http://nopr.niscpr.res.in/handle/123456789/62359 Mon, 12 Oct 2026 22:28:46 GMT 2026-10-12T22:28:46Z http://nopr.niscpr.res.in/handle/123456789/62365 Title: Evaluation of Antioxidant and Anticancer Activity of Amino Acid Derived Schiff Bases and their Metal Complexes – A Review Authors: Ancy, Rayappan Paustina; Thilaga, Ganeshmurthy; Sanguni, Ganesmoorthy; Gowri, Maruthapillai Abstract: Simple condensation of an aldehyde or ketone with a primary amine, also known as an azomethine or an imine (-HC=N-) bond, forms Schiff bases. Amino acids are organic compounds comprising a single carbon atom, known as α -a carbon atom, along with an amino group (-NH2) and a carboxylic acid group(-COOH). Cancer leads to millions of deaths worldwide and is expected to increase by 12.8 percent in 2025 compared to 2020. Additionally, our body needs antioxidants to reduce harmful diseases, eliminate free radicals, and prevent oxidation. Schiff bases derived complexes tried to improve biological activity. A novel class of Schiff bases generated from amino acids and their metal complexes exhibits an enhanced broad spectrum of pharmacological actions. Their most significant medical applications include antibacterial, antifungal (including anti-yeast), antiviral, antitumor, anti-inflammatory, antipyretic, antimalarial, anticancer, antioxidant, and anesthetic properties. The finds of Schiff bases derived amino acids, and their complexes provide a range of activity rate that depends on their orientation and metal atom. They need to be exposed further to other biological studies. The review includes synthesizing, characterizing, and analyzing anticancer and antioxidant activity compounds. On critical evaluation, we established that these studies show some effect on therapy and lower the risk of diseases. Page(s): 437-447 Sat, 01 Jul 2023 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/62365 2023-07-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/62364 Title: Inhibitory activity of polyphenolic compound extracted from P. betel and T. aestivum with hepcidin for Iron deficiency anemia: An in silico approach Authors: Khan, Neha; Johri, Sonia; Paul, Nabomita Abstract: Anaemia is a condition that occurs when haemoglobin levels decrease below normal and a lower-than-normal number of healthy red blood cells are produced. A newly identified iron regulator, hepcidin reveals the body's iron status and demand for erythropoiesis to the intestine which modulates intestinal iron absorption. Hepcidin plays a significant role in the iron regulatory system as it naturally binds to ferroportin which is the cellular iron expoter. The hepcidin was docked with bioactive compounds in catechin, chlorogenic acid, T. aestivum grass and 2,4 dihydroxy benzaldehyde in P. betel leaves. The aim of the current study is to investigate the interaction of bioactive compounds with hepcidin through molecular docking. All three bioactive compounds revealed significant interaction with hepcidin. Catechin showed highest binding energy (7.1 Kcal/mol) as compared to cholorogenic acid and 2,4 dihydroxy benzaldehyde. Page(s): 448-454 Sat, 01 Jul 2023 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/62364 2023-07-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/62363 Title: Effect of co-expression of alpha-synuclein and leucine-rich repeat kinase 2 on the hallmark features of Parkinson’s disease in Drosophila melanogaster Authors: Jhonsa, Dimple; Devasani, Karan; Kaul, Rachna; Saraf, Madhusudan Page(s): 455-466 Sat, 01 Jul 2023 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/62363 2023-07-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/62362 Title: Down-regulation of miRNA 451a promotes many oncogenic signaling pathways in breast cancer patients Authors: Saeed, Hina; Ejaz, Samina Abstract: The present study was designed to investigate the expression status of the micro RNA 451a (miR-451a) in BC patients through multi-layered bioinformatics analysis. The miR-451a was down-regulated in BC patients and through the KEGG pathway analysis we were able to find 8 genes (CDKN2B, CDKN2D, ATF2, EIF2A3K, RAB5A, CAV1, UCK1, and PMM2) encoded molecules of which can potentially participate in different pathways like cell cycle, FOXO signaling pathway, influenza A, Viral carcinogenesis, Endocytosis, HTLV-I infection, Metabolic pathways, and ubiquitination pathways. While PSMB8 acts as the major target of miR-451a and is involved in different pathways of cancer proliferation, metastasis, and growth. The PSMB8 protein is a component of the immuno-proteasome and participates in the ubiquitination-based degradation of the proteins. It’s concluded that miR-451a acts as a tumor suppressor molecule and its down-regulation turns on many oncogenic pathways and thus promotes cancer. Page(s): 467-477 Sat, 01 Jul 2023 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/62362 2023-07-01T00:00:00Z