NOPR Collection:

Novel flavanone and chalcone glycosides from Clerondendron phlomidis (Verbenaceae)

Mon, 01 Nov 1999 00:00:00 GMT

Title: Novel flavanone and chalcone glycosides from Clerondendron phlomidis (Verbenaceae) Authors: Anam, Edet M Abstract: Oven dried ground roots and flowers of Clerodendron phlomidis yield two flavonoidglycosides, -L-Rharnnopyranosyl-(1→2)--D-glucopyranosy1-7-O-naringin-4'-O--D-glucopyranoside-5-methyl ether 1 and 4, 2', 4'-trihydroxy-6'-methoxychaIcone-4, 4'--D-diglucoside 5. Page(s): 1307-1310

Monoterpenic fragment analogues of Aplasmomycin as potential anti-malarials

Mon, 01 Nov 1999 00:00:00 GMT

Title: Monoterpenic fragment analogues of Aplasmomycin as potential anti-malarials Authors: Kundu, Mrinal K; Thomas, Jacob V; Bhat, Sujata V Abstract: Malaria has become a serious disease throughout recorded history and the protozoan parasite of the family Plasmodidae is known to be the etiologic agent for this. The dangerously improved immunological status of various parasites (especially human malaria parasite P. falciparum) against conventional drugs such as chloroquine necessitates the development of new agents having optimum efficacy. Page(s): 1299-1300

Synthesis of N₈-macrocyclic ligands by polyphosphoric acid-catalysed condensation of trimethoprim with amino acids

Mon, 01 Nov 1999 00:00:00 GMT

Title: Synthesis of N₈-macrocyclic ligands by polyphosphoric acid-catalysed condensation of trimethoprim with amino acids Authors: Amaladasan, M; Paulraj, A; Arulsamy, K S Abstract: Trimethoprim [2,4-diamino-5-(3', 4',5'-trimethoxybenzyl) pyrimidine] reacts with amino acids to give colourless N₈-macrocyclic compounds by the polyphosphoric acid-catalysed condensation. The products contain a cross conjugated macrocyclic system of a novel type, related to some extent to azoporphins. The condensation proceeds to give products which, in certain instances, are not readily attainable by conventional condensation techniques. Page(s): 1282-1284

Kinetics and mechanism of the oxidation of aliphatic aldehydes by benzyltrimethylammonium dichloroiodate

Mon, 01 Nov 1999 00:00:00 GMT

Title: Kinetics and mechanism of the oxidation of aliphatic aldehydes by benzyltrimethylammonium dichloroiodate Authors: Goswami, Garima; Kothari, Seema; Banerji, Kalyan K Abstract: The oxidation of six aliphatic aldehydes by benzyltrimethylammonium dichloroiodate (BTMACI) in glacial acetic acid, in the presence of zinc chloride, results in the formation of the corresponding carboxylic acids. The reaction is first order with respect to BTMACI, the aldehyde and zinc chloride. The oxidation of deuterated acetaldehyde shows the presence of a substantial kinetic isotope effect (k_H/k_D = 6.32 at 288 K). Addition of benzyltrimethylammonium chloride enhances the reaction rate. It is proposed that the reactive oxidizing species is [PhCH₂Me₃N]⁺ [IZn₂Cl₆]^-. The rates correlate well with Taft's σ^● substituent constants, with negative reaction constant. A mechanism involving a hydride-ion transfer from the aldehyde to the oxidant in the rate-determining step, has been postulated. Page(s): 1270-1273

NOPR Collection:

Novel flavanone and chalcone glycosides from Clerondendron phlomidis (Verbenaceae)

Monoterpenic fragment analogues of Aplasmomycin as potential anti-malarials

Synthesis of N8-macrocyclic ligands by polyphosphoric acid-catalysed condensation of trimethoprim with amino acids

Kinetics and mechanism of the oxidation of aliphatic aldehydes by benzyltrimethylammonium dichloroiodate

Synthesis of N₈-macrocyclic ligands by polyphosphoric acid-catalysed condensation of trimethoprim with amino acids