NOPR Collection:

Synthesis of some thiazolidinones and 5-oxoimidazolines as biologically potent agents

Sat, 01 May 1999 00:00:00 GMT

Title: Synthesis of some thiazolidinones and 5-oxoimidazolines as biologically potent agents Authors: Bhatt, Akhil H; Parikh, Khyati A; Parikh, A R Abstract: 4-Aminobe nzophenone 1 on condensation with different aralclehydes yield schiff's bases 2a-o which on cyclization with mercapto acetic acid afford the corresponding 4-(5'H-2'aryl-4'thiazolidinon-3'-yl)-benzophenones 3a-o. While cyclocondensation of 1 with various azlactones yield 4-(4'-aryl idene-2'-phenyl- 5'-oxo-imidazolin-1'-yl )benzophenones 4a-m. The structure of the compounds have been confirmed from elemental analysis, IR , ¹H NMR and mass spectral data. All the compounds have been evaluated in vitro for antimicrobial and antimycobacterial activities. Page(s): 628-631

Antimony trichloride; a mild, efficient and convenient catalyst for conversion of oxiranes to thiiranes under non-aqueous conditions

Sat, 01 May 1999 00:00:00 GMT

Title: Antimony trichloride; a mild, efficient and convenient catalyst for conversion of oxiranes to thiiranes under non-aqueous conditions Authors: Mohammadpoor-Baltork, I; Khosropoor, A R Abstract: Oxiranes are converted to their corresponding thiiranes in excellent yields (95-98%) using ammoniun thiocyailate and catalytic amounts of antimony trichloride. Page(s): 605-606

Synthesis of steroidal oxazolidinones : Reactions of steroidal epoxides with glycine

Sat, 01 May 1999 00:00:00 GMT

Title: Synthesis of steroidal oxazolidinones : Reactions of steroidal epoxides with glycine Authors: Shafiullah; Shamsuzzaman; Siddiqui, I H; Ansari, S A; Khan, E H Abstract: Reaction of 5, 6-epoxyecholestane 1, its 3β-acetoxy 2 and 3β -chloro 3 analogues with glycine in dimethylformamide using AICI₃ as catalyst gives 5-cholestano[6, 5-d]oxazolidin-2'-one 4. its 3β-acetoxy 5 and chloro 6 analogues, respectively. The structures of these compounds have been established on the basis of their elemental, analytical and spectral data. A mechanism has been suggested for the formation of oxazolidinones 4-6. Page(s): 600-602

Synthesis of 2, 5-disubstituted 1, 3, 4-oxadiazoles as biologically active heterocycles

Sat, 01 May 1999 00:00:00 GMT

Title: Synthesis of 2, 5-disubstituted 1, 3, 4-oxadiazoles as biologically active heterocycles Authors: Kagthara, Preeti R; Shah, Niraj S; Doshi, Rajeev K; Parekh, H H Abstract: 2-(8enzimidazol-2'-yl) benzoyl hydrazide 1 when condensed with aromatic acids in the presence of POCI₃ afforded 2-aryl -5-[2'-benzimidazol-2"-yl) phenyl]-l, 3, 4-oxadiazoles 2a-o. The acid hydrazide 1 on cyclisation with CNBr yield 2-amino-5-[2'-(benzimidazol-2 "-yl-phenyl)- 1, 3, 4-oxadiazole 3 which on reaction with aryl sulphonyl chlorides and substituted benzoyl chloride give the corresponding sulphonaillides 4a-o and amides 5a-o, respectively. All the products have been evaluated in vitro for their antimicrobial activity against several microbes and antitubercular activity against Mycobacterium tuberculosis H37Rv. Page(s): 572-576