http://nopr.niscpr.res.in/handle/123456789/54460 Sun, 11 Oct 2026 04:22:39 GMT 2026-10-11T04:22:39Z http://nopr.niscpr.res.in/handle/123456789/54473 Title: Clinico-Pathogenesis of COVID-19 in children Authors: Pandit, Kaveri; Gupta, Shalu; Sharma, Ankita Goel Abstract: The recent pandemic by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing Coronavirus disease-2019 (COVID-19) affects mainly adults and to a lesser extent children. The major route of spread is via droplets where the virus is released into the air in the form of droplets by an infected individual during coughing and sneezing. Virus primarily infects the respiratory tract epithelium. Its spike protein interacts via ACE-2 receptor and facilitates the entry of the virus into the cells by membrane fusion. The activated Cytotoxic T cells and other cells cause an exaggerated inflammatory response releasing huge amounts of pro-inflammatory cytokines like interleukins and interferon. Due to this surge in the cytokine levels leading to a storm like state, there is significant endothelial injury causing hyper-coaguable state and disseminated intravascular coagulation. The common presentation in children include involvement of respiratory system leading to pneumonia, severe pneumonia, acute respiratory distress syndrome and finally multiorgan involvement. Page(s): 264-269 Mon, 01 Jun 2020 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/54473 2020-06-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/54472 Title: Fluorescence quenching and measurement of captopril in pharmaceuticals Authors: Chen, Yahong; Chang, Weixiao; Zhu, Xue; Wang, Ruiyong; Tian, Fengshou Abstract: The mechanism of fluorescence quenching of the product S in the presence of captopril was studied. The maximum emission wavelength of the product S was at 405 nm with the excitation wavelength at 316 nm. It was found that the fluorescence quenching of product S was of a static one and the binding constant (K) was 9.29 × 106 J mol-1. A linear relationship was found between the relative fluorescence intensity of the product S-captopril system and the concentration of captopril. Under optimum conditions, the linear range of the calibration curve for captopril was 2~160 μg L-1 with a correlation coefficient of 0.9926 and a detection limit of 0.1 μg L-1. The relative standard deviation (RSD) was 3.60%. The analytical results of the pharmaceuticals obtained by this novel method agreed quite well with those obtained by the KIO3 titrimetry. Page(s): 270-276 Mon, 01 Jun 2020 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/54472 2020-06-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/54471 Title: Mineralization changes substituted type B carbonate of PO43− ion in the bone minerals of an archaeological sample studied using fourier self deconvolution technique Authors: Velraj, G; Karthikeyan, S; Chitra, A Abstract: The aim of this study was to describe the compositional changes in the archaeological specimen using FTIR. Fourier deconvolution was applied in the carbonate (500-650 cm−1), phosphate (900-1200 cm−1), and in the amide region (1700-1600 cm−1). The deconvolution of the spectra in the phosphate region 1200-900 cm−1 reveals six components 960 cm−1, 1010 cm−1, 1020 cm−1, 1030 cm−1, 1110 cm−1 and 1120 cm−1. The bone mineral such as CO32−, PO43− particle, collagen, and organic materials were studied in detail from the infrared spectra. The computed parameters such as collagen development, mineralization index, C/P proportion, crystalline index, and maturing of bone help us in characterizing the bone samples. The Low estimation of C/P proportion resulted in changes in Type B carbonate (PO43−) substitution. The absence of phosphate band ~1100 cm−1 and formation of β sheet structure were observed in the samples studied. Increased level of mineralization resulted in the increased in the crystalline nature of the bone samples. The study indicates the utilization of FTIR using self deconvolution technique which helps in understanding the compositional changes in the archaeological sample. Page(s): 277-282 Mon, 01 Jun 2020 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/54471 2020-06-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/54470 Title: Structural insights on Sucrose transport by Oryza sativa L. Sucrose/H+ Symporter1 (OsSUT1) through refined sequence - template alignment based structural modelling Authors: Syamaladevi, Divya P; Biswal, Bhagyashree Abstract: Sucrose/H+ Symporters (SUTs) play an important role in plant growth and yield. They are involved in long distance transport of sucrose from source leaves to filling grains of cereals through a process called phloem loading. However, the molecular mechanism of sucrose transport through SUTs is not yet known. Understanding the key residues involved in sucrose transport can be helpful in developing high yielding varieties through genetic engineering, gene editing or allele mining. Here, the molecular model of OsSUT1 developed based on refined target-template alignment using Modeller software provides structural insights on the sucrose transport mechanism. We propose 13 putative sucrose binding residues and 11 putative H+ binding residues involved in sucrose/H+ co-transport in OsSUT1. Page(s): 283-290 Mon, 01 Jun 2020 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/54470 2020-06-01T00:00:00Z