http://nopr.niscpr.res.in/handle/123456789/60026 2026-10-11T12:37:43Z http://nopr.niscpr.res.in/handle/123456789/60038 Title: ZnO nanoparticles catalyzed C–N bond-forming reactions: A highly efficient protocol to convert electron-deficient anilines to formanilides Authors: Saikia, Tulan Chandra; Iraqui, Saddam; Rashid, Md. Harunar Abstract: Herein, we report a protocol for the conversion of electron-deficient anilines to formanilides at room temperature using ZnO nanoparticles (NPs). The ZnO NPs of different shapes have been synthesized by conventional co-precipitation techniques and are characterized fully using different microscopic, diffractometric and spectroscopic techniques. The developed protocol is simple, green, inexpensive, and highly efficient. The products can be conveniently separated from the reaction mixture without using the conventional tedious and expensive chromatographic techniques. The protocol is effective for a wide range of substituted anilines, aliphatic amines and heterocycles with moderate to excellent yield. The catalyst is highly stable and is reusable up to the 5th cycle without loss of catalytic activity. Page(s): 573-581 2022-06-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/60037 Title: Design, synthesis and in vitro antimicrobial activity of fused pyridine-pyrimidine hybrids Authors: Desai, Nisheeth C; Khasiya, Ashvinkumar G Abstract: The antimicrobial resistance (AMR) is defined as the rising global concern of infectious illnesses that are resistant to all known antimicrobial agents. As the microbial resistance is increasing recently against the present therapeutics, there is an urgency to discover the novel antimicrobial agents. Due to this reason, we have synthesized a series of novel pyridinepyrimidine derivatives (4a-o) for the development of antimicrobial agents. The structures of these bioactive molecules were determined using IR, 1H NMR, 13C NMR, and mass spectroscopy. The titled compounds were tested for antimicrobial activity against various bacterial and fungal strains using Chloramphenicol and Griseofulvin as standard drugs. Compounds 4b, 4d and 4m exhibited excellent antibacterial activity with MIC = 62.5 μg/mL against E. coli, S. aureus and S. pyogenes respectively. Compounds 4g and 4o showed prominent activity against C. albicans with MIC value of 250 μg/mL. Page(s): 582-590 2022-06-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/60036 Title: Pharmacological evaluation of some synthesized thiazolidinone derivatives containing Mannich base of sydnone and p-phenylenediamine Authors: Savant, Suchitra S; Vashi, Parikshit I; Gamit, Elit A; Patel, Keshav C; Patel, Paresh S Abstract: A series of 4-thiazolidinone derivatives incorporating Mannich base of 3-(3-nitrophenyl)sydnone have been synthesized by conventional routes and evaluated for their antimicrobial activities against E. coli, P. aerugenosa, S. aureus, S. pyogenus, C. albicans, A. niger and A. clavatus. Most of the compounds show moderate to very good biological activity. The structures of synthesized compounds 7a-j have been elucidated by C, H, and N analysis, FT-IR, 1H and 13C NMR and mass spectrometry. Page(s): 591-598 2022-06-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/60035 Title: Synthesis of 9,9-dimethyl-12-(aryl)-8,9,10,12-tetrahydrobenzo[a]xanthene-11- ones by modified kaolinite nanoclay as an efficient and reusable heterogeneous catalyst via a green protocol Authors: Bamoniri, Abdolhamid; lou, Reza Delqavi Khalifa; Yaghmaeiyan, Nahid Abstract: 9,9-Dimethyl-12-(aryl)-8,9,10,12-tetrahydrobenzo[a]xanthene-11-one derivatives have been prepared via three component reaction of various aromatic aldehydes, dimedone and 2-naphthol. This green methodology has been effectively catalyzed by sulfonyl- functionalized kaolinite nanoclay (nano-kaolin-SO3H) as a recoverable solid catalyst. This type of solid acid which contains the properties of a Lewis acid (Al3+cation) and a Brønsted acid (SO3H group), has been characterized by ATR, TEM, FESEM, EDS, EDS mapping, XRD, TGA, BET and XRF techniques. Compared with conventional methods, this protocol has promising features for the reaction response such as simplicity in the experimental procedure, easier work-up, shorter reaction times and ease of separation of pure products with high yields. Page(s): 599-606 2022-06-01T00:00:00Z