NOPR Collection:http://nopr.niscpr.res.in/handle/123456789/669852026-10-10T22:20:36Z2026-10-10T22:20:36ZSynthesis of α-hydroxy, β-bromo-exo-dicyclopentadiene-1-one: A new building block for cyclopentanoidsKotha, SambasivaraoReddy Keesari, Ramakrishnahttp://nopr.niscpr.res.in/handle/123456789/669922025-12-24T05:41:29Z2025-12-01T00:00:00ZTitle: Synthesis of α-hydroxy, β-bromo-exo-dicyclopentadiene-1-one: A new building block for cyclopentanoids
Authors: Kotha, Sambasivarao; Reddy Keesari, Ramakrishna
Abstract: Herein, we described a simple synthetic strategy for the preparation of α-hydroxy, β-bromo-exo-dicyclopentadiene-1-one
by following a three-step sequence. The synthetic strategy relies on operationally simple reactions and high yielding steps.
The newly synthesized compounds have been characterized by NMR. As the disclosed compound α-hydroxy, β-bromo-exodicyclopentadiene-
1-one is highly functionalized but structurally similar to exo-dicyclopentadiene-1-one and it can be used a
key building block for expanding the chemical space of cyclopentanoid derivatives.
Page(s): 1127-11322025-12-01T00:00:00ZLewis acid-promoted synthesis of 3-tosylisoindolinone from 3-hydroxyisoindolinone: Access to complex furopyrroloisoindoledioneDas, MalayKumar, VirendraJyoti Arandhara, PallavBiswas, SubhamoyK Saikia, Anilhttp://nopr.niscpr.res.in/handle/123456789/669912025-12-24T05:38:52Z2025-12-01T00:00:00ZTitle: Lewis acid-promoted synthesis of 3-tosylisoindolinone from 3-hydroxyisoindolinone: Access to complex furopyrroloisoindoledione
Authors: Das, Malay; Kumar, Virendra; Jyoti Arandhara, Pallav; Biswas, Subhamoy; K Saikia, Anil
Abstract: An efficient methodology has been developed for the synthesis of sulfur-functionalized isoindolone scaffold from
hydroxyisoindolinone via N-acyliminium ion intermediate using TosMIC and Lewis acid in good to excellent yields. The
strategy features mild reaction conditions, broad substrate scope and metal-free reaction method. The protocol has been
extended for the synthesis of complex furopyrroloisoindoledione derivatives.
Page(s): 1133-11432025-12-01T00:00:00ZAntituberculosis activity of α-aminoacyl amide derivativesB Makane, VitthalU Sinde, AkashAngayarkanni, BMalik, PradipChopra, Sidharthhttp://nopr.niscpr.res.in/handle/123456789/669902025-12-24T05:35:42Z2025-01-01T00:00:00ZTitle: Antituberculosis activity of α-aminoacyl amide derivatives
Authors: B Makane, Vitthal; U Sinde, Akash; Angayarkanni, B; Malik, Pradip; Chopra, Sidharth
Abstract: The preparation and evaluation of α-aminoacyl amide derivatives against M. tuberculosis H37Rv is reported. The
systematic modifications of hit compounds have been carried out. Compounds 19b and 19c are identified as potent and
selective inhibitors of M. tuberculosis H37Rv with MIC 2.5 μM and 2.6 μM, respectively. Compounds 19b and 19c hold a
promise for further development to discover new potent antituberculosis leads.
Page(s): 1144-11552025-01-01T00:00:00ZEsterification of levulinic acid with alcohol catalyzed by hierarchically porous ZSM-5 zeolites: A study on catalyst efficiency and product selectivityManikandan, KShalini, ADeepa, KKaladevi, GValarmathi, NMuthuvel, IThirunarayanan, Ghttp://nopr.niscpr.res.in/handle/123456789/669892025-12-24T05:31:53Z2025-01-01T00:00:00ZTitle: Esterification of levulinic acid with alcohol catalyzed by hierarchically porous ZSM-5 zeolites: A study on catalyst efficiency and product selectivity
Authors: Manikandan, K; Shalini, A; Deepa, K; Kaladevi, G; Valarmathi, N; Muthuvel, I; Thirunarayanan, G
Abstract: This study evaluates the catalytic performance of ZSM-5 zeolites synthesized using corn stem pith powder as a hard
template in the esterification of levulinic acid with 1-proponal and heptanol. The structural and textural properties of the
zeolites have been characterized, revealing a hierarchical porous nature. The catalytic activity of the ZSM-5 is assessed in
the esterification of levulinic acid with 1-propanol and heptanol, yielding corresponding esters with high selectivity. The
effects of reaction parameters, including temperature, molar ratio, catalyst loading, and reaction time, are systematically
studied to optimize reaction conditions. The reusability and stability of the catalyst are evaluated through multiple reaction
cycles. The results are compared with those obtained using conventional ZSM-5, highlighting the advantages of the meso
porous structure. This study provides valuable insights into the design of hierarchical zeolite catalysts for green and
sustainable chemistry applications. The use of corn stem pith powder as a hard template enhances the textural properties of
the zeolite while promoting sustainability and resource efficiency.
Page(s): 1156-11632025-01-01T00:00:00Z