
Authors: Shete, Saurabh; Gavali, Manoj; Ramana, M M V; Maduskar, Mandar; Karanjule, Nanabhau; Yadav, Dilip Kumar
Abstract: Synthesis of novel N-cinnamoyl dipeptide esters have been carried out under solution phase conditions. The synthesized compounds have been characterized by IR, NMR and mass spectrometry. These compounds readily self-assemble to form nanorods. Their morphology have been studied using SEM and TEM.
Page(s): 1147-11502023-11-01T00:00:00ZSynthesis, molecular docking and CNS activity of 5,5-diphenylimidazolidine- 2,4-dione derivativesVerma, ShwetaRani, Sonamhttp://nopr.niscpr.res.in/handle/123456789/629062023-11-17T06:12:35Z2023-11-01T00:00:00ZTitle: Synthesis, molecular docking and CNS activity of 5,5-diphenylimidazolidine- 2,4-dione derivatives
Authors: Verma, Shweta; Rani, Sonam
Abstract: The new Phenytoin derivatives have been synthesized, characterized, and compared for CNS activity. The synthesis was carried out in three steps. Firstly, the chloroacetylation of the 5,5-diphenyl hydantoin is carried out and then various substituted phenols are added into it and have been evaluated for anti-anxiety activity, muscle relaxant activity and anticonvulsant activity by using different models. The number of parameters have been optimized which reveal that the compound containing chloro group such as C3 and C6 show imperative potential when compared with the standard drug Diazepam. The newly synthesised compounds have the probability to be optimized further to engender new scaffolds to treat various CNS disorders.
Page(s): 1151-11612023-11-01T00:00:00Z