NOPR Collection: Special Issue on Green/Sustainable Chemistry

3,5-Bis(arylmethylene)-4-piperidone derivatives as novel anticancer agents

2016-07-20T06:45:44Z

Title: 3,5-Bis(arylmethylene)-4-piperidone derivatives as novel anticancer agents Authors: Jha, Amitabh; Duffield, Katherine M Abstract: 3,5-Bis(arylmethylene)-4-piperidone derivatives have emerged as novel clusters of cytotoxic agents. The focus of the current research has been to tine tune the biological activity of these compounds by rational alteration of substituents on this pharmacophore to increase potency and selectivity. These compounds arc presumed to bc devoid of gcnctoxicity and act by selective thiolation of proteins. Anticancer behavior of nine clusters of 3,5-bis(arylmethylene)-4-piperidone derivatives have been reviewed here with emphasis on their chemistry, cytoxicity and quantitative structure-activity relationship studies. Page(s): 2313-2320

Within the portals of green chemistry: Green strategies to manage curriculum induced hazards in chemistry laboratories

2016-07-20T06:45:39Z

Title: Within the portals of green chemistry: Green strategies to manage curriculum induced hazards in chemistry laboratories Authors: Bhanumati, S; deep, Harsh Abstract: There are several chemistry reactions prescribed in the undergraduate syllabi that nearly half the pupil population dread performing (chemophobia), To feel safe and comfortable both physically and psychologically, while working in the laboratories is a legitimate right of every student. The tutors and the instructors share this responsibility. Some green procedures arc being suggested here to establish a doer-friendly atmosphere in the laboratories. The work entails (i) working in meso/micro scale quantities (ii) offmering an alternative chemical/procedure/route for achieving the same results. Two in one economically viable volumetric titrations are proposed which focus on better learning in lesser time. Using the interplay of physical and chemical principles, desired results can be achieved for the preparation of many organic derivatives and often with better yield and purity. Some classical procedures are modified in a green way. Typical organic derivatives have been prepared with minimum energy requirements at ambient temperature avoiding the use of auxiliary substances and avoiding multiple steps in accordance with Green Principles 5, 6 and 8. Two in one derivatives are also prepared for convenience, better quality (even unnecessitating recrystallization) and of-course ill improved yields. Atom economy is critically handled for practical purpose. Page(s): 2353-2360

Grignard reagent and Green Chemistry: Mechanistic studies to understand the molecular origins of selectivity in the formation of RMgX

2016-07-20T06:04:04Z

Title: Grignard reagent and Green Chemistry: Mechanistic studies to understand the molecular origins of selectivity in the formation of RMgX Authors: Hazimeh, Hassan; Mattalia, Jean-Marc; Attolini, Mireille; Bodineau, Nicolas; Marchi-Delapierre, Kishan Handoo Caroline Abstract: Controlling selectivity is one or the important keywords in the development of Green Chemistry. The mechanistic study of the formation of RMgX with the aim of understanding at which step(s) the selectivity is settled shows that there is room for basic research in a field too often considered as the simple development of new recipes. One of the most widely used reactions in synthetic studies still offers fascinating conundrums when one tries to answer the apparently simple question: at which step(s) docs the formation of by-products coexisting with RMgX occur? Here the illustration of this statement is given by studying the patterns of reactivity of aliphatic and aromatic radical clock halides toward magnesium or potassium. The importance of using the concepts developed by electrochemists to rationalize the selectivity observed at cathodes or anodes for understanding selectivity observed in the reactive dissolution of metals is stressed. Page(s): 2270-2280

Microwave effect in organic reactions

2009-11-20T16:30:37Z

Title: Microwave effect in organic reactions Authors: Dewan, Sharwan K Abstract: Based upon extensive analysis of the organic reactions reported in the literature, a qualitative method for the prediction of the presence or absence of specific microwave effect in organic reactions has been advanced. The specific microwave effect will be observed only if all the reactants are polar in nature. It is unlikely to be observed if the reactions involve a non-polar reactant. Page(s): 2337-2340