http://nopr.niscpr.res.in/handle/123456789/55585 2026-10-09T13:11:26Z http://nopr.niscpr.res.in/handle/123456789/55594 Title: Synthesis and characterization of nanoclusters: Inorganic-organic hybrid copper and cobalt containing arsenotungstates(III) with lone pair on heteroatom incorporating bidentate N-donating ligands Authors: Kaushik, Reetam; Hussain, Firasat Abstract: Three inorganic-organic hybrid nanoclusters of copper and cobalt containing arsenotungstates with lone pair on heteroatom have been synthesized under mild reactions conditions. All the compounds have been characterized by single crystal X-ray diffraction, Fourier transform infrared, UV/visible spectroscopy, thermogravimetric and field emission scanning electron microscopic (FE-SEM) analysis. The compound [NaRb{Cu(phen) (H₂O)₂Cl}₂][{Cu(phen)(H₂O)}₂{Cu(phen)(H₂O)Cl}₂{Cu₂As₂W₁₉O₆₇(H₂O)] <strong>(1a)</strong> is a sandwiched type arsenotungstate with two copper atoms in square planar environment in the belt region. The polyanion-<strong>1</strong> is decorated by four copper phenanthroline complexes through a terminal oxygen atom of the polyanion. In addition, two other cobalt containing inorganic-organic hybrid lone pair containing arsenotungstates(III) with 1,10-phenanthroline [NaRbCo(phen)₃][{Co(phen)(H₂O)₃}CoAs₂W₂₀O₆₇(H₂O)₃] <strong>(2a) </strong>and 2,2’-bipyridine[Na₃RbCo(2,2-bipy)₃][CoAs₂W₂₀O₆₇(H₂O)₃] <strong>(3a)</strong> has also been synthesized under mild conditions. The polyanion (<strong>2</strong>) is a mono cobalt substituted sandwiched type structure that is decorated by a cobalt phenanthroline complex attached to the polyanion through a terminal oxygen atom. Meanwhile the other complex (<strong>3</strong>) is also a monocobalt substituted sandwiched type structure which contains a cobalt 2,2’-bipyridine complex in the cationic part. Polyanion-<strong>1</strong> shows intermolecular π-π stacking interaction between the phenanthroline ligand in the cationic part and one that is attached directly to the polyanion. The compounds are also characterized by FE-SEM analysis and the compound <strong>3a </strong>shows ultra- smooth cuboids with grain size in the range of 1 to several micrometer though some very small irregular particles with the size of a few micrometer were also observed. Page(s): 1602-1608 2020-11-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/55593 Title: In vitro anti-leishmanial activities and structure-activity relationship analysis of new antimony(III) complexes Authors: Tunç, Turgay; Ertabaklar, Hatice; Karacan, Nurcan Abstract: New fourteen antimony(III) complexes of general formula [SbL_nCl₃] (where n= 1 or 2, L =2-aminopyridine, 5-methyl-2-aminopyridine, 2-aminopyrimidine, 4,6-dimethoxy-2-aminopyrimidine, 2-benzyl-2-thiopseudeourea,2-guanidinobenzimidazole, 2-amino-5-thiol-4,6-dimethoxypyrimidine, 2-amino-5-(1H-tetrazol-5-ylthio)-4,6-dimethoxypyrimidine, N-2-pyrimidine, 2-piperidinecarboxamide, N-2-pyrimidine, 2-pyrrolidinecarboxamide, 2-amino-5-(1H-tetrazol-5-iltiyo)-4,6-dimethoxypyrimidine-2-pyrrolidinecarboxamide and N-2-pyrimidine, 5-chloro-2-thiophenecarboxamide, N-2-benzothiazol-2-pyrrolidinecarboxaamide, N,N-(1,2-phenyl)dipyrrolidine-2-carboxamide) have been synthesized and their anti-leishmanial activity have been assessed in vitro against <em>Leishmania tropica</em> promastigotes. The best complex, Sb(2-guanidinobenzimidazole)Cl₃ is demostrated 3.16% growth inhibition at a concentration of 31.25 μg/mL. In general, antimony(III) complexes containing pyrimidine ligands has showed higher anti-leishmanial activity than antimony(III) complexes bearing pyridine ligands, and electron-donating substituents decrease the anti-leishmanial activity. All complexes have been optimised with DFT/B3LYP/LANL2DZ method in the gas phase. Several descriptors are tested to find a quantitative correlation between anti-leishmanial activity and structural properties of the complexes by best multiple linear regression method. Good correlations are obtained with minimum net atomic charge for a C atom and maximum bond order of a Cl atom. The developed QSAR equation is internally validated. Page(s): 1609-1617 2020-11-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/55592 Title: Nickel(II) complexes of m-ethylphenylxanthate with nitrogen donors and their biological screening Authors: Sharma, Shivangi; Sachar, Renu; Bajju, G D; Sharma, Vikas Abstract: A series of five adducts of m-ethylphenylxanthate of nickel(II) [(m-C₂H₅C₆H₄OCS₂)₂Ni] with nitrogen donors have been synthesized in 1:2 molar ratio by the reaction of aqueous solution of NiCl₂.6H₂O with aqueous solution of sodium salt of m-ethylphenylxanthate. These metal complexes are reacted with nitrogen donors to give donor stabilized complex, [(m-C₂H₅C₆H₄OCS₂)₂(L)₂Ni] where, L= 2-, 3-, 4-ethylpyridine and 2-, 3-chloropyridine. The adducts have been characterized by elemental analysis, molar conductance and magnetic susceptibility measurements, IR, electronic, mass spectral studies, thermogravimetric analysis, powder X-ray diffraction, biological studies. The spectral studies have revealed the octahedral coordination of ligands around Ni(II) metal ion. The adducts are found to be paramagnetic and non-ionic in nature. Mass studies show the monomeric nature of the adducts. The complexes have depicted potential antifungal activity against <em>Bipolaris maydis</em> and <em>Rhizoctonia solani</em>. Some of the synthesized Ni(II) xanthate complexes display <em>in vitro </em>cytotoxic efficacy against human cancer cell lines. Page(s): 1618-1626 2020-11-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/55591 Title: 3,6-Di(pyridin-2-yl)-1,2,4,5-s-tetrazine capped-gold nanoparticles as an efficient antibacterialagent against gram-positive Bacillus subtilis Authors: Joardar, Sutapa; Ray, Shounak Abstract: In current work, we present 3,6-di(pyridin-2-yl)-1,2,4,5-s-tetrazine (pytz) capped gold nanoparticles (TzAuNPs) as an potent antibacterial agent against Gram-positive bacteria. The antibacterial properties of TzAuNPs have been studied using Gram-positive <em>Bacillus subtilis </em>(ATCC 11774) by the plate count method and TzAuNPs is found to be highly effective against the strain. Furthermore, TzAuNPs also show significantly better antimicrobial activity against the bacterial strain when compared to pytz. The effect of TzAuNPs on the bacterial cell wall is also investigated by TEM analysis. This new antimicrobial material could be promising in future for the treatment infectious diseases caused by Gram-positive bacteria. Page(s): 1627-1631 2020-11-01T00:00:00Z