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Synthesis and Fungicidal Activity of Some Furan Containing Azoles

Wed, 01 Dec 1999 00:00:00 GMT

Title: Synthesis and Fungicidal Activity of Some Furan Containing Azoles Authors: Nizamuddin; Gupta, Madhuri; Srivastava, Manoj Kumar Abstract: Some 1-Aryloxyaceto-3-(2¢-furanyl)-5-methyl-2H-1,2,4-triazoles (II), 2-aryl oxymethyl-5-(2¢-furanyl)-1 ,3,4-oxadiazol- [3,2-c)thiazoles (IV) and aryloxyimino-3-aryloxyaceto-5-(2¢-furanyl)- 1 ,3,4 thiadiazoles (V) have been synthesised by the reaction of N^l-(4-tolyloxyaceto)-N² -furfurylidene hydrazides (I) with acetonitrile, mercapto acetic acid, and phenyl isothiocyanate respectively. All the compounds have been assayed for their fungicidal activity against Pyricularia oryzae, Rhizoctonia solani and Aspergillus niger. Page(s): 1017-1020

Estimation of Sodium Content of Various Antacid Preparations by Flame Photometry

Wed, 01 Dec 1999 00:00:00 GMT

Title: Estimation of Sodium Content of Various Antacid Preparations by Flame Photometry Authors: Manna, V; Samanta, A; Pal, D K; Si, A S; Bandopadhyay, S Abstract: Now-a-days antacid formulations are extensively used as over the counter product. Aluminium hydroxide and magnesium hydroxide which are used industrially for the preparation of antacid, generally impart some parts of sodium ion. This sodium ion is particularly harmful to cardiac and hypertensive patients. In the present study, attempt has been made to determine the sodium content of various widely marketed anatacid products. Results suggest that care must be taken during the manufacturing of this hydroxide and certain specifications are needed by the monographs regarding the sodium content of antacid preparations. Page(s): 1021-1022

Development and Characterization of Release Profile of Nifedipine as an Effective Controlled Release System

Wed, 01 Dec 1999 00:00:00 GMT

Title: Development and Characterization of Release Profile of Nifedipine as an Effective Controlled Release System Authors: Mallick, S; Gupta, B K; Ghosal, S K Abstract: To develop an effective controlled drug release system, preparation of microcapsule formulation of nifedipine coated with ethylcellulose, eudragit RS and eudragit RL is reported. Coacervation and phase separation (CPS) technique involving non-aqueous manufacturing vehicles is utilized for the encapsulation of nifedipine in different core-coat ratios without applying high temperature. It is observed that microcapsules coated with eudragit RL exhibit maximum encapsulation efficiency. Drug release kinetics from all the sponge like structured microcapsules follow a matrix controlled mechanism of Higuchi Model rather than the same based on the diffusion process of monoexponential model of the first order. The release rate, dissolultion efficiency and permeabil ity constant could be controlled by the type and concentration of the polymer loading. Controlled release microcapsules produced by the present method can provide characteristic advantages over conventional method of preparing a reservoir device of drug, such as fluid-bed coating or coating of beads. Page(s): 1010-1016

Heat Stability of Lipoxygenase and Peroxidase During Blanching of Vegetables

Wed, 01 Dec 1999 00:00:00 GMT

Title: Heat Stability of Lipoxygenase and Peroxidase During Blanching of Vegetables Authors: Kaur, Charanjit; Kumar, Sushil; Kapoor, Harish C Abstract: French beans, carrots, peas, and bitter-gourd were blanched conventionally and in microwave for different durations. Lipoxygenase and peroxidase were taken as indicator enzymes to test the adequacy of blanching. Lipoxygenase was found to be more heat stable than peroxidase. Quality retention of processed vegetables was found to be highest in microwave blanched products. Results suggest that the use of peroxidase is to be continued as indicator enzyme, instead of lipoxygenase, as suggested by some recent research. Page(s): 1005-1009