NOPR Collection:http://nopr.niscpr.res.in/handle/123456789/63122026-10-10T00:51:31Z2026-10-10T00:51:31ZModulation of serum cortisol by Substance P in albino rats: Evidence of a direct effect on adrenal glandPrasad, AnitaNaskar, RanuDubey, RakhiRaha, DipaliAhmed, M Firozhttp://nopr.niscpr.res.in/handle/123456789/63712009-11-03T16:30:36Z2006-02-01T00:00:00ZTitle: Modulation of serum cortisol by Substance P in albino rats: Evidence of a direct effect on adrenal gland
Authors: Prasad, Anita; Naskar, Ranu; Dubey, Rakhi; Raha, Dipali; Ahmed, M Firoz
Abstract: Effect of prolonged administration
of substance P on the plasma cortisol level in the albino rats has been
investigated. An inhibitory impact on intact individuals and a stimulatory
effect in pharmacologically annulled rats has been observed. It is concluded
that in normal conditions substance P presumably acts as a preventive agent for
any excess secretion of cortisol while during stress or disturbed HPA or RAS
conditions, it stimulates the secretion of cortisol. An intraglandular
modulatory role of substance P has been suggested.
Page(s): 163-1642006-02-01T00:00:00ZFormation of <i style="">ortho</i>-benzoquinone from sodium benzoate by <i style="">Pseudomonas mendocina</i> P<sub>2</sub>dParulekar, ChandaMavinkurve, Suneelahttp://nopr.niscpr.res.in/handle/123456789/63702009-11-04T16:30:31Z2006-02-01T00:00:00ZTitle: Formation of <i style="">ortho</i>-benzoquinone from sodium benzoate by <i style="">Pseudomonas mendocina</i> P<sub>2</sub>d
Authors: Parulekar, Chanda; Mavinkurve, Suneela
Abstract: <i style="">Pseudomonas mendocina</i> P<sub>2</sub>d grew in sodium benzoate at as
high as 1% concentration and formed a quinonoid compound, identified as <i style="">ortho</i>-benzoquinone, that rendered the
medium orange to wine-red in colour. The quinone was not metabilised further by
the organism. Sodium benzoate was converted to catechol, which was a central
metabolite forming <i style="">ortho-</i>benzoquinone
and 2- hydroxymuconic semialdehyde (2-HMS) via.
<i style="">meta</i>ring cleavage pathway.
Page(s): 157-1622006-02-01T00:00:00ZResponse surface optimization of effective medium constituents for the production of alkaline protease from a newly isolated strain of <i style="">Pseudomonas</i> <i style="">aeruginosa</i>Khan, SaifMisra, A KTripathi, C K MMishra, B NBihari, Vinodhttp://nopr.niscpr.res.in/handle/123456789/63692009-11-05T16:30:36Z2006-02-01T00:00:00ZTitle: Response surface optimization of effective medium constituents for the production of alkaline protease from a newly isolated strain of <i style="">Pseudomonas</i> <i style="">aeruginosa</i>
Authors: Khan, Saif; Misra, A K; Tripathi, C K M; Mishra, B N; Bihari, Vinod
Abstract: Optimization of the fermentation
medium for maximum alkaline protease production was carried out with a new
strain of <i style="">Pseudomonas aeruginosa (B-2)</i>.
Replacing the protein source/inducer (albumin in place of casein) brought about
significant increase in yield after 48 hr of inoculation. Three most effective
medium constituents identified by initial screening method of Plackett-Burman
were albumin, (NH<sub>4</sub>)<sub>2</sub>SO<sub>4</sub> and glucose. Central
Composite Design (CCD) and Response Surface Methodology (RSM) were used in the
design of the experiment and in the analysis of the results. Optimum levels of
the effective medium constituents were albumin (6.586%); (NH<sub>4</sub>)<sub>2</sub>SO<sub>4</sub>,<sub>
</sub>0.164%; and glucose, 6.72%. The alkaline protease production increased
from 533460 to 793492 Ul<sup>-1</sup>.
Page(s): 151-1562006-02-01T00:00:00ZIsolation and characterization of a new osmotolerant, non-virulent <i style="">Klebsiella pneumoniae </i>strain SAP for biosynthesis of succinic acidThakker, ChandreshBurhanpurwala, ZainabRastogi, GurdeepShouche, YogeshRanade, Diliphttp://nopr.niscpr.res.in/handle/123456789/63682009-11-06T16:30:36Z2006-02-01T00:00:00ZTitle: Isolation and characterization of a new osmotolerant, non-virulent <i style="">Klebsiella pneumoniae </i>strain SAP for biosynthesis of succinic acid
Authors: Thakker, Chandresh; Burhanpurwala, Zainab; Rastogi, Gurdeep; Shouche, Yogesh; Ranade, Dilip
Abstract: In the present study, isolation
of anaerobic bacteria from 24 different eco-niches was carried out. A total
number of 300 bacterial isolates, including 230 obligate and 70 facultative
anaerobes were obtained using anaerobic techniques. All the isolates were
initially screened for succinic acid production by Fluorescein test and TLC
method. During screening, 10 isolates found to produce succinic acid were
further examined by HPLC and then finally confirmed for succinic acid by LC-MS
analysis. Amongst 10 isolates, isolate SAP, a facultative anaerobe isolated
from buffalo rumen fluid, showed maximum yield of 2.1 g/l of succinic acid from
10 g of glucose in 24 hr under anaerobic condition. This isolate was identified
as <i style="">Klebsiella pneumoniae </i>strain SAP
by 16S rDNA sequence and signature sequence analysis. Mouse lethality test for
the strain SAP showed LD<sub>50</sub> value of 3.3 × 10<sup>8</sup> CFU/ml,
which shows non-virulent nature of the strain. This strain may become a
candidate strain for succinic acid production because of its osmotolerant
nature and higher succinate:acetate ratio.
Page(s): 142-1502006-02-01T00:00:00Z