http://nopr.niscpr.res.in/handle/123456789/63027 Sat, 10 Oct 2026 23:51:08 GMT 2026-10-10T23:51:08Z https://http://nopr.niscpr.res.in:443/retrieve/190670/Cover.png http://nopr.niscpr.res.in/handle/123456789/63027 http://nopr.niscpr.res.in/handle/123456789/63053 Title: Ethnonutritional, ethnomedicinal and sacred religious rites of ―Karkidaka charya‖ a traditional seasonal practice of Kerala Authors: G, Raghi R; Rao, Krishna; S, Indu Abstract: Karkidaka charya is the seasonal regimen followed during Karkidaka, the last month of the Malayalam calendar (mid-July to mid-August). It is the month with torrential rain, low digestive fire and causing the vitiation of three humours (Vata, Pitta and Kapha) according to Ayurveda classics. Economic imbalances of the early farming communities, low immunity and environment which is favourable for epidemics, made the month of Karkidaka more vulnerable. Hence, our older generation followed a strict regimen to avert from this detrimental Karkidaka. The present study is a compilation of the traditional practices in Kerala during the month of Karkidaka and its critical analysis. About 22 unique practices were observed in different parts of Kerala during this month. Most of the practices were observed as a caution for upcoming pandemic in the severe rainy month. The practices cover ethnonutritional, ethnomedicinal and sacred religious aspects of Karkidaka charya. Page(s): 693-707 Fri, 01 Dec 2023 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/63053 2023-12-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/63052 Title: Majun-e-Suranjan and Habb-e-Azraqi are two Unani compound drugs that are effective and safe in cases of gout - An initial study Authors: Verma, Radhey Shyam; Afridi, Rifat; Rehman, Shagufta; Ayub, Sadia; Qayyum, Zoha; Singh, Ravendra; Afza, Sheereen; Akhtar, Jamal; Khan, Asim Ali Abstract: Present study evaluated the therapeutic efficacy and safety of two Unani compound drugs Majun-e-Suranjan and Habb-e-Azraqi in cases of gout on modern scientific parameters viz., clinical, biochemical and haematological. This work was conducted at Regional Research Institute of Unani Medicine (RRIUM), Aligarh, during 2014-2019. 71 people were chosen from the pool of patients visiting the outpatient department (OPD). Patients received the Unani medicines Majun-e-Suranjan in a dose of 5.0 g and Habb-e-Azraqi in a dose of 1 pill (250 mg) twice daily after meals for a period of 56-days. One-way analysis of variance (ANOVA) was used for the analysis of data, and the statistical significance of the findings was determined by Dennett's test. The study reveals that the two Unani medicines are safe, non-toxic, and significantly relieve the symptoms of gouty arthritis. It is suggested to conduct more research among a large population. Page(s): 708-716 Fri, 01 Dec 2023 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/63052 2023-12-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/63051 Title: IoT based Siddha diagnosis for human health monitoring Authors: A, Yazhini; K, Saravanan Abstract: In Siddha, the process of diagnosis is completely related to physical and clinical metrics of the human body. The art of diagnosing and the prognosis are conveyed by the siddhars by using silk or twine thread, which is an ancient technique followed till now to diagnose diseases in human. This paper proposes an IoT based automated device to detect the disease using siddha methodologies. The aim is to design a novel non-invasive device to identify human health problems using the carpus (wrist) circummetric sign. This device is developed and integrated on the basis of IoT platform for real time usage. It determines the wrist circummetric sign, condition of person health to be measured automatically using IR sensor, color sensor, actuators. Here, we inbuilt the embedded IoT system for validating the accurate results for better performance and display the output results in mobile through MQTT dashboard. This developed human health monitoring device can be used for diagnosing human physiological based parameters related to siddha which is termed as Manikadainool. Results proved that this device can predict the wrist parameters for Manikadainool in accurate and efficient manner. Page(s): 717-726 Fri, 01 Dec 2023 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/63051 2023-12-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/63050 Title: Preclinical pharmacokinetics and herb-drug interaction studies of atorvastatin co-administered with the herbal slimming products Authors: Husain, Athar; Reza, Mohammad Irshad; Dagde, Shailesh D; Ahmed, Syed Anees; Singh, Pragati; Verma, Saurabh; Katekar, Roshan; Kumar, Ashish; Gayen, Jiaur R Abstract: Herbal slimming products (HSPs) contain multiple herbs used in weight loss. Phytoconstituents of several plant extracts show the inhibitory effects on the drug-metabolizing enzymes causing interaction when taken with other drugs. Atorvastatin (ATS) is used in the treatment of hyperlipidemia. This study aimed to investigate the effect of HSPs on the pharmacokinetics and pharmacodynamics of ATS. ATS (10 mg/Kg) was administered alone or in combination with HSP1 (200 mg/Kg)/ HSP2 (165 mg/Kg) orally in the SD rats for pharmacokinetics study. Hyperlipidemia was induced in Golden Syrian Hamster by feeding HFD (60% kcal). Furthermore, biochemical levels in serum, ROS, gene expression and lipid accumulation levels were examined in hamster liver tissue. HSPs have significantly enhanced the permeability and inhibited the metabolism of ATS by inhibiting the CYP3A4 isoenzyme confirmed by in vitro assay. Co-administration of HSPs with ATS enhanced the relative bioavailability of ATS.Concomitant administration of HSPs with ATS has significantly reduced the fat content, inflammatory cytokines, TG, VLDL, LDL levels, tissue MDA level, HMGCR and SREBP1c mRNA expression levels, lipid accumulation as well as collagen content and has increased the serum HDL level as well as tissue SOD, CAT, GHS and mRNA expression levels of LXRα and CYP7A1. The aforementioned outcomes indicated that co-administration of HSPs with ATS may lead to herb-drug interaction. Therefore, precaution should be taken and dose adjustment is required when administered simultaneously. Page(s): 727-738 Fri, 01 Dec 2023 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/63050 2023-12-01T00:00:00Z