http://nopr.niscpr.res.in/handle/123456789/62308 2026-10-09T13:10:47Z http://nopr.niscpr.res.in/handle/123456789/62320 Title: Synthesis and antituberculosis action of symmetric acridin-9-yl-bisbenzothiazol- 2-yl-amines Authors: Kawle, Pravin R Abstract: A new series of symmetric acridin-9-yl-bis-benzothiazol-2-yl-amines have been synthesized in good to excellent yields by intra-molecular cyclization of 1-acridin-9-yl-1-benzothiazol-2-yl-3-aryl thiourea and screened for their in vitro antitubercular activity against Mycobacterium tuberculosis by BACTEC radiometric method. The synthesis of new analogues bearing an acridine-linked chloro-substituted benzothiazole has demonstrated enhanced antituberculosis activity. Page(s): 691-695 2023-07-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/62319 Title: Thiophene functionalized naphthalene diimide for the sensitive detection of nitroaromatics Authors: Bhusanur, Dnyaneshwar I; Singh, Prabhat K; Bhosale, Sheshanath V; Bhosale, Sidhanath V Abstract: In recent years, the detection of nitroaromatics (NACs) has attracted the researchers’ attention due to increased threats of terrorist and environmental protection. In this regard, tetra-thiophene (Th) functionalized naphthalene diimide (NDI) conjugate NDI-Th has been synthesized and confirmed via spectroscopic methods. UV-Vis and fluorescence methods have been utilized to examine the photophysical characteristics of NDI-Th in various solvent systems. Moreover, NDI-Th as a fluorescent sensor displays selective recognition of 2,4-dinitrophenol (DNP) and 2,4-trinitrophenol (TNP) with a limit of detection of 4.74×10–8 M and 7.60×10–8 M, respectively. Thus NDI-Th acts as a promising candidate for explosive multi-NACs detection. Page(s): 696-702 2023-07-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/62318 Title: Synthesis, quantum chemical computation, molecular docking analysis and biological activity of chlorophenyl thiazolyl naphthyl methanone as dendrodoine analogs Authors: Brilla, C; Reji, T F Abbs Fen Abstract: A series of chlorophenyl thiazolyl naphthyl methanone derivatives have been synthesized and found to possess a wide spectrum of biological activities. Chlorophenyl thiazolyl naphthyl methanone has been synthesized and characterized by elemental analysis IR, 1H and 13C NMR and mass spectral data. Quantum chemical computation and vibrational spectral analysis of chlorophenyl thiazolyl naphthyl methanone have been carried out using DFT level B3LYP with 6-31G basis set. Electric dipole moment (μ) values have been computed by utilizing ab initio and DFT quantum mechanical calculations. The energy gap is an indicator of chemical reactivity, kinetic stability and polarizability. The novel compounds show very good antioxidant and anticancer activity. Docking studies have been performed for target molecules using the molecular docking software. The antioxidant activity of chlorophenylthiazolylnaphthylmethanone has been analyzed using the DPPH radical scavenging assay. Among the studied compounds, (4-chlorophenyl-2-diethylaminothiazol-5-yl-2-naphthyl)methanone 2b is highly active on the SKMEL cell line. Page(s): 703-713 2023-07-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/62317 Title: Schiff base metal complexes: Synthesis, characterisation, and antibacterial properties Authors: Vainala, Madhukar; Jyothi, Sunkari; Shamili, Sriramoju Abstract: Five novel metal complex derivatives from the 2N-salicylidene-5-(p-amino phenyl)-1,3,4-thiadiazole (HL) in alcoholic medium have been effectively synthesised by combining HL with the metal ions Vo(II), Co(II), Rh(III), Pd (II) and Au(III). Except for the Vo(II) and Co(II) complexes, which have square pyramidal and tetrahedral geometries, all of the complexes have a monomeric structure, with the metal centre moieties being four-coordinated. HL has been shown to be more effective in vitro against the tested bacteria and complexes 1–5 have been found to have greatest antibacterial activity relative to the standard antibiotic (Kanamycin). Page(s): 714-719 2023-07-01T00:00:00Z