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Ornithine α-ketoglutarate modulates the levels of antioxidants and lipid peroxidation products in ammonium acetate treated rats

Sun, 01 Dec 2002 00:00:00 GMT

Title: Ornithine α-ketoglutarate modulates the levels of antioxidants and lipid peroxidation products in ammonium acetate treated rats Authors: Dakshayani, K B; Velvizhi, S; Subramanian, P Abstract: The effects of ornithine α-ketoglutarate (OKG) on ammonium acetate induced hepatotoxicity were studied in experimental rats. The levels of urea, non-protein nitrogen and thiobarbituric acid reactive substances were significantly increased in ammonium acetate treated rats ; but these levels were significantly decreased in ammonium acetate-OKG treated rats. Similar patterns were observed in the levels of free fatty acids, triglycerides and phospholipids. Furthermore, non-enzymatic (reduced glutathione) and enzymatic (glutathione peroxidise, superoxide dismutase and catalase) antioxidants were significantly decreased in ammonium acetate treated rats. When compared with control and were significantly increased in ammonium acetate-OKG treated rats compared to ammonium acetate treatment alone. Page(s): 422-424

Dietary regulation of adenosine deaminase activity in stomach, small intestine and spleen of mice

Sun, 01 Dec 2002 00:00:00 GMT

Title: Dietary regulation of adenosine deaminase activity in stomach, small intestine and spleen of mice Authors: Ray, Indrani; Sharma, Ramesh Abstract: Activity of adenosine deaminase (ADA) and its regulation by dietary restriction were studied in the stomach, small intestine and spleen of mice. ADA activity (U/mg protein) was highest in the stomach, followed by small intestine and spleen of mice on normal diet. The activity decreased significantly in the stomach (41%) and small intestine (45%) of 24 hr fasted mice, when compared to mice fed ad-libitum. However, ADA activity in spleen did not show any change by dietary intervention. Refeeding of fasted mice for 24 hr restored the activity of ADA in tissues. In addition, dietary restriction (alternate days of feeding for three months) had a cumulative effect, whereby ADA activity decreased significantly in the stomach (53% on the day of feeding and 60% on the day of fasting) and small intestine (50% and 54% on the day of feeding and fasting, respectively) without any change in activity in spleen. These findings indicate that dietary restriction reduces ADA activity in a tissue-specific manner. Long-term dietary restriction leads to a cumulative adaptation in lowering the ADA activity of GIT, but not in spleen. Page(s): 419-421

Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu- Asp- Phe-, a fragment of apolipoprotein B

Sun, 01 Dec 2002 00:00:00 GMT

Title: Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu- Asp- Phe-, a fragment of apolipoprotein B Authors: Srivastava, Shinoo; Srivastava, Seema; Melkani, Girish Chandra; Singh, Shyam; Gupta, Vishwambhar Dayal; Gupta, Vijai Prakash Abstract: The collective normal modes of the hexapeptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B (apo B), have been obtained. They reflect the dynamic nature and are atleast partly responsible for energy input in autolytic activity. Further, on energetic considerations based on the measurements reported by Sim & Sim, it has been shown that of the two such fragments only one induces autolysis, while the other remains anchored to the coated pit. Page(s): 410-418

Transport through liquid membranes containing omeprazole and lansoprazole

Sun, 01 Dec 2002 00:00:00 GMT

Title: Transport through liquid membranes containing omeprazole and lansoprazole Authors: Nagappa, A N; Pandi, P V; Mishra, P K; Girish, Rahul K; Shanmukh, I Abstract: Omeprazole and lansoprazole, the therapeutically important drugs belonging to proton pump inhibitor category are extensively used in the treatment of gastric ulcers. Transport through liquid membranes generated by these drugs in lecithincholeste mixture in series with a supporting membrane has been studied. The data obtained show the formation of liquid membrane in series with the supporting membrane. Transport of cations, chloride and bicarbonate ions in the presence liquid membranes generated by omeprazole and lanzoprazole indicate the modification in the permeability or various permeants. Page(s): 406-409