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Synthesis and reactivity of 2-chloro-5-(4-phenyl-1H-1,2,3-triazol-1-yl) benzenamine

Mon, 01 Dec 2014 00:00:00 GMT

Title: Synthesis and reactivity of 2-chloro-5-(4-phenyl-1H-1,2,3-triazol-1-yl) benzenamine Authors: Sravya, G; Padmavathi, V; Padmaja, A Abstract: The nucleophilic reactivity of 2-chloro-5-(4-phenyl-1H-1,2,3-triazol-1-yl) benzenamine 5 was studied with different reagents under ultrasonication. Page(s): 1619-1625

An efficient improved synthesis of carvedilol, via 2-(2-methoxyphenoxy)ethyl 4-methylbenzenesulfonate intermediate

Mon, 01 Dec 2014 00:00:00 GMT

Title: An efficient improved synthesis of carvedilol, via 2-(2-methoxyphenoxy)ethyl 4-methylbenzenesulfonate intermediate Authors: Reddy, K Tatendra; Kumar, K Suneel; Omprakash, G; Dubey, P K Abstract: A facile synthesis of Carvedilol via a key 2-(2-methoxy-phenoxy)ethyl 4-methylbenzenesulfonate intermediate is described and this approach avoids the formation of bis side product (impurity-B) due to weak basic conditions and also operationally suitable for industrial application. Page(s): 1615-1618

Laser-induced, one-step synthesis of cyclodextrin carboxylic acids and their esters

Mon, 01 Dec 2014 00:00:00 GMT

Title: Laser-induced, one-step synthesis of cyclodextrin carboxylic acids and their esters Authors: Jankowski, Christopher K; Pelletier, Andre; Aychet, Nicolas; Hocquelet, Celine; Lacour, Jean-Luc; Bresson, Carole Abstract: α- and β-Cyclodextrin 6-azides (or 6A,6D-diazide) when subjected to laser irradiation followed by mild hydrolysis, lead, via the aldehyde, to small yields of corresponding acids, or in presence of alcohol to methyl or ethyl esters. The structures of compounds obtained have been identified using ESI mass and NMR spectroscopy. Page(s): 1611-1614

Carbodiimide mediated synthesis of some novel 4-thiazolidinones and 2,4-disubstituted thiazoles bearing N-methyl tetrahydrocarbazole moiety

Mon, 01 Dec 2014 00:00:00 GMT

Title: Carbodiimide mediated synthesis of some novel 4-thiazolidinones and 2,4-disubstituted thiazoles bearing N-methyl tetrahydrocarbazole moiety Authors: Gautam, Deepika; Chaudhary, R P Abstract: 2,3-Dihydro-1H-carbazol-4(9H)-one, obtained from oxidation of tetrahydrocarbazole with 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ), on reaction with N,N-dimethylformamide dimethyl acetal (DMF-DMA) affords 9-methyl-2,3-dihydro-1H-carbazol-4(9H)-one 3. The thiosemicarbazone derivative 4 of 9-methyl-2,3-dihydro-1H-carbazol-4(9H)-one on condensation with α-haloacids in presence of dicyclohexyl carbodiimide (DCC) furnish novel thiazolidin-4-ones 5 and on grinding with phenacyl bromides at room temperature produce new thiazole derivatives 6. The structure of all the synthesized compounds has been established by elemental analysis, IR, NMR and mass spectral data. X-Ray crystallographic studies of 2,3-dihydro-1H-carbazol-4(9H)-one 2 have been reported. Page(s): 1606-1610