http://nopr.niscpr.res.in/handle/123456789/65887 Sat, 10 Oct 2026 13:42:57 GMT 2026-10-10T13:42:57Z http://nopr.niscpr.res.in/handle/123456789/65896 Title: Synthesis, spectral, molecular docking and antimicrobial studies of some substituted 4-([1,1′-biphenyl]-4-yl) pyrimidine-2(1H)-thiones Authors: Venkatraman, R; Divya, J; Gayathri, P; Muthuvel, I; Thirunarayanan, G Abstract: Some substituted 4-([1,1′-biphenyl]-4-yl)pyrimidine-2(1H)-thione derivatives were synthesized by one-pot three-component synthesis reaction of 4-acetyl biphenyl, various substituted aryl aldehydes and thiourea in the presence of sodium hydroxide. In this reaction, the yield was more than 85%. The synthesized pyrimidine thiones were characterise by their physical constants, micro-analysis and spectroscopic data. The molecular docking study of these pyrimidinethiones was investigated with protein interaction-affinity measurements. Using the Bauer-Kirby technique, the antimicrobial abilities of synthesized pyrimidinethiones were evaluated. Page(s): 465-475 Thu, 01 May 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/65896 2025-05-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/65895 Title: Effect of temperature and solvents on thermo-physical properties of pyrimidine substituted thiazolidinone derivatives at three different temperatures Authors: Mehta, Umang P; Godhani, Dinesh R; Saiyad, Anwar H; Parmar, Kuldip P; Mehta, Jignasu P Abstract: Ultrasonic velocities, densities, and viscosities have been determined in a binary liquid tandem including pyrimidine substituted thiazolidinone at temperatures T= (298.15, 308.15, and 313.15 K) over the thiazolidinone's complete molality range. 5-(4-fluorobenzylidene)-2-(furan-2-yl)-3-(pyrimidin-2-yl)thiazolidin-4-one (AZ1) and 2-(furan-2-yl)-5-(4- methylbenzylidene)-3-(pyrimidin-2-yl)thiazolidin-4-one (AZ2) in N,N-dimethyl formamide (DMF) and dimethylsulfoxide (DMSO) were studied. Further to various acoustical and thermodynamic parameters, measurements have been made of the density, viscosity, and ultrasonic sound velocity. Further study has been conducted to figure out the effects of solvent alterations and structural modifications on the values of Gibbs energy of activation (ΔG*), enthalpy of activation (ΔH*), and entropy of activation (ΔS*). These results have been explained in terms of the molecular interactions among the constituents of the liquid mixture. Page(s): 476-485 Thu, 01 May 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/65895 2025-05-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/65894 Title: Impact of CPC micellar medium on Ru(III) promoted oxidation of L-Valine by diperiodatocuprate(III) Authors: Srivastava, Abhishek; Srivastava, Neetu; Singh, Ruchi Abstract: The objective of the proposed investigation is to examine the influence of cationic surfactant on the Ru(III) facilitated LValine oxidation using diperiodatocuprate(III) (DPC) in an alkaline medium. The oxidation rate was ascertained by measuring the decrease in absorbance at a wavelength of 415 nm, an indicator of the Cu(III) concentration. The reaction's advancement was assessed employing the pseudo-first-order condition as a gauge for [OH–], [DPC], ionic strength, [LValine], [Ru(III)], [IO4 –], [Surfactant], and temperature. L-Valine and DPC interact stoichiometrically in a ratio of 1:4. Across the spectrum of concentrations examined, the reported reaction reflects less than unit order kinematics in relation to both [L-Valine], and [OH–], first-order reliance on the [DPC] and [Ru(III)], and negative fractional-order for [IO4 –]. A zero salt effect is suggested by the observed constancy in oxidation rate with the inclusion of electrolytes. The oxidation rate is significantly enhanced by Ru(III) solution (as a catalyst) at ppm concentration. Cetylpyridinium chloride (CPC) micellar media facilitates an additional enhancement in the rate of the desired reaction. CPC thus exhibits an excellent compatibility with Ru(III) for the L-Valine oxidation using (DPC). Page(s): 486-495 Thu, 01 May 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/65894 2025-05-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/65893 Title: Synthesis, characterization and biological activity of metal complexes and their Schiff base ligands Authors: Charitha, K Ramya; Kavitha, P Abstract: Schiff base ligands have been chemically synthesized from 6-aminopyrimidine-4-thiol and 4-formyl-2-hydroxybenzonitrile in a 2:1 stoichiometric ratio (2L:M) along with their corresponding Cu(II) and Zn(II) complexes. Thermo gravimetric analysis, 1H and 13C NMR, FT-IR, UV-Visible and MS spectroscopic techniques have been used to analyze the structures of all the synthesized substances. Additionally, the antibacterial activity of the ligands (L) and their metal complexes has been examined in vitro against several pathogens. Comparing the activity to the MIC and zone of inhibition allows for a quantitative and qualitative evaluation. Research has shown that metal (II) complexes are more effective than ciprofloxacin against selected microbes. Page(s): 496-499 Thu, 01 May 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/65893 2025-05-01T00:00:00Z