http://nopr.niscpr.res.in/handle/123456789/67252 2026-10-11T23:41:44Z http://nopr.niscpr.res.in/handle/123456789/68636 Title: An overview of Livestock-Associated MRSA: prevalence, lineages, and treatment Authors: Gurumurthy, Sanjana; Hritvik Nair, Kallumparambath; Kumari S, Chaitanya Abstract: The objective of this review is to provide an updated overview of Livestock-Associated MRSA (LA-MRSA), highlighting its global prevalence, clonal lineages, transmission across animal host, and current treatment strategies with One Health perspective. Staphylococcus aureus is a Gram-positive, opportunistic, facultative anaerobe found in skin and mucosal layers of the human body. Livestock Associated Methicillin Resistant Staphylococcus aureus (LA-MRSA) is one of the three types of MRSA classified based on epidemiological characteristics. Notorious strains of MRSA were found majorly in cities within Eastern Asia, South America, Europe and smaller regions scattered across other continents. Several lineages (like CC398, CC130, CC97 etc.) affect a wide variety of animals and their species along with transfer of infection to humans. LA-MRSA could cause many different issues including contamination of meat sold in markets leading to sickness amongst humans and infection amongst domestic animals which live in the same homes as healthy people. Treatments related to MRSA have been discussed widely from using natural materials to synthesis of new generations of antibiotics. It is stated that antibiotic resistance could emerge as one of the major causes for high mortality rate worldwide by 2050. This review will give an overview on the threat, prevalence, lineages and treatment of LA-MRSA and peek into the future of antibiotic resistance. Page(s): 897-914 2026-10-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/68635 Title: Pharmacological attribute, LC-MS/MS profiling and in-vitro bioactivity of Silene dichotoma aqueous extract Authors: HAZMAN, Ömer; AKSOY, Laçine; BÜYÜKBEN, Ahmet; Abdullah YILMAZ, Mustafa; ÇAKIR, Oğuz; EFĠLOĞLU, Feyza; Sena ARSLAN, Hanife; COġKUN, Emine; CANDAN, sevval Page(s): 915-925 2026-10-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/68634 Title: Effects of Irisin Combined with Gefitinib on Expression Levels of miRNAs in the HepG2 Cell Line Authors: AYAZ, Lokman; Sancar, Hilal; ŞUMNULU, Deniz Abstract: This study aims to investigate the effects of the combination of irisin and gefitinib on the expression of AKT1, FNCD5, VEGF, Bcl-2, EGFR, PI3K, CDK1, and ERBB2 genes, which play critical roles in the pathogenesis of hepatocellular carcinoma, beside the expression of miRNAs targeting these genes in the HepG2 cell line. MTT assay was applied to evaluate the cytotoxicity induced by irisin or gefitinib. Expressions of miR- 664b-5p, miR-3922-5p, miR-6843-3p, miR- 8085, miR-381-5p, miR-1275, miR-1304, and miR-6801-5p, and the expression of target genes of these miRNAs were determined by RT-PCR. The most effective time for the combination of irisin and gefitinib in HepG2 cells was 48 hours, and the dose was 3.125 μM for irisin and 10.34 μM for gefitinib. PI3K, Akt, EGF, and ErbB2 expressions were significantly decreased in irisin groups compared to the control group. We found that irisin alone and in combination with gefitinib increased miR-664b-5p, miR-381-5p, miR-3922-5p, miR-1275, and miR-1304 gene expressions, whereas the combined treatment of irisin with gefitinib decreased miR-8085 expression. Our study shows that irisin can enhance the anticancer effects of gefitinib in the HepG2 cell line and dysregulated miRNA expressions contribute to HCC pathogenesis by decreasing cell proliferation and inducing apoptosis. Page(s): 926-931 2026-10-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/68633 Title: Pathological and ultrastructural changes of Adrenal Cortex and their association with Adrenal insufficiency in a Rat Model of Severe Acute Pancreatitis Authors: Liu, Lilei; Zhang, Xingwen; Li, Xiang; Xu, Jing; Pei, Yanfang; Fan, Maiying; Yu, Fang; Wang, Xiangying; Han, Xiaotong Page(s): 932-943 2026-10-01T00:00:00Z