NOPR Collection:

Effect of nimesulide co-administration on pharmacokinetics of lithium

Wed, 01 Dec 2004 00:00:00 GMT

Title: Effect of nimesulide co-administration on pharmacokinetics of lithium Authors: Sidhu, Shabir; Kondal, Amit; Malhotra, Samir; Garg, S K; Pandhi, P Abstract: In a crossover study, lithium was given orally at a dose of 56 mg/kg, prepared as suspension (0.5%) in carboxymethyl cellulose (CMC) and blood samples (l ml) collected after 0-24 hr after drug administration. After a washout period of two weeks, nimesulide (10mg/kg) was administered alongwith lithium (56 mg/kg) and blood samples were drawn at the same time intervals (0-24 hr) after drug administration. Plasma was separated and assayed for lithium by M 654 Na⁺/K⁺/Li⁺ analyzer and various pharmacokinetic parameters were calculated. C_max, Kel, t_1/2el and AUC_0-α of lithium were significantly increased when nimesulide was administered along with lithium as compared to control group. Page(s): 1248-1250

In vitro microtuberization in potato (Solanum tuberosum L.) cultivars

Wed, 01 Dec 2004 00:00:00 GMT

Title: In vitro microtuberization in potato (Solanum tuberosum L.) cultivars Authors: Sakha, B M; Bhatia, A K; Batra, V K; Chaudhary, V K; Batra, P; Khurana, S C Abstract: Mechanism of microtuberization in three elite cultivars kufri badhsha (KB), kufri chandramukhi (KCM) and kufri jawahar (KJ) of potato was studied. Sprouts of all the three cultivars were used to obtain in vitro shoot cultures. MS medium supplemented with chlorocholine chloride was found to be most suitable for all the cultivars. Maximum tuberization was obtained under incubation conditions of continuous darkness at 20°±1°C. The highest number of micro-tubers per plant basis was produced under continuous darkness and KCM recorded the highest yield of micro-tubers and was found significantly superior to KJ and KB. Page(s): 1245-1247

Conversion efficiency and nutrient digestibility of certain seaweed diets by laboratory reared Labeo rohita (Hamilton)

Wed, 01 Dec 2004 00:00:00 GMT

Title: Conversion efficiency and nutrient digestibility of certain seaweed diets by laboratory reared Labeo rohita (Hamilton) Authors: Bindu, M S; Sobha, V Abstract: Impact of three different types of seaweed diets on growth, feed utilization and nutrient digestibility of L. rohita was studied for 120 days. The seaweed diet fed fishes, especially Ulva based diet showed comparatively higher growth and weight increment. Good food conversion ratio, food assimilation efficiency, protein efficiency ratio and better nutrient digestibility were recorded for seaweed diet fed fishes. The results suggests the suitability of utilizing seaweeds, Ulva fasciata, Spyridia insignis and Sargassum wightii as partial substitute for fishmeal in formulated diets of L. rohita. Page(s): 1239-1244

In vitro explant culture of mantle epithelium of freshwater pearl mussel

Wed, 01 Dec 2004 00:00:00 GMT

Title: In vitro explant culture of mantle epithelium of freshwater pearl mussel Authors: Barik, S K; Jena, J K; Ram, K Janaki Abstract: The in vitro culture of nacre secreting pallial mantle explants of freshwater pearl producing mussel, Lamellidens marginalis (Lamarck) included depuration of pearl mussels with different physical and chemical agents to eradicate various commensals, removal of pallial mantle ribbon , aseptic preparation of explants from the ribbon and transfer of those explants into tissue culture petri dishes. Special synthetic tissue culture, media enriched with additives viz., inactivated calf fetal serum and antibiotics were poured into plates with explants. The culture plates were incubated at 30°C in a CO₂ incubator at 5% CO₂, The cultures could be maintained for 42-45 days without any contamination. After 12 hr epithelial like cells began to migrate out and formed a complete cell sheet surrounding the explant within 12-15 days. The epithelial cells in the culture indicated functional viability as subsequently after 38-40 days of culture, typical aragonitic 'nacre' crystals of CaCO₃ could be observed throughout the culture plates. Page(s): 1235-1238