NOPR Collection:

A new solid acid catalyst FeCl₃/bentonite for aldol condensation under solvent-free condition

2016-02-01T00:00:00Z

Title: A new solid acid catalyst FeCl₃/bentonite for aldol condensation under solvent-free condition Authors: Muthuvel, I; Dineshkumar, S; Thirumurthy, K; Rajasri, S; Thirunarayanan, G Abstract: For the first time, a new solid acid catalyst has been used for the synthesis of aryl chalcones under solvent free conditions. A simple method (solid dispersion method) has been adopted for the synthesis of FeCl₃/bentonite. The prepared catalyst has been characterized by different characterization techniques. A series of E-1-(substituted phenyl)-3-(1-pyrenyl)-2-propen-1-ones have been synthesized using FeCl₃/bentonite under microwave-assisted solvent-free conditions. The yields are in the range from 80 to 88%. All the synthesized chalcones have been characterized by their physical constants, analytical, IR, ¹H and ¹³C NMR spectral data. This catalyst can be reused for further runs (after fifth cycle) without decrease in activity. This catalyst gives excellent yields and is inexpensive and easily recyclable for this reaction. Page(s): 252-260

Study on the antiproliferative activity of four Schiff bases derived from natural biomass dehydroabietylamine

2016-02-01T00:00:00Z

Title: Study on the antiproliferative activity of four Schiff bases derived from natural biomass dehydroabietylamine Authors: Luo, Hui; Sui, Yan; Lin, Wen-Hua; Wu, Hong-Qin Abstract: Four Schiff bases (1-4) have been obtained by the reaction of dehydroabietylamine and 5-fluoro-2-hydroxybenzaldehyde, 5-chloro-2-hydroxybenzaldehyde, 5-bromo-2-hydroxybenzaldehyde and 2-hydroxy-5-nitrobenzaldehyde, respectively. They have been evaluated for their antiproliferative activities over A549, NCI-H460 and SW620. Among them, 4 exhibits the highest antiproliferative activity. IC₅₀ values are only 8.27, 2.98 and 7.14 μM for NCI-H460, SW620 and A549 cell lines, respectively. Page(s): 248-251

Synthesis of some piperazinobenzoxazole derivatives and their antimicrobial properties

2016-02-01T00:00:00Z

Title: Synthesis of some piperazinobenzoxazole derivatives and their antimicrobial properties Authors: Arisoy, Mustafa; Temiz-Arpaci, Ozlem; Kaynak-Onurdag, Fatma; Ozgen, Selda Abstract: A series of 2-(p-substitutedphenyl/benzyl)-5-[3-[4-[(p-chlorophenyl)/phenyl]piperazin-1-yl]propionamido]-benzoxazoles (3-22) have been synthesized towards discovering new antimicrobial compounds in order to fight against pathogens, which have become resistant to antibiotics and are the cause of increased mortality and morbidity throughout the world. Structures of new derivatives have been elucidated by spectral techniques. New and previously synthesized benzoxazoles have been evaluated for their antibacterial and antifungal activity against standard strains, and their drug-resistant isolates in comparison with reference drugs. This study is aimed to investigate the efficacy of the antimicrobial effect of different amido bridges on the same homologue structures of benzoxazole compounds. Compounds 3-22 exhibit broad antibacterial activity with MIC (Minimum Inhibitory Concentration) values of 128-256 µg/mL against Staphylococcus aureus and its isolate except for derivative 7 that has a MIC value of 32 µg/mL against S. aureus isolate and compounds 3 and 22 which have MIC value of 512 µg/mL against S. aureus. Also, the tested compounds 3-22 possess low antifungal activity with MIC values of 128 µg/mL against Candida albicans in comparison with antifungal reference drugs, fluconazole and amphotericin B. Page(s): 240-247

Synthesis of 1,2,3-triazole glycosides as anticancer agents

2016-02-01T00:00:00Z

Title: Synthesis of 1,2,3-triazole glycosides as anticancer agents Authors: Srinivas, A; Sunitha, M Abstract: A series of novel 1,2,3-Triazole glycosides have been prepared by the addition reaction of O-methyl allose aldehyde with Grignard reagent. Subsequent treatment with TMSN₃ gives the corresponding azide, which on reaction with alkynes gives 1,2,3-triazole glycosides. Characterization of all the compounds has been carried out by IR, ¹H NMR, mass spectroscopy and elemental analysis. Anticancer activity of the compounds has also been evaluated. Page(s): 231-239

NOPR Collection:

A new solid acid catalyst FeCl3/bentonite for aldol condensation under solvent-free condition

Study on the antiproliferative activity of four Schiff bases derived from natural biomass dehydroabietylamine

Synthesis of some piperazinobenzoxazole derivatives and their antimicrobial properties

Synthesis of 1,2,3-triazole glycosides as anticancer agents

A new solid acid catalyst FeCl₃/bentonite for aldol condensation under solvent-free condition