http://nopr.niscpr.res.in/handle/123456789/61521 Sun, 11 Oct 2026 00:19:22 GMT 2026-10-11T00:19:22Z http://nopr.niscpr.res.in/handle/123456789/61547 Title: Green synthesis of 5-methylpyridinium derivatives by C2-functionalization of pyridine-1-oxide derivatives and their antibacterial activity Authors: Dhadda, Surbhi; Goswami, Prakash G; Yadav, Kalpana; Guleria, Anjali; Jangid, Dinesh K; Khandelwal, Chandra L Abstract: An innovative green economic route has been developed for one pot multicomponent synthesis of 5-methylpyridinium derivatives by the reaction of 3-methylpyridine-1-oxide, aromatic aldehyde and β-ketoester catalysed by different ionic liquids (ILs), [BMIM][OH], [BMIM][Cl], [BMIM][Ac] in good to excellent yields. A relative study reinforced that [BMIM][OH] is the best IL for this C2-functionsalization reaction. The main highlights of this synthetic protocol are simple work-up, cost effectiveness and environmentally benign processing. The synthesized derivatives have been assessed for possible antibacterial activity against Staphylococcus aureus and Escherichia coli by using the microdilution method. The results of antibacterial activity suggests that compound 4I shows best antibacterial activity and other compounds show good to moderate activity. Page(s): 185-195 Wed, 01 Mar 2023 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/61547 2023-03-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/61546 Title: NiWO4 catalyzed expeditious synthesis of pyranopyrazoles Authors: Godinho, Mesira; Salgaonkar, Lalitprabha N; Anvekar, Tushar S; Vaz, Teotone; Kadam, Hari K Abstract: In this paper, a multicomponent green rapid method for synthesis of pyranopyrazoles is reported using NiWO4 in water in 15 min. Environment friendly features such as energy efficiency, aqueous medium, no hazardous solvent, no chromatography, in addition to the short reaction time, catalyst reusability and substrate tolerance without affecting yield proves the near perfectness of this method for synthesis of medicinally important pyranopyrazoles. NiWO4, ZnWO4 and CuWO4 have been synthesized using extract of plant Phyllantus amarus. The prepared catalysts have been characterized by XRD, EDX and SEM. Page(s): 196-201 Wed, 01 Mar 2023 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/61546 2023-03-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/61544 Title: Anti-inflammatory, analgesic and antitubercular activity of 4,6-diphenyl-4,5,6, 7-tetrahydro-3-selena-1,2,5-triazo-indene derivativesS Authors: Balasubramanian, S; Jayalakshmi, N Abstract: Several 4,6-diphenyl-4,5,6,7-tetrahydro-3-selena-1,2,5-triazo-indene derivatives have been synthesized by the Mannich reaction (condensation) of ethyl methyl ketone, substituted aldehyde and ammonium acetate and selenium dioxide. The chemical structures have been confirmed by means of IR, 1H NMR and mass spectral data. The synthesized compounds have been evaluated for anti-inflammatory, analgesic and antitubercular activity. The compounds have emerged as the most promising active compounds to that of standards. In addition, the inhibition effect increases with the increase in concentration of these compounds. Page(s): 202-206 Wed, 01 Mar 2023 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/61544 2023-03-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/61543 Title: A novel approach to determine anti-proliferative, anti-migratory and anti-microbial properties of 2-phenylethylammonium carboxylate molecular salts Authors: Akbaş, Hüseyin; Tayhan, Seçil Erden; Bilgin, Sema Abstract: 2-Phenylethylammonium (PEA) salt derivatives have been prepared between 2-phenylethylamine with various aromatic carboxylic acids (nicotinic, benzoic, salicylic, and γ-resorcylic) and confirmed by spectroscopic analyses. Additionally, the possible biological activities of these salts have been examined and the antiproliferative and antimigrative effects of salts on breast and colon cancer cell lines have been determined. Furthermore, to obtain preliminary data for the effects of the indicated compounds on cancer angiogenesis, in vitro migration analysis has been performed by human vascular endothelial cells. The antibacterial effects of the compounds have also been investigated. Therefore, an important contribution has been made to studies conducted to better recognize the pharmacological effects of salts. Page(s): 207-216 Wed, 01 Mar 2023 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/61543 2023-03-01T00:00:00Z