NOPR Collection:

1,3-Dipolar cycloaddition reactions: Synthesis and antimicrobial activity of novel 1-triazolylethylindole and 1-triazolylethylbenz[g]indole derivatives

2010-05-31T16:30:26Z

Title: 1,3-Dipolar cycloaddition reactions: Synthesis and antimicrobial activity of novel 1-triazolylethylindole and 1-triazolylethylbenz[g]indole derivatives Authors: Bhovi, Manjunath G; Gadaginamath, Guru S Abstract: Indole azide 4 and benz[g]indole azide 12 are reacted separately with dimethyl acetylenedicarboxylate to secure the desired 1-[4,5-dimethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole 5 and 1-[4,5-dimethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylbenz[g]indole 13, respectively. The reaction of indole azide 4 and benz[g]indole azide 12 with ethyl propiolate has been found to be regiospecific and produce only the 1-[4-ethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole 6 and 1-[4-ethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylbenz[g]indole 14, respectively. Indole azide 4 is also reacted with ethyl phenylpropolate to secure two isomeric products 1-[4-ethoxycarbonyl-5-phenyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole 8 and 1-[4-phenyl-5-ethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole 9. All these newly synthesised compounds are screened for their antimicrobial activities. Page(s): 1068-1073

Synthesis and antimicrobial activity of 10N-{[(Aryl)-amino]-methyl}-3-methoxy-10,10 – dihydro -4 -H-phenothiazine-9-carboxylic acid

2010-06-02T16:30:48Z

Title: Synthesis and antimicrobial activity of 10N-{[(Aryl)-amino]-methyl}-3-methoxy-10,10 – dihydro -4 -H-phenothiazine-9-carboxylic acid Authors: Radadiya, V R; Purohit, D M; Patolia, V N Abstract: The titled compounds 3a-r have been synthesized by the reaction of 3-methoxy-9-carboxy phenothiazine, formaldehyde and arylamine in the presence of hydrochloric acid (Mannich reaction). The biological activity of these compounds have been determined againsts various Gram +ve, Gram -ve bacteria and fungi. The constitution of the products are supported by IR, PMR and elemental analysis. Page(s): 1112-1114

Cyclodehydration reaction in water medium leads to library/multigram synthesis of 1,5-diarylpyrazoles

2010-05-31T16:30:38Z

Title: Cyclodehydration reaction in water medium leads to library/multigram synthesis of 1,5-diarylpyrazoles Authors: Singh, Sunil K; Saibaba, V; Rao, Y Koteswar Abstract: The cyclodehydration reaction leading to 1,5-diarylpyrazoles in water medium has been observed for the first time. The method has been used in generating library of compounds for drug discovery program under microwave condition and tried for a multigram synthesis of celecoxib, a premier COX-2 inhibitor, under normal laboratory condition. Page(s): 1115-1118

Determining ring-F configuration in spirostane-type steroidal sapogenins by ¹H NMR

2010-06-02T16:30:42Z

Title: Determining ring-F configuration in spirostane-type steroidal sapogenins by ¹H NMR Authors: Agrawal, Pawan K Abstract: A comparison of ¹H NMR chemical shifts for 25R and 25S spirostane-type steroidal sapogenins and saponins suggest that orientation of 27-Me group has quite a different influence on chemical shifts of the methylene protons occupying -and -positions, thus providing valuable information about the establishment 25R-and 25S-stereochemistry in these compounds. Page(s): 1092-1094

NOPR Collection:

1,3-Dipolar cycloaddition reactions: Synthesis and antimicrobial activity of novel 1-triazolylethylindole and 1-triazolylethylbenz[g]indole derivatives

Synthesis and antimicrobial activity of 10N-{[(Aryl)-amino]-methyl}-3-methoxy-10,10 – dihydro -4 -H-phenothiazine-9-carboxylic acid

Cyclodehydration reaction in water medium leads to library/multigram synthesis of 1,5-diarylpyrazoles

Determining ring-F configuration in spirostane-type steroidal sapogenins by 1H NMR

Determining ring-F configuration in spirostane-type steroidal sapogenins by ¹H NMR