NOPR Collection:

Synthesis of biologically important new 1, 4-benzothiazines bearing thiazole substituted aroyl moiety

Sat, 01 Mar 2003 00:00:00 GMT

Title: Synthesis of biologically important new 1, 4-benzothiazines bearing thiazole substituted aroyl moiety Authors: Ingle, R D; Bhingolikar, V E; Bondge, S P; Mane, R A Abstract: 2-Acyl-4-(2'-methyl/phenyl/nicotinyl-thiazol-4'-yl) phenols 1 have been obtained from the condensation of 2, 4-diacylphenol and thioamides in one pot using phenyl trimethyl ammonium tribromide(PTr). The compounds 1 are then converted to their respective esters 2 by condensing with aroyl chlorides. The esters 2 are then subjected to B.V. transformation to yield l-phenyl-3-[2'-hydroxy-5'-(2"-substitutedthiazol-4'-yl)]phenylpropane-1, 3-diones 3. These diones 3 and 2-aminobenzenethiol when allowed to react in DMSO afford the cyclocondensed products 2-[2'hydroxy-5'-(2" -substitutedthiazol-4" -yl)benzoyl]-3-(4'-substi tutedphenyl)-1, 4-benzothiazines 4. The structures of the new products 4 have been confirmed by elemental and spectral methods. The results of the microbial screening of the compounds are also recorded. Page(s): 695-698

Synthesis of new 4-aryl/alkyl-1-(5',5'-diphenyl-4'-oxo-1'-H-4',5'-dihydroimidazolidin- 2'-yl)-3-hydroxy-1,2,4-triazolidine-5-thione derivatives as potential anti-cancer agents

Sat, 01 Mar 2003 00:00:00 GMT

Title: Synthesis of new 4-aryl/alkyl-1-(5',5'-diphenyl-4'-oxo-1'-H-4',5'-dihydroimidazolidin- 2'-yl)-3-hydroxy-1,2,4-triazolidine-5-thione derivatives as potential anti-cancer agents Authors: Datar, Prasanna A; Shirodkar, P Y; Panikkar, K R Abstract: New 4-aryl/alkyl-1-(5',5'-diphenyl-4'-oxo-1'-H-4',5'-dihydroimidazolidin- 2'-yl)-3-hydroxy-1,2,4-triazolidine-5-thiones 3 have been prepared by the reaction of 2-carbethoxy-(5',5'-diphenyl-4'oxo-1' -H-4',5'-dihydroimidazolidin-2'-yl)-hydrazine 2 with various aryl/alkylisothiocyanates. Their anti-bacterial, anti-fungal, anthelmintic and anti-cancer activities are reported. Page(s): 690-694

Synthesis and antibacterial activity of pyrimido[4,5-b]quinolines

Sat, 01 Mar 2003 00:00:00 GMT

Title: Synthesis and antibacterial activity of pyrimido[4,5-b]quinolines Authors: Kumar, R Nandha; Suresh, T; Mohan, P S Abstract: A concise one-pot synthesis of pyrimido[4,5-b]quinolines 3a-e has been achieved from the potential substrates 2-chloro-3-formylquinolines 1 and guanidine nitrate 2. All the synthesized compounds have been biologically screened for their antibacterial activity. Page(s): 688-689

Synthesis of some benzothiazepins and their antimicrobial activities

Sat, 01 Mar 2003 00:00:00 GMT

Title: Synthesis of some benzothiazepins and their antimicrobial activities Authors: Shetgiri, N P; Nayak, B K Abstract: A series of 2-[(substitutedphenyl)-4-(substitutedphenyl)]-3,3-dihydro substituted-1 ,5-benzothiazepin 3 has been synthesized starting from acetophenones. The compounds are characterized and screened for their antimicrobial activities. Page(s): 683-687