NOPR Collection:http://nopr.niscpr.res.in/handle/123456789/653842026-10-10T19:11:36Z2026-10-10T19:11:36ZChitosan augmented activated charcoal for adsorption of reactive red 21 dye from solution phaseM Nandanwar, PM Jugade, Rhttp://nopr.niscpr.res.in/handle/123456789/654042025-02-20T06:58:13Z2025-02-01T00:00:00ZTitle: Chitosan augmented activated charcoal for adsorption of reactive red 21 dye from solution phase
Authors: M Nandanwar, P; M Jugade, R
Abstract: Polymers have been proven to be an interesting class of adsorbents applied in water treatment. Biopolymers are of
special interest due to their unique properties such as biocompatibility, biodegradability and reusability. This work reports a
composite formed by a chitosan biopolymer and activated charcoal using sodium citrate as a crosslinking agent. The
chitosan–citrate-activated charcoal composite (CCA) has been characterized using FT–IR, SEM, EDAX, XRD, TGA–DTA
and BET surface area analysis. The material has been found to be microporous in nature with a surface area of 165.83 m2/g
that has led to high adsorption capacities toward the targeted pollutant. In aqueous phase, the dye adsorption studies have
been carried out with reactive 21 (R-21) dye. Under optimum solution conditions, maximum Reactive Red (R-21) dye
removal capacity has been found to be 40.12 mg g−1. Intrinsic microporosity of CCA results in an enhanced capture capacity
for Reactive Red (R-21) dye. Material sustainability studies have been carried out to evaluate various sustainability
parameters.
Page(s): 127-1362025-02-01T00:00:00ZSynthesis of novel pyrido[2,3-d]pyrimidine derivatives with pharmacological propertiesT Tandel, HemanshuKayastha, PriyaB Mistry, Bhargavihttp://nopr.niscpr.res.in/handle/123456789/654032025-02-20T06:56:53Z2025-02-01T00:00:00ZTitle: Synthesis of novel pyrido[2,3-d]pyrimidine derivatives with pharmacological properties
Authors: T Tandel, Hemanshu; Kayastha, Priya; B Mistry, Bhargavi
Abstract: In search for new anti-microbial and anti-mycobacterial agents with novel mechanism of action and enhanced biological
profile, a combinatorial library of Schiff bases (7a-e), 2,3-disubstituted-4-thiazolidinone (8a-e) and 2,3-disubstituted-5-
methyl-4-thiazolidinone (9a-e) derivatives have been synthesized as new pharmacophores under standard Vilsmeier-Haack
reaction conditions. The structures of all the newly synthesised compounds have been confirmed from their FT-IR, 1H and
13C NMR, mass spectral as well as elemental analysis data. All the newly synthesized compounds have been screened for
non-automated in vitro antimicrobial and anti-mycobacterial activity against selected pathogens. Some of the newly
synthesized compounds exhibit excellent antimicrobial activity and found to be the most proficient members of the series
compared to standard drugs and hold promise as future drugs.
Page(s): 137-1472025-02-01T00:00:00ZStudies directed towards synthesis of leprostatic agent desoxyfructoserotoninReddy Gopireddya, SreenivasuluBannoth Chandrasekhar, KothapalliL N Ranganath, Prathapagirihttp://nopr.niscpr.res.in/handle/123456789/654022025-02-20T06:54:44Z2025-02-01T00:00:00ZTitle: Studies directed towards synthesis of leprostatic agent desoxyfructoserotonin
Authors: Reddy Gopireddya, Sreenivasulu; Bannoth Chandrasekhar, Kothapalli; L N Ranganath, Prathapagiri
Abstract: Leprosy is an infectious chronic disease and a neglected tropical disease induced by Mycobacterium leprae, and mainly
affects the skin, peripheral nerves, upper respiratory mucosa and eyes. The prolonged physical deformities associated with
leprosy get progressively worse with delayed diagnosis and increasing age. In this paper we report synthesis of
Desoxyfructoserotonin which is a leprostatic agent, using 5-methoxy indole and the desired chiral centres have been
incorporated using naturally obtained sugar moiety (D)-mannitol employing Vilsmeier-Haack reaction and Henry reactions.
Page(s): 148-1532025-02-01T00:00:00Z2,5-Diamino-1,4-benzoquinones: Promising candidates against HT-29 human colorectal cancer cell line and as HSP90 inhibitorsA, Ashahttp://nopr.niscpr.res.in/handle/123456789/654012025-02-20T06:34:28Z2025-02-01T00:00:00ZTitle: 2,5-Diamino-1,4-benzoquinones: Promising candidates against HT-29 human colorectal cancer cell line and as HSP90 inhibitors
Authors: A, Asha
Abstract: Herein is reported the synthesis of seven 2,5-diamino-1,4-benzoquinones to act as potent anti-cancer agents against
HT-29 human colorectal adenocarcinoma cell line via MTT assay, fluorescence microscopy and flow cytometric assays.
All the aminobenzoquinones show promising activity and 2,5-dibenzylamino-1,4-benzoquinone exhibits best results
(IC50 12.5 μg/mL). Flouresence microscopic and cell cycle analysis have been carried out to study the pathway of their
activity. Molecular docking analysis using Schrodinger software have been carried out to study the ability of these
compounds to act as HSP90 inhibitors.
Page(s): 154-1642025-02-01T00:00:00Z