NOPR Collection:http://nopr.niscpr.res.in/handle/123456789/664802026-10-10T05:14:00Z2026-10-10T05:14:00ZSynthesis, characterization and antimicrobial activity of pyrazole derivativesAnusha Rechel, PolepakaJyothi, Sunkarihttp://nopr.niscpr.res.in/handle/123456789/665122025-09-30T06:21:23Z2025-09-01T00:00:00ZTitle: Synthesis, characterization and antimicrobial activity of pyrazole derivatives
Authors: Anusha Rechel, Polepaka; Jyothi, Sunkari
Abstract: This study synthesized pyrazole derivatives from pyrazoline and evaluated them for antibacterial activity. From benzofuran-
5-carbaldehyde and 1-(1,2,3,4-thiatriazol-5-yl)hydrazine, compound 1 is formed under reflux. Then DMF and POCl3 is added at
70°C for 5 h to the compound 1 to get compound 2. To a mixture of compound 2, acetophenone in ethanol and KOH is added
and stirred under reflux for 6 h to get compound 3. From the compound 3, different pyrazole derivatives have been synthesized.
All the desired compounds have been successfully synthesized and characterized by 1H and 13C NMR and LCMS. The
antimicrobial activity has been tested using a serial dilution approach against several Gram-positive and Gram-negative
bacteria. Compounds 1, 3, 5, 6, 8 and 9 show greater antimicrobial activity against several Gram-positive and Gram-negative
bacteria.
Page(s): 859-8632025-09-01T00:00:00ZInteraction between cationic and anionic surfactant using ultrasonic, physical and adiabatic parametersGupta, AdityaSaxena, InduMishra, DivyanshiYadav, Preetihttp://nopr.niscpr.res.in/handle/123456789/665112025-09-30T06:18:52Z2025-09-01T00:00:00ZTitle: Interaction between cationic and anionic surfactant using ultrasonic, physical and adiabatic parameters
Authors: Gupta, Aditya; Saxena, Indu; Mishra, Divyanshi; Yadav, Preeti
Abstract: Surfactants are organic amphiphilic molecules having hydrophilic and hydrophobic parts in the same molecule. The
relative densities, relative viscosities, specific conductance and ultrasonic velocity of sound of binary solutions of SDSCTAB
in water, formed in different mole fraction ratios, have been measured at 298 K and 308 K. From these data, the
physical parameters such as adiabatic compressibility (βad), intermolecular free length (Lf), acoustic impedance (Z),
relaxation time (τ) and molar free volume (Vf) have been evaluated using standard relations. The results are thus interpreted
in terms of molecular interactions between cationic and anionic surfactants. Investigated value of physical properties thus
defines that the molecular interaction is feasible and associative in nature and the determined acoustical and adiabatic
parameters supports that nature.
Page(s): 864-8702025-09-01T00:00:00ZNew Schiff base and potent antimalarial, antioxidant, antidiabetic ternary complexesRagole, VikasWankhede, DnyaneshwarBiradar, YogeshDeshmukh, PradeepGayakwad, SonajiButle, Santoshhttp://nopr.niscpr.res.in/handle/123456789/665102025-09-30T06:14:29Z2025-09-01T00:00:00ZTitle: New Schiff base and potent antimalarial, antioxidant, antidiabetic ternary complexes
Authors: Ragole, Vikas; Wankhede, Dnyaneshwar; Biradar, Yogesh; Deshmukh, Pradeep; Gayakwad, Sonaji; Butle, Santosh
Abstract: Potent antimalarial, antioxidant and antidiabetic ternary complexes have been obtained by RT reaction of Fe(III), Co(II),
Ni(II), Cu(II) and Zn(II) chlorides with new Schiff base (E)-2-((benzo[d]thiazol-2-ylimino) methyl)-4-nitrophenol (S3) and
8-hydroxyquinoline (8-HQ) in equimolar amounts. The SB (S3) is derived by reacting 2-hydroxy-5-nitrobenzaldehyde with
2-aminobenzothiazole using catalytic glacial acetic acid in an ethanolic medium. The compounds have been structurally
analysed using elemental analysis, IR, electronic spectra, TGA-DTA and powder XRD (PXRD) analysis, magnetic and molar
conductance measurements. All compounds have been screened for antimicrobial, antidiabetic, antioxidant, antimalarial and
anticancer activities, and exhibited future potential for use against these. Molecular docking studies of all the ternary complexes
have been conducted against multiple receptors viz., glucose oxidase, endonuclease, D-alanine ligase, oxidoreductase inhibitor,
hydrolase and squalene epoxidase. The obtained results have been assessed in terms of binding affinities.
Page(s): 871-8802025-09-01T00:00:00ZSynthesis and physicochemical analysis of bimetalphthaltocyanine pigment based on bivalent metalsF Dzh, MirzaevaKh Kh, TuraevI A, UmbarovA T, DzhalilovJ B, FayzievA K, Nomozovhttp://nopr.niscpr.res.in/handle/123456789/665092025-09-30T06:10:40Z2025-09-01T00:00:00ZTitle: Synthesis and physicochemical analysis of bimetalphthaltocyanine pigment based on bivalent metals
Authors: F Dzh, Mirzaeva; Kh Kh, Turaev; I A, Umbarov; A T, Dzhalilov; J B, Fayziev; A K, Nomozov
Abstract: In this paper, the research on the synthesis of magnesium-zinc-phthalocyanine pigment has been carried out. It has been
synthesized based on phthalic anhydride, urea, zinc acetate, and magnesium acetate. The molar ratio of the initial substances
is taken in the ratio of 1:4:3, and it has been synthesized with a yield of 89.5% and the reaction carried out at 225°C. The
structure of this obtained pigment has been analyzed by IR spectral analysis. Based on magnesium and zinc phthalocyanine
structures, it is found that the formation of phthalocyanine rings gives a peak in the region of 744.52-792.74 cm–1, while the
phenyl rings give a peak in the region of 975.98 cm–1. Its thermal stability has been measured by thermogravimetric
analysis, SEM (scanning electron microscope), EDS, and elemental analysis. According to the results of the analysis, it is
confirmed that magnesium-zinc phthalocyanine has been synthesized by forming phthalocyanine rings.
Page(s): 881-8872025-09-01T00:00:00Z