http://nopr.niscpr.res.in/handle/123456789/63363 2026-10-13T04:10:17Z 2026-10-13T04:10:17Z Bahaj, Marwan Salem Maki, Marwan Abdelmahmoud Abdelkarim Rao, KRS Sambasiva Kumar, & Palanirajan Vijayaraj http://nopr.niscpr.res.in/handle/123456789/63368 2024-02-22T05:53:09Z 2024-02-01T00:00:00Z

Title: Progressive exploration on the influence of natural polymers and emerging biomaterials in advanced wound care strategies Authors: Bahaj, Marwan Salem; Maki, Marwan Abdelmahmoud Abdelkarim; Rao, KRS Sambasiva; Kumar, & Palanirajan Vijayaraj Abstract: The field of wound care has continuously improved by using techniques and materials to promote healing and minimize complications. A key factor, in this progress is the utilization of polymers and cutting-edge biomaterials. In this examination, we explore the role and impact of these substances on wound management practices. We delve into the characteristics of polymers like chitosan, alginate, and collagen which are derived from living organisms and offer advantages in terms of compatibility with the body's ability to break down naturally and suitability for various wound applications. Additionally, we investigate emerging biomaterials such as nanofibers, hydrogels, and bioactive glass highlighting their potential for delivering drugs in a controlled manner and influencing the healing environment within wounds. The incorporation of these materials into wound care has shown results including healing processes, reduced formation of scar tissue, and improved infection control. Despite these advancements, our review acknowledges existing challenges such as expanding production capacity standardizing products across the industry and overcoming obstacles in implementation. The aim of this paper is to provide an overview of the state of the art in wound care strategies while also offering insights into potential solutions and future directions, for research and application. Page(s): 127-144

2024-02-01T00:00:00Z Ristić, Tijana Luković, Jovan Nikolić, Ivana Anđelković, Marija Pirković, Marijana Stanojević Canović, Petar Muškinja, Jovana Popović, Suzana Mitrović, Marina http://nopr.niscpr.res.in/handle/123456789/63367 2024-02-21T06:58:44Z 2024-02-01T00:00:00Z

Title: Cytotoxic and apoptotic effect of chalcone 5 on mouse colon cancer cells CT-26 Authors: Ristić, Tijana; Luković, Jovan; Nikolić, Ivana; Anđelković, Marija; Pirković, Marijana Stanojević; Canović, Petar; Muškinja, Jovana; Popović, Suzana; Mitrović, Marina Abstract: According to World Health Organization data, various forms of cancer cause around 10 million deaths each year. Nearly 2 million new colon and rectal cancer cases were detected in 2020, making it the second greatest cause of cancer death. Aside from the harmful effects of various chemotherapeutic agents, a special difficulty for treating and eradicating these diseases is tumor resistance to existing anticancer medications and undesired side effects of chemotherapy against healthy cells and tissue. Chalcones are precursors for the synthesis of flavonoids and other compounds with a heterocyclic structure. The biological activities of this category of chemicals include antibacterial, anti-inflammatory, anticancer, antidiabetic, and antiproliferative properties. In the current study, we therefore examined the antitumor and apoptotic effects of chalcone 5 on mouse colon carcinoma cell line CT-26. Chalcone 5 caused the inner mitochondrial apoptotic pathway to be triggered in CT-26 cells by inducing apoptosis, disrupting the potential of the mitochondrial membrane and causing the release of cytochrome c into the cytosol. Based on results obtained in this study, chalcone 5 may be recommended as a potential promising anti-cancer candidate for future in vivo research studies utilizing experimental animals. Page(s): 145-152

2024-02-01T00:00:00Z Patel, Nidhi Y Parmar, Fenil Patel, Jay Dighe, Harshali Raval, Shivani Yagnik Raval, Vikram H http://nopr.niscpr.res.in/handle/123456789/63366 2024-02-21T06:56:14Z 2024-02-01T00:00:00Z

Title: Optimization studies of L-glutaminase production from Halomonas hydrothermalis B-15-9-2 isolated along Gujarat coasts Authors: Patel, Nidhi Y; Parmar, Fenil; Patel, Jay; Dighe, Harshali; Raval, Shivani Yagnik; Raval, Vikram H Abstract: L-glutaminase (EC 3.5.1.2) is an enzyme grouped under amidohydrolase and a member of serine-dependent β-lactamases & penicillin-binding proteins. The present study focuses on increasing the yield of L-glutaminase from marine bacteria isolated from coastal regions of Gujarat. Using enrichment culture technique marine samples were enriched and physicochemical analysis was done. A total of 12 bacteria isolated from Gujarat coasts were screened for L-glutaminase biosynthesis. Out of 12, most potent one isolate B-15-9-2 was selected for cultural, biochemical, and molecular identification by 16S rRNA analysis, which reveals the nearest homolog is Halomonas hydrothermalis with 99.87% similarity. To the best of our knowledge this is the first report of Halomonas hydrothermalis as L-glutaminase producer from Gujarat coasts. Further study deals with the optimization of medium components for higher yield of L-glutaminase by one variable at a time & response surface methodology. There was a significant increase in the L-glutaminase activity about 3.4-fold from 29 ± 0.8 U/mL to 98.95 ± 0.5 U/mL upon media optimization via statistical method. Page(s): 153-165

2024-02-01T00:00:00Z Yingying, Deng Shicheng, Hu Yingchun, Jiao http://nopr.niscpr.res.in/handle/123456789/63365 2024-02-22T06:16:41Z 2024-02-01T00:00:00Z

Title: Physiological evidence for the relationship between unsaturated fatty acid and cell permeability in extracellular polysaccharide synthesis and secretion Agaricus bitorquis (Quél.) Sacc. Chaidam Authors: Yingying, Deng; Shicheng, Hu; Yingchun, Jiao Abstract: In this study, the regulatory mechanism of exopolysaccharides from Agaricus bitorguis (Quél.) Sacc. Chaidam was investigated using Lycium ruthenicum Murr. Anthocyanins during cell growth and polysaccharide synthesis. The anthocyanin composition of Lycium ruthenicum Murr. was investigated by UHPLC-HRMS method, the anthocyanin derivatives of petunia ligand and proanthocyanidins, which was the main anthocyanin substance, and the results showed that the effect of LRA extract was better than that of the single component standard. Based on metabolomics, we have identified 2522 metabolites, including linoleic acid, α-linolenic acid and oleic acid were significantly up-regulated, and stearic acid, 16-hydroxypalmitic acid and 10-undecylenic acid were significantly down-regulated compared with the blank group. According to transcriptomics results and KEGG enrichment analysis, differential genes are mainly distributed in pathways such as unsaturated fatty acid metabolism and α-linolenic acid metabolism. By up-regulating stearyl CoA desaturase and acyl CoA oxidase, the content of α-linolenic acid, linoleic acid, and oleic acid increased the conversion of saturated fatty acids to unsaturated fatty acids, improved the fluidity of cell membranes, thereby enhancing the growth of ABSC mycelium. Page(s): 166-181

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