http://nopr.niscpr.res.in/handle/123456789/65444 Sat, 10 Oct 2026 20:31:23 GMT 2026-10-10T20:31:23Z http://nopr.niscpr.res.in/handle/123456789/65454 Title: The influence of quantitative alterations of steroid hormones on energy metabolism of prostate tumors Authors: Alibegashvili, Manana; Ramishvili, Liana; Mikaia, Nino; Chigogidze, Teimuraz; Gabunia, Nino; Sepiashvili, Bela; Nakashidze, Irina; Gordeziani, Manana; Ahmad, Sarfraz; Kotrikadze, Nanuli Abstract: Quantitative changes of steroid hormones in prostate tumor tissues and their influence on energy metabolism represents a critical factor in cancer progression and development of hormone-resistant malignant tumor. All distinguishing features of cancer must be one way or other related to specific metabolism that is characteristic to tumor cells. The aim of the work was to study the influence of the alterations in steroid hormone levels on key processes of energy metabolism in the tumor tissues of men with prostate tumors. Based on the data obtained from our research, it can be concluded that: i) A significant change in the amount of steroid hormones in tumor tissue of men with prostate adenocarcinoma have a considerable influence on the unique metabolic mechanisms characteristic to prostate cancer which contributes to the progression and aggressiveness of the tumor; and ii) A significant alteration in energy metabolism of prostate cancer was also established, which revealed through the activation of oxidative phosphorylation in case of benign tumor. It can therefore be implicated that in parallel to the progression of the disease, malignant prostate cells switch again to the increased glycolysis (activation of glycolytic pathway). Page(s): 349-354 Tue, 01 Apr 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/65454 2025-04-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/65453 Title: Evaluation of Tagetes Erecta (Marigold) Extract (MaQxan™ (20:2)) potency in induced learning and memory deficit by modulating neurotransmission and synaptic plasticity Authors: Anzar, Cheppattu Mohammed Abdullah; Joseph, Molath Varkey; Sundaram, Ramachandran; Vadiraj, Bharadwaj Gururaj; Prasad, Padmanabhan Chettayil; Earanimose, Bineesh Abstract: The ancient Indian medical system, Ayurveda, has identified numerous plants with antioxidant properties as beneficial for treating neurological diseases. The active ingredients in herbal plants are utilized to modulate synaptic plasticity and neurodegenerative disorders. Different strategies are used to treat neuronal diseases and their secondary consequences by modifying synaptic plasticity. Because herbal remedies are inexpensive and have fewer adverse effects, they are advantageous. The main strategies for achieving this were to study the phases of in vivo Tagetes Erecta (Marigold) Extract (MaQxanTM (20:2) administration in rats and, secondly, to study the potency of gene expression alteration on BDNF, TrkB, CREB, CAMKII, NMDA-R, nAChR, mGluR, and MAPK genes in the hippocampus. This study demonstrated that Tagetes Erecta (Marigold) Extract (MaQxanTM (20:2) at medium and high doses (10 mg/kg to 20 mg/kg) modulated the genes for BDNF, TrKB, CAMKII, NMDA-R, nAChR, mGluR, and MAP-K, showing neurotransmitter and synaptic plasticity control efficacy in animal models. Our study advances knowledge of the effects of Tagetes erecta (Marigold) extract (MaQxanTM (20:2)) on the central nervous system. Our results reveal that MaQxanTM (20:2) significantly enhances memory retention and synaptic plasticity while maintaining neuronal integrity. Hence, the synaptic plasticity improvement shown by MaQxanTM (20:2) can be attributed to the expression of plasticity-related proteins within the hippocampus, indicating its potential as a novel intervention for enhancing neurotransmission and cognitive function. These findings suggest that MaQxanTM (20:2) may serve as an effective therapeutic strategy for improving synaptic plasticity and alleviating depression and stress-related cognitive deficits. Page(s): 355-362 Tue, 01 Apr 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/65453 2025-04-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/65452 Title: Green Synthesis of Nickel Oxide Nanoparticles using Vitex negundo Leaf for Antibacterial and Anti-inflammatory Activities Authors: Aseen, A Hajeera; Jyolsna, P; Gowthami, V; Anbarasu, M; Vivek, P Abstract: This study addresses the crucial need for an environmentally sustainable method by synthesizing Nickel Oxide nanoparticles (NiO NPs) by using Vitex negundo(VN) leaf extract as a natural stabilizing and reducing agent. As the demand for green nanoparticle synthesis continues to increase and innovative approaches are essential to reduce reliance on harmful chemicals and high energy consumption. The synthesis of NiO NPs process was carried out at room temperature, followed by annealing at 500°C and 700°C to enhance the nanoparticles' properties respectively. X-ray diffraction (XRD) analysis revealed improved crystallinity at higher temperatures, with crystalline sizes of 20.91 nm at 500°C and 32.61 nm at 700°C. These findings underscore the potential of using plant extracts of green synthesis, offering a sustainable pathway for producing high-quality nanoparticles and contributing to the advancement of eco-friendly nanotechnology. The UV-Vis spectrum showed an energy band gap of 3.38 eV. SEM analysis revealed spherical particles with some agglomeration, while EDX confirmed the elemental composition. FTIR analysis identified functional groups in the sample annealed at 500°C. Antibacterial testing using the agar well diffusion method demonstrated activity against B. subtilis, S. aureus, E. coli, and P. aeruginosa. Additionally, the nanoparticles exhibited significant anti-inflammatory activity, highlighting their potential for biomedical applications. Page(s): 363-371 Tue, 01 Apr 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/65452 2025-04-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/65451 Title: Exploration of phytochemical compounds from Millets as NRF2 activators using molecular docking and molecular dynamics simulation approaches Authors: Nasiruddin, Nalban; Wanjari, Manish; Matte, Sudhir; Kumar, Anurag; Bagde, Vaidehi; Tamboli, Munaf; Jamadagni, Pallavi Abstract: Oxidative stress plays vital role in progression of several diseases like cardiovascular, neurological and gastrointestinal disorders. Millets, on regular consumption, are known to have beneficial effects. They are also rich in phytochemicals. In the current study, these phytochemicals are aimed against the complex of KEAP1-NRF2 and activating NRF-2 which is a potent inducer of anti-oxidant enzymes like heme-oxygenase and superoxide dismutase. Molecular docking was conducted to study compounds that can form an interaction similar to 1VX (co-crystalized ligand). CDOCKER interaction energies of isovitexin, vitexin, kaempferol, protocatechuic acid, and vanillic acid were better than 1VX. The best three molecules- isovitexin, vitexin and kaempferol, based ontheir CDOCKER interaction energy, were subjected to molecular dynamic simulation for 100 ns which revealed their stability at active site. Further MM-PBSA binding free energy of phytochemicals was calculated. Values of isovitexin, vitexin, kaempferol and 1VX are -32.04 Kcal/mol, -24.81Kcal/mol. -4.17 Kcal/mol, and -10.25 Kcal/mol, respectively, which indicate high degree of binding compared to cocrystallized ligand 1VX. Results indicated that selected compounds- isovitexin, vitexin, kaempferol can act as NRF2 activators which further can be confirmed through in vitro and in vivo studies. Page(s): 372-380 Tue, 01 Apr 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/65451 2025-04-01T00:00:00Z