NOPR Collection:

Synthesis of chemiluminescent biotinyl naphtho[1,8-de][1,2]diazepine-1,4-diones

Wed, 01 Nov 2006 00:00:00 GMT

Title: Synthesis of chemiluminescent biotinyl naphtho[1,8-de][1,2]diazepine-1,4-diones Authors: Murthy, N V Krishna; Reddy, A Ram Abstract: A new chemiluminescent seven membered cyclic peri hydrazide, 6-amino-2,3-dihydronaphtho[1,8-de][1,2]diazepine- 1,4-dione (AH, 4), and five of its biotin conjugates with various spacer groups are synthesized. The total framework of the chemiluminescent biotin conjugates is constructed taking advantage of a convergent synthesis from various stable intermediates employing DCC condensation and NHS activation. Geometry optimization studies show that the conjugates exist in an enveloped conformation. AH exhibits chemiluminescence properties analogous to luminal. The chemiluminescence of hydrazide is enhanced when it is directly conjugated to biotin through an amide linkage while via spacers its efficiency decreased. Page(s): 2512-2522

The theoretical conformation analyses of polyoxanorbornene chain

Wed, 01 Nov 2006 00:00:00 GMT

Title: The theoretical conformation analyses of polyoxanorbornene chain Authors: Yilrnaz, Sevil Savaskan; Abbasoglu, Riza Abstract: The conformational analysis of polyoxanorbornene (PONB) chain is investigated with the AM1, MM2, AMBER and OPLS methods taking into consideration the possibility of binding of oxanorbornene monomers to each other at various positions. i.e. exo-exo, exo-endo, endo-endo. The chain that is formed by connecting exo-endo positions of the monomers has lower torsional barrier energy than those formed with bonds at other positions and has more flexibility. It is determined that thredisyndiotactic chain formed by exo-endo addition has coil shape. Disyndiotactic chain formed by connecting oxanorbornene monomers in mixed type has a linear structure. It is found that the repeat unit conformations of thredisyndiotatic and disyndiotactic chains of PONB are TGTG and (TGTG)₂, respectively. Page(s): 2491-2496

Correlation between the pKa and pharmacological properties of some imidazolin-5(4H)-ones, their precursors and Schiff’s bases

Wed, 01 Nov 2006 00:00:00 GMT

Title: Correlation between the pKa and pharmacological properties of some imidazolin-5(4H)-ones, their precursors and Schiff’s bases Authors: Gupta, J K; De, Biplab; Saravanan, V S Abstract: The pKa value of some synthesized imidazolin-5(4H)-ones and their precursors, Schiff’s bases are determined by potentiometric method and the analgesic activity and CNS depressant property are evaluated, which are correlated with the pKa values. It is found that a correlation established in best fit curve of 3^rd order polynomial equation. Page(s): 2580-2582

Isolation of chalkones from the seeds of Psoralea corylifolia Linn.

Wed, 01 Nov 2006 00:00:00 GMT

Title: Isolation of chalkones from the seeds of Psoralea corylifolia Linn. Authors: Agarwal, Deepshikha; Garg, S P; Sah, Pramilla Abstract: Isolation and characterization of a new chalkone namely 4,2'-dihydroxy-2''-(1'''-methyl ethyl)-2''-3''-dihydro-(4'',5'',3',4') furano chalkone 1 along with a known chalkone 4,2'-dihydroxy-4'-methoxy-5'-(3''', 3'''-dimethyl allyl)-chalkone 2 have been carried out from the seeds of the desert variety of Psoralea corylifolia Linn on the basis of spectral data analysis i.e. IR, ¹H NMR, mass and chemical reactions. Page(s): 2574-2579