http://nopr.niscpr.res.in/handle/123456789/23041 Fri, 09 Oct 2026 17:08:03 GMT 2026-10-09T17:08:03Z http://nopr.niscpr.res.in/handle/123456789/24509 Title: Pharmacological studies on the venomous spotted butterfish <span style="mso-bidi-font-style:italic">(<i>Scatophagus argus </i>Linn) sting extract on experimental animals </span> Authors: Muhuri, D; Karrnakar, S; Dasgupta, S C; Nagchaudhuri, K; Gomes, A Abstract: A sting of the fish <i style="mso-bidi-font-style: normal">S.</i> <i>argus, </i>a venomous edible spotted butterfish, produces tremendous local pain, severe swelling, rise of body temperature, throbbing sensation etc. To establish the pharmacological activities of <i style="mso-bidi-font-style:normal">S.</i> <i>argus </i>sting extract, the present investigation, was carried out on experimental animals. The LD₅₀ of extract was found to be 9.3 mg/kg (iv) in male albino mice. The extract showed loss of sensation, urination and salivation in mice. It potentiated pentobarbitone induced sleeping time in male albino mice and produced hypothermia. Extract produced a fall of cat and guinea pig blood pressure, which was completely abolished by rnepyramine. It produced a transient reduction of respiratory rate in rat, but decreased respiratory amplitude in cat, which was abolished after vagotomy. On isolated toad heart, the extract increased both the amplitude and rate of contraction. On isolated guinea pig heart, the sting extract decreased both the rate and amplitude of contraction leading to cardiac arrest, but it had no effect on isolated guinea pig auricle, The extract produced a reversible blockade of electrically induced twitch response of isolated chick biventer cervices preparation, but it had no effect on the isolated rat phrenic nerve diaphragm preparation. It produced a slow contractile response on isolated guinea pig ileum, rat uterus and rat fundal strip preparations but produced slow relaxation on isolated rat duodenum preparation. The contractile response Oil isolated guinea pig ileum and rat fundal strip was antagonised by SC 19220. It did not produce any significant cutaneous haernorrhage in mice and did not produce any haemolysis on saline washed erythrocytes. The sting extract significantly increased capillary permeability of guinea pig dorsal flank and produced oedema in mice hind paw. Page(s): 461-467 Sat, 01 May 2004 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/24509 2004-05-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/23448 Title: Characterization and identification of chitinase producing <i>Streptomyces venezuelae </i>P₁₀ Authors: Mukherjee, G; Sen, S K Abstract: In an attempt to isolate chitinase producers from soil, a streptomycete strain was found potent using natural chitin as the substrate. Chitinolytic activity was tested directly on agar plates, also with crude enzyme. Chitinase assay showed that the isolate could produce 0.8 U/ml<i> </i>of the enzyme. The morphological, cultural, physiological and biochemical characters of the isolate P₁₀ were studied, and identified as <i>Streptomyces venezuelae </i>P₁₀. Page(s): 541-544 Sat, 01 May 2004 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/23448 2004-05-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/23447 Title: Antioxidant and nitric oxide synthase activation properties of <i>Auricularia auricula</i> Authors: Acharya, Krishnendu; Samui, Krishnendu; Rai, Manjula; Dutta, Bani Brata; Acharya, Rupa Abstract: <i>In vitro </i>evaluation of antioxidant activities of <i>Auricularia auricula </i>showed significant inhibition of lipid peroxidation, and<i> </i>potent hydroxyl radical scavenging activity when compared with<i> </i>standard drug catechin. IC₅₀ value of crude, boiled and ethanolic<i> </i>extracts of <i>A. auricula </i>represented 403, 510, and 373 μg/ml<i> </i>respectively in case of hydroxyl radical scavenging activity and<i> </i>310, 572 and 398 μg/ml respectively in case of lipid peroxidation. Furthermore, crude, boiled and ethanolic extracts also increase significantly nitric oxide production (664, 191 and 850 pmole/mg dry wt/hr respectively) over the control. The present results revealed that <i>A. auricula </i>had potential therapeutic use. Page(s): 538-540 Sat, 01 May 2004 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/23447 2004-05-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/23446 Title: Expression of μ-Opioid receptors in developing rat spinal cord: An autoradiographic study Authors: Ray, Subrata Basu; Wadhwa, Shashi Abstract: The expression of μ-opioid receptors in the developing rat spinal cord (Postnatal days 7, 14, 30) was studied by autoradiography using [³H]DAMGO. When compared to camera lucida drawings, the receptor was noted over the entire gray matter and dorsal root ganglia at postnatal days 7 and 14. At postnatal day 30, the receptor expression decreased over the gray matter except the superficial laminae (laminae I and II). At all age groups studied, a higher expression of the receptor was noted over the superficial laminae. The study shows that μ-opioid receptors appears early in postnatal development and attains mature receptor distribution relatively late in ontogeny, suggesting a possible role in the normal development of nervous system. This is affirmed by an impairment of psychomotor development in babies born to mothers, addicted to opiates. Page(s): 533-537 Sat, 01 May 2004 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/23446 2004-05-01T00:00:00Z