NOPR Collection:http://nopr.niscpr.res.in/handle/123456789/663552026-10-10T16:38:15Z2026-10-10T16:38:15ZSynthesis, spectral and biological evaluation of in vitro antimicrobial activity and molecular docking studies of Schiff base ligand 1,2-cyclohexadiene/o-vanillin and its transition metal complexesPriya, JManimalathi, SMadheswari, Dhttp://nopr.niscpr.res.in/handle/123456789/663652025-08-25T09:54:47Z2025-08-01T00:00:00ZTitle: Synthesis, spectral and biological evaluation of in vitro antimicrobial activity and molecular docking studies of Schiff base ligand 1,2-cyclohexadiene/o-vanillin and its transition metal complexes
Authors: Priya, J; Manimalathi, S; Madheswari, D
Abstract: Exploring application of cost-effective transition metal-based drugs with high pharmaceutical properties has led to the
progression of Schiff-base centred medicinal chemistry. Following this line, herein a series of new class of transition metal
complexes Ni(II), Cd(II), Mn (II) and Zn(II) have been synthesized using a Schiff base ligand derived from 2 moles of
o-vanillin and 1 mole of 1,2-cyclohexanediamine. The elemental analysis, conductivity, 1H NMR, UV-Vis, IR spectra and
TGA studies have been used to characterize the as-synthesized ligand together with associated metal complexes.
Additionally, testing the antimicrobial properties against Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria
establishes a higher inhibiting efficiency and high-points the role of the compounds in stronger antibiotic use action. As a
result, the current study acknowledges the potential of the new Schiff-base derived complexes as prescription medication.
Page(s): 761-7672025-08-01T00:00:00ZDesign and synthesis of novel triazole based small molecules mimicking HDACi as new modular drugs candidate against Omicron and future variants of Sars-Cov-2Pakrashy, SouravPaul, SandipMisra, SouravSutradhar, DiyaKumar Maurya, PawanMajhi, Anjoyhttp://nopr.niscpr.res.in/handle/123456789/663642025-08-25T09:52:54Z2025-08-01T00:00:00ZTitle: Design and synthesis of novel triazole based small molecules mimicking HDACi as new modular drugs candidate against Omicron and future variants of Sars-Cov-2
Authors: Pakrashy, Sourav; Paul, Sandip; Misra, Sourav; Sutradhar, Diya; Kumar Maurya, Pawan; Majhi, Anjoy
Abstract: Due to the multi-modal nature of coivd 19 infection, dual target inhibition simultaneously by a solo molecule can be
helpful and a possible operative method against coivd 19 and its variants. Histone-deacetylase (HDAC) has been extensively
examined as a useful type of anti-cancer molecule due to its dynamic part in numerous biotic biological progressions, for
example cell-proliferation, cell-metastasis, and cell-apoptosis. Numerous HDACi (HDAC-inhibitors) like vorinostat,
panobinostat are clinically permitted and their direct usage in covid 19 patients may be helpful. Therefore, in this work, we
report five novel small molecules mimicking HDACi with a double targeting capability of HDAC and covid 19 causing
proteins Mpro and its variant omicron S-protein. The strategy that has been employed is the use of simple click reaction to
develop these compounds along with their in silico study as inhibitors of covid 19 infection.
Page(s): 768-7742025-08-01T00:00:00ZExploring potential electrical and LPG sensing properties of polyaniline-Co3O4 nanocompositeMahadevaB, ManjunathaGogi, ShrutiN Birge, VaishaliT Vijaykumar, BLagashetty, ArunkumarKalyane, Sangshettyhttp://nopr.niscpr.res.in/handle/123456789/663632025-08-25T09:50:32Z2025-08-01T00:00:00ZTitle: Exploring potential electrical and LPG sensing properties of polyaniline-Co3O4 nanocomposite
Authors: Mahadeva; B, Manjunatha; Gogi, Shruti; N Birge, Vaishali; T Vijaykumar, B; Lagashetty, Arunkumar; Kalyane, Sangshetty
Abstract: Polymer nanocomposites are an important class of materials in which recent researches are reported extensively due to
their vast range of applications. Various synthetic methods are available in the literature and much importance is given to
scalable processing techniques for sensing applications. The composite of polyaniline (Pn) doped with nanosized cobalt
oxide (Pn/Co3O4) has been synthesized using a chemical oxidative polymerization of aniline in presence of various weight
percentage of Co3O4. The structural and morphological characterizations of the prepared samples have been examined using
X-ray diffraction (XRD) and scanning electron microscopy (SEM) tool, respectively. AC conductivity of the prepared
samples has been measured using the impedance technique within a frequency range of 10 KHz to 1 MHz at room
temperature. Additionally, the DC electrical transport property of the composites have been experimented within a
temperature range of 30-200°C. It is observed that the incorporation of nanosized Co3O4 into the PA matrix has an impact
on the AC electrical properties of the samples. The variation in electrical resistance of both Pn and Pn/Co3O4 composites
has been noted when exposed to 1000 ppm concentration of LPG gas. Both samples exhibit a quick resistance change on
exposure to LPG gas with the Pn/Co3O4 composite demonstrating higher sensitivity and suitability for LPG sensing
compared to Pn.
Page(s): 775-7802025-08-01T00:00:00ZSynthesis and characterization of nanosized zinc stannate for thermal applicationLagashetty, ArunkumarS, SindhuM, VivekH, VeenaSanchi, GururajK Ganiger, Sangappahttp://nopr.niscpr.res.in/handle/123456789/663622025-08-25T09:47:59Z2025-08-01T00:00:00ZTitle: Synthesis and characterization of nanosized zinc stannate for thermal application
Authors: Lagashetty, Arunkumar; S, Sindhu; M, Vivek; H, Veena; Sanchi, Gururaj; K Ganiger, Sangappa
Abstract: Nano sized bimetallic oxide materials have been extensively studied worldwide because of their unique properties and
applications. One of the methods studied is the facial approach to preparing well dispersed nanocrystals of zinc stanate
(ZnSnO3) using Zn and Sn oxalate as precursors. Self-propagating high temperature synthesis method has been adopted
using polymer fuel. Combustion processed ZnSnO3 nanomaterials have been confirmed by various characterization tools.
X-ray diffraction (XRD) tool is used to study the structure of the prepared bimetallic oxide nanomaterials sample.
Morphological study of prepared sample is carried out by scanning electron microscope (SEM) analysis. Bonding nature of
the sample has been studied by Fourier transform infrared (FT-IR) tool and presence of the Zn and Sn in the prepared
sample has been identified by EDX analysis respectively. Absorption study of the prepared sample has been characterized
by UV-Vis spectroscopy. Thermal behaviour of the bimetallic oxide sample has been analyzed by thermo gravimetric
analysis (TGA), Raman spectroscopic (RS) study has been undertaken to view its structural organization. Dynamic light
scattering (DLS) study has been implemented to know the size of the sample. Cyclic voltammetry (CV) study has also been
used to know the electrolytic behaviour of the zinc stannate sample.
Page(s): 781-7862025-08-01T00:00:00Z