http://nopr.niscpr.res.in/handle/123456789/66480 Sat, 10 Oct 2026 02:36:59 GMT 2026-10-10T02:36:59Z http://nopr.niscpr.res.in/handle/123456789/66512 Title: Synthesis, characterization and antimicrobial activity of pyrazole derivatives Authors: Anusha Rechel, Polepaka; Jyothi, Sunkari Abstract: This study synthesized pyrazole derivatives from pyrazoline and evaluated them for antibacterial activity. From benzofuran- 5-carbaldehyde and 1-(1,2,3,4-thiatriazol-5-yl)hydrazine, compound 1 is formed under reflux. Then DMF and POCl3 is added at 70°C for 5 h to the compound 1 to get compound 2. To a mixture of compound 2, acetophenone in ethanol and KOH is added and stirred under reflux for 6 h to get compound 3. From the compound 3, different pyrazole derivatives have been synthesized. All the desired compounds have been successfully synthesized and characterized by 1H and 13C NMR and LCMS. The antimicrobial activity has been tested using a serial dilution approach against several Gram-positive and Gram-negative bacteria. Compounds 1, 3, 5, 6, 8 and 9 show greater antimicrobial activity against several Gram-positive and Gram-negative bacteria. Page(s): 859-863 Mon, 01 Sep 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/66512 2025-09-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/66511 Title: Interaction between cationic and anionic surfactant using ultrasonic, physical and adiabatic parameters Authors: Gupta, Aditya; Saxena, Indu; Mishra, Divyanshi; Yadav, Preeti Abstract: Surfactants are organic amphiphilic molecules having hydrophilic and hydrophobic parts in the same molecule. The relative densities, relative viscosities, specific conductance and ultrasonic velocity of sound of binary solutions of SDSCTAB in water, formed in different mole fraction ratios, have been measured at 298 K and 308 K. From these data, the physical parameters such as adiabatic compressibility (βad), intermolecular free length (Lf), acoustic impedance (Z), relaxation time (τ) and molar free volume (Vf) have been evaluated using standard relations. The results are thus interpreted in terms of molecular interactions between cationic and anionic surfactants. Investigated value of physical properties thus defines that the molecular interaction is feasible and associative in nature and the determined acoustical and adiabatic parameters supports that nature. Page(s): 864-870 Mon, 01 Sep 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/66511 2025-09-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/66510 Title: New Schiff base and potent antimalarial, antioxidant, antidiabetic ternary complexes Authors: Ragole, Vikas; Wankhede, Dnyaneshwar; Biradar, Yogesh; Deshmukh, Pradeep; Gayakwad, Sonaji; Butle, Santosh Abstract: Potent antimalarial, antioxidant and antidiabetic ternary complexes have been obtained by RT reaction of Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) chlorides with new Schiff base (E)-2-((benzo[d]thiazol-2-ylimino) methyl)-4-nitrophenol (S3) and 8-hydroxyquinoline (8-HQ) in equimolar amounts. The SB (S3) is derived by reacting 2-hydroxy-5-nitrobenzaldehyde with 2-aminobenzothiazole using catalytic glacial acetic acid in an ethanolic medium. The compounds have been structurally analysed using elemental analysis, IR, electronic spectra, TGA-DTA and powder XRD (PXRD) analysis, magnetic and molar conductance measurements. All compounds have been screened for antimicrobial, antidiabetic, antioxidant, antimalarial and anticancer activities, and exhibited future potential for use against these. Molecular docking studies of all the ternary complexes have been conducted against multiple receptors viz., glucose oxidase, endonuclease, D-alanine ligase, oxidoreductase inhibitor, hydrolase and squalene epoxidase. The obtained results have been assessed in terms of binding affinities. Page(s): 871-880 Mon, 01 Sep 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/66510 2025-09-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/66509 Title: Synthesis and physicochemical analysis of bimetalphthaltocyanine pigment based on bivalent metals Authors: F Dzh, Mirzaeva; Kh Kh, Turaev; I A, Umbarov; A T, Dzhalilov; J B, Fayziev; A K, Nomozov Abstract: In this paper, the research on the synthesis of magnesium-zinc-phthalocyanine pigment has been carried out. It has been synthesized based on phthalic anhydride, urea, zinc acetate, and magnesium acetate. The molar ratio of the initial substances is taken in the ratio of 1:4:3, and it has been synthesized with a yield of 89.5% and the reaction carried out at 225°C. The structure of this obtained pigment has been analyzed by IR spectral analysis. Based on magnesium and zinc phthalocyanine structures, it is found that the formation of phthalocyanine rings gives a peak in the region of 744.52-792.74 cm–1, while the phenyl rings give a peak in the region of 975.98 cm–1. Its thermal stability has been measured by thermogravimetric analysis, SEM (scanning electron microscope), EDS, and elemental analysis. According to the results of the analysis, it is confirmed that magnesium-zinc phthalocyanine has been synthesized by forming phthalocyanine rings. Page(s): 881-887 Mon, 01 Sep 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/66509 2025-09-01T00:00:00Z