NOPR Collection:

Efficacy and safety of a Unani compound drug– Habb-e-Asgand in Waja‘al-Mafāsil (Rheumatoid Arthritis) cases- A preliminary study

2021-01-01T00:00:00Z

Title: Efficacy and safety of a Unani compound drug– Habb-e-Asgand in Waja‘al-Mafāsil (Rheumatoid Arthritis) cases- A preliminary study Authors: Verma, R S; Khan, P; Ayub, S; Afza, S; Akhtar, J; Ahmad, S; Khan, A A Abstract: Rheumatoid arthritis affects about 24.5 million people worldwide as of 2015. Modern medicine still eludes satisfactory cure for this problem. Therefore, world is looking forward for some traditional medicines in this direction. In the present work, therapeutic efficacy of a Unani compound drug Habb-e-Asgand has been evaluated at Regional Research Institute of Unani Medicine (RRIUM), Aligarh, during 2016-2018. A total of 68 patients were selected from the lot of patients attending outpatient department (OPD). The drug Habb-e-Asgand was given 2 tablets for 84 days and results evaluated statistically by one-way analysis of variance (ANOVA) followed by Dennett’s’ test. The results of the present study were evaluated on clinical, biochemical, and haematological parameters have amply demonstrated that the drug Habb-e-Asgand is therapeutically effective in the treatment of Waja ‘al-mafasil (rheumatoid arthritis). The study has also shown the drug non-toxic and safe. Further studies are suggested in large population. Page(s): 8-14

Evaluation of efficacy and safety of a polyherbal Unani formulation in diabetes mellitus type 2 (Zayābīṭus Sukkari Qism Sāni) - a randomised controlled clinical study

2021-01-01T00:00:00Z

Title: Evaluation of efficacy and safety of a polyherbal Unani formulation in diabetes mellitus type 2 (Zayābīṭus Sukkari Qism Sāni) - a randomised controlled clinical study Authors: Ahmad, N; Nawab, M; Kazmi, M H; Fatima, S H Abstract: Diabetes mellitus type 2 (Zayābīṭus Sukkari Qism Sāni) is a major health concern in 21st century. Despite tremendous advances in modern sciences, there is a lack of relatively safe and effective drug for its management.
The primary objective of this study was to evaluate the efficacy and safety of a polyherbal Unani formulation containing Gurmar booti (Gymnema sylvestre), Gilo (Tinospora cordifolia) and Jamun (Syzygium cumini) in the management of Diabetes Mellitus Type 2 (DMT2). It was a randomised controlled clinical study conducted on 60 participants of DMT2 inadequately controlled by diet and exercise. The test drug was given to group-A participants (n=30) 6 g twice daily orally for 12 weeks and the standard drug metformin (500 mg) was given twice daily orally to group-B participants (n=30).
It was observed that the difference between the Mean (± SD) value of fasting blood glucose (FBG), postprandial blood glucose (PPBG) and glycosylated haemoglobin (HbA1c) in Test and Control groups at the end of the study in comparison to baseline was significant (p<0.05). This study concludes that the test drug was effective in reducing FBG and PPBG significantly in diabetic participants’ at 12 weeks of treatment. Page(s): 15-20

Quality control measure of Jeeva Rasa Avaleha: a male sexual stimulant

2021-01-01T00:00:00Z

Title: Quality control measure of Jeeva Rasa Avaleha: a male sexual stimulant Authors: Kumar, V; Yadav, K D; Singh, T D; Chaudhary, A K Abstract: In spite of numerous Vajeekarana formulations being available in the market, the prevalence erectile dysfunction is increasing irrespective of race or economic status. The aim of the present study was to measure the quality control parameters of Jeeva Rasa Avaleha used as male sexual stimulant. It was prepared by using seven drugs, namely Shuddha Hingula, Shuddha Shilajatu, with powders of roots of five herbs viz., Aakarakarabha, Ashwagandha, Shweta Mushali, Shatavari and tuber of Vidarikanda. Qualitative and quantitative analyses of JRA such as reducing sugar, non-reducing sugar, fat content, water soluble extractive, pH, thin layer chromatography (TLC) and energy dispersive x-ray spectroscopy (EDX) were performed. It was observed that 9.8% moisture content and 15.12% water-soluble extractive were in JRA, respectively. EDX and AAS study showed that formulation had heavy metals within permissible limit except mercury which is an ingredient of JRA. Both qualitative and quantitative analysis of JRA indicates safety of formulation and therefore it may be prescribed for the treatment of erectile dysfunction. Page(s): 21-25

Phytochemicals and antioxidant activity of Sisymbrium irio L. seeds

2021-01-01T00:00:00Z

Title: Phytochemicals and antioxidant activity of Sisymbrium irio L. seeds Authors: Hailu, T; Gupta, R K; Rani, A Abstract: Sisymbrium irio (Family: Cruciferae) is used in Unani medicine. The qualitative and quantitative analysis showed the presence of different types of bioactive secondary metabolites for like phenols, flavonoids, saponins, terpenoids, except reducing sugar and cardiac glycosides. The antioxidant activity was checked by DPPH and ABTS free radical trapping methods by using standards such as ascorbic acid and trolox. The methanol extract of the Indian variety of the seeds of Sisymbrium irio showed a very high antioxidant activity. The major pharmacological bioactive chemical compounds identified in different solvent extracts of Sisymbrium irio were characterized as: 2, 4-Di-tert-butylphenol, n-Hexadecanoic acid, 3’, 5’-Dimethoxyacetophenone, γ -Tocopherol, Cholesterol, 1-Nonedecene, γ -Sitosterol, Ergot-5-en-ol, (3- Beta, 24R)-3- Methylcrotononitrile, 1, 2 - Cyclopentadi-one, 1, 3 - Cyclohexanedione, 4-Isothiocyanato-1-Butene, Isosorbide, Sinapic acid methyl ester, 1, E-8, Z-10-Pentadecatriene and 7-Tetradecenal, (Z) and GC-MS fatty acid composition of the cold pressed seeds oil of plant showed the presence of major fatty acids such as: Linolenic acid (36.29%), Linoleic acid (17.99%), Oleic acid (12.58%), cis-11-Eicosanoic acid (9.2%), Erucic acid (9.19%) and Palmitic acid (6.66%). The elemental analysis of the seeds showed the presence of magnesium, calcium, strontium, titanium, chromium, manganese, copper, zinc, boron, aluminium, silicon, barium, iron, phosphorus, sodium, potassium and lead. Page(s): 26-32