http://nopr.niscpr.res.in/handle/123456789/60673 2026-10-12T21:14:01Z http://nopr.niscpr.res.in/handle/123456789/60688 Title: Dactylorhiza hatagirea (D. Doon) Soo, an important medicinal herb of the Himalaya and urgent need for its conservation- A review Authors: Dorjey, Konchok; Maurya, Arum Kumar; Sinha, Dwaipayan Abstract: Dactylorhiza hatagirea (D. Doon) Soo (Family Orchidaceae) is a terrestrial orchid, native to alpine and sub-alpine zones of Himalaya, well known for medicinal uses because of its immense pharmacological properties and therapeutic potential. Leaves and tubers of the herb finds enormous uses in traditional Indian medicinal system like Ayurveda, Siddha, Unani and Sowa-rigpa for treatment of different ailments like dysentery, diarrhoea, chronic fever, cough, wounds, burns, fractures, stomach-ache, etc. The present review analyses the distribution, medicinal uses, phytochemistry, pharmacology, and conservation status of D. hatagirea. The review is based on literature available on this orchid with an objective to compile and understand diverse medicinal uses among the indigenous Himalayan communities and phytochemical potential in pharmacology. This review also highlights the potential threats faced by this orchid and suggests future conservation prospects and strategies. Page(s): 265-273 2022-10-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/60687 Title: Ethno medicinal plants with anticonvulsant activity through GABAergic mechanism- A review Authors: Jangra, Sachin; Manjusha; Budhwar, Vikas Abstract: Humanity has used immemorial plants for their relieving and healing powers from era and we still depend on their healing properties. Plants with number of active constituents have a direct therapeutic impact on various body organs. Brain is one of major organ linked to various disorders, one of them is epilepsy. Owing to undesirable side effects, high expense and reduced effectiveness of conventional drugs, traditional plants are deemed appropriate for the treatment of epilepsy. The potential of natural products for the treatment of epilepsy can be an excellent alternative for the development of safe and effective anti-epileptic drugs. The present bibliographic review presents the data upto 2021. Plants were screened for citing the research work done for epilepsy, efficacy of plants along with their mechanism of action, plant profile, part used, dose, extract used, toxicity study and model used. Also isolated compounds have been compiled along with their structure. A total of 120 review and research articles of plants which revealed their effective therapeutic effects on epilepsy through GABAergic transmission belonging to families lamiaceae(11), fabaceae(5), zingiberaceae(3), moraceae(3), verbenaceae(3), and apiaceae(2). The data discussed might be useful in formulating new chemical entity for the treatment of epilepsy. The documentation of isolated compounds may provide new drug molecules for market with lesser cost and more efficacy. Page(s): 274-286 2022-10-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/60686 Title: Industrial applications of Ananas comosus wastes as valuable and utilizable products-A review Authors: Soni, Shashi; Noor, Uroosa; Gupta, Ena Abstract: Ananas comosus, tropical fruit from Bromeliaceae family, is known for its flavour with major application in a number of industries viz juice, canned pulp, fruit candy, jam, jelly, wine, vinegar, bromelain extraction and many more. Large amounts of by-products are generated from these industries in which peel alone accounts for 34-38%. These by-products are discarded as waste and causes serious environmental pollution. Researchers have investigated that these by-products, mainly peels are potential sources of many nutritional and bioactive compounds which exhibits numerous health benefits. The present application of the waste is to convert it into value added products and currently, it is utilized in many industries such as chemical industry, health sectors, food sector, pharmaceuticals, and nutraceuticals. This article summarizes the major applications of A. comosus peel at industrial level. ‘Industrial applications’ is an umbrella term in which biofuel generation; enzyme production; bromelain extraction; cellulose, bacterial cellulose, nanocellulose and nanocrystalline cellulose; nanoparticles synthesis; biorefinery production; superabsorbent hydrogel formation; oil extraction; wine and vinegar production; supplementation; fortification; enrichment etc. terms are embedded. Page(s): 287-300 2022-10-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/60685 Title: Biologically active Naneoicglycolate of Aristolochia littoralis Parodi seed extract with anti-bacterial activity induces cytotoxicity and apoptosis in A431 human skin cancer cell line Authors: K, Thara N; P, Raghavendra M Abstract: Aristolochia littoralis Parodi is an important traditional medicinal plant known for centuries. In this study, antibacterial and anti-cancerous properties of seeds of this plant were investigated. Experimentally chloroform, ethanol, and aqueous extracts were screened for antibacterial activity against Escherichia coli and Staphylococcus aureus. The extracts were further analyzed for anticancer activity against human skin carcinoma A431 cell lines by 3-(4,5-dimethylthiazol-2-yl)-2-5- diphenyl tetrazolium bromide (MTT). The fraction comprising the biomolecule responsible for anticancerous activity was purified by TLC and HPLC. It was subjected to 1H NMR, 13C NMR, and Mass spectrophotometer for structural elucidation. The purified active principle was quantitatively evaluated for inducing apoptosis in A431 skin cancer cell line by flow cytometry analysis. Phytochemical analysis of solvent extracts revealed the presence of alkaloids, steroids, carbohydrates, tannins, and resins. Antibacterial activity was observed in the aqueous and ethanol extracts against the test pathogenic bacteria. Among the solvent extracts, chloroform extract revealed a highly significant anticancer/cytotoxic activity on A431 cell lines. The data revealed that the bioactive principle present in the A. littoralis Parodi seed is naneoicglycolate with molecular formula C20H34O4 and was found to be highly cytotoxic at IC50 81.02 μg\mL against A431 cell line. The present study is successful in identifying a novel bioactive principle from an underutilized plant/weed with significant anticancer activity. Page(s): 301-309 2022-10-01T00:00:00Z