NOPR Collection:

Investigation of spectroscopic, water barrier and thermal characteristics of ameliorated chitosan membrane

Sun, 01 Sep 2024 00:00:00 GMT

Title: Investigation of spectroscopic, water barrier and thermal characteristics of ameliorated chitosan membrane Authors: Kumar, Shivam; Sachdev, Devyanshu; Sharma, Renu; Bhullar, Navneet Kaur Abstract: The present research focuses on the ameliorated chitosan membrane (ACM) in which chitosan based membrane has been developed by optimization of different synthesis parameters such as the amount of solvent, amount of monomer and amount of initiator in which maximum percentage grafting of 812% is achieved. The synthesized membrane is further investigated for the evaluation of spectroscopic, water barrier and thermal characteristics. The spectroscopic studies are carried out using FTIR spectroscopy and UV-visible-NIR absorption spectroscopy which is used for evaluating the chemical characteristics. Water barrier characteristics are evaluated using a water absorption test and water contact angle in which water absorption of 1175% in 180 min and water contact angle of 77.59° indicating a hydrophilic nature whereas the thermal characteristics are evaluated using TGA and DSC studies which confirmed the thermal stability of 22.92% at 800°C. Page(s): 673-680

Development and evaluation of gelatin/polyacrylamide/carboxymethyl tamarind kernel gum hydrogel for delivery of ampicillin sodium

Sun, 01 Sep 2024 00:00:00 GMT

Title: Development and evaluation of gelatin/polyacrylamide/carboxymethyl tamarind kernel gum hydrogel for delivery of ampicillin sodium Authors: Kumari, Tanuja; Nitin; Meena, Priyanka; Warkar, Sudhir G. Abstract: Gelatin-based hydrogels, despite their excellent biocompatibility, face limitations in their utility for targeted drug release due to low mechanical strength. Thus, this research is directed towards the fabrication of pH-responsive hydrogels based on gelatin, polyacrylamide (PAM) and carboxymethyl tamarind kernel gum (CMTKG), followed by their loading with ampicillin sodium drug. The hydrogel has been optimized by varying crosslinker, and initiator amounts to observe their effect on swelling. The swelling is increased with an increase ininitiator, reaching a maximum of 1371% at pH 7.4 and 1218% at pH 1.2. The hydrogels are analyzed through Scanning Electron Microscopy (SEM), Powder X-ray Diffraction (PXRD), and Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy (ATR-FTIR) techniques. Various parameters such as drug loading, porosity, and gel fraction are evaluated. The in vitro drug release is evaluated in both pH 1.2 and 7.4 buffer, with higher drug release (63.3%) observed under alkaline pH. The kinetic modeling data validates the Korsmeyer-Peppas model (R2= 0.9871) to be the suitable model for the explanation of the drug release mechanism, suggesting the Fickian diffusion (n<0.5, pH 1.2) and non-Fickian diffusion (n>0.5, pH 7.4). Therefore, the Gelatin/PAM/CMTKG hydrogel shows potential for targeted release of ampicillin sodium in response to varying pH. Page(s): 681-690

Spectrophotometric quantification of biotin in drug formulations utilizing Pd(II) promoted ligand substitution approach in micellar medium

Sun, 01 Sep 2024 00:00:00 GMT

Title: Spectrophotometric quantification of biotin in drug formulations utilizing Pd(II) promoted ligand substitution approach in micellar medium Authors: Srivastava, Abhishek; Srivastava, Neetu; Singh, Vinay Kumar Abstract: A spectrophotometric approach that is straightforward, efficient, highly sensitive, and precise has been devised for quantifying biotin in both its pure state and pharmaceutical samples. Analysis of biotin in biological and pharmaceutical samples is essential for therapeutic evaluation and patient follow-up bioavailability. Several methods for determining this drug have drawbacks including specialized equipment that many quality control laboratories and universities in developing countries lack. The methodology relies on the inhibitory approach of biotin on the Pd(II) promoted ligand substitution (LS) reaction involving phenylhydrazine (PHZ) and hexacyanoferrate(II). The process entails replacing cyanide in [Fe(CN)6]4- with PHZ, triggering the development of a complex [Fe(CN)5PHZ]3-. The complex demonstrates a significant level of absorption at a specific wavelength of 488 nm. The established limit of detection for biotin is 0.117 μg mL−1. Experiments on recovery are conducted to confirm the precision and accuracy of biotin quantification. The suggested approach has been effectively utilized for the examination of biotin in pristine samples and various medications, demonstrating remarkable levels of precision and accuracy. The outcomes show good agreement when compared to the findings of the official analytical method. The excipients typically employed in medicines do not exhibit any interference with the suggested methodology. This methodology is highly effective for accurately determining trace levels of different drugs and biological molecules that can significantly impede the catalytic efficiency of Pd(II). Page(s): 691-701

Efficacy improvement technique of air-filtration unit affected by biofouling using electroless Ni-Cu-P coating

Sun, 01 Sep 2024 00:00:00 GMT

Title: Efficacy improvement technique of air-filtration unit affected by biofouling using electroless Ni-Cu-P coating Authors: Ghosh, Niloy; De, Jhumpa; Chowdhury, Amit Roy Abstract: Moisture from ar is often responsible for biofouling and corrosion on the inner walls of the air filtration system and there by affecting the bacteria colony forming units (CFU Count). This phenomenon is more prevalent in humid environment. Applying electroless Nickel-Copper-Phosphorous (Ni-Cu-P) coating on mild steel helps to prevent bio fouling. An air filtration unit with inner walls coated with nano-TiO2 and inlet filter mesh made of Luffa and coated activated charcoal and zeolite is used in the experimentation process. The inner chamber is also radiated by band C of Ultraviolet sources (UVC) with 254 nm wavelength. A sudden spike in bacteria colony count has been observed as the air filtration unit remains in off mode for prolonged duration of time. The efficacy of the air filtration unit upon remaining in off- mode for a long time has been determined in the present work considering the bacterial colony count as response. Electroless Ni-Cu-P coating has been applied at selected locations previously affected by biofouling. A predictive model has been developed following response surface methodology using bacterial colony count as response and the composition of the electroless coating bath as the process parameters. Genetic algorithm was applied for the determination of the best possible constitution of chemical coating bath for the minimization of the bacterial colony count. Bacteria Colony formation was significantly affected by the sources of Nickel ion, Copper ion and the concentration of reducing agent in the electroless Ni-Cu-P coating bath. The confirmation run showed that the observed CFU count at the optimum condition converges with the data obtained from Genetic Algorithm. Page(s): 702-709